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Role of ELP6 in tumour progression and impact on ERK1/2 signalling pathway inhibitors in skin cutaneous melanoma

  • Authors:
    • Ying Liu
    • Qinrong Wang
    • Qian Li
    • Peng Ren
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education and Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China, Department of Pharmacy, Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China, Department of Urology, The Second Affiliated Hospital of Guizhou Medical University, Kaili, Guizhou 556000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 250
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    Published online on: March 26, 2025
       https://doi.org/10.3892/ol.2025.14996
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Abstract

Elongator acetyltransferase complex subunit 6 (ELP6), a subunit of the elongator complex, can increase the migratory potential of melanoma cells in vitro. However, the clinical relevance of ELP6 in patients with melanoma remains unclear. The present study aimed to investigate the role of ELP6 expression in melanoma progression and association with patient survival rates. Transcriptomic data from patients with melanoma available in The Cancer Genome Atlas, Gene Expression Profiling Interactive Analysis and cBioPortal databases were analysed to evaluate the associations between ELP6 expression levels and patient survival. In vitro experiments were conducted using short hairpin RNAs to downregulate ELP6, with a focus on cell viability, cell cycle regulation and the ERK1/2 signalling pathway. ELP6 expression levels were significantly elevated in patients with melanoma and were associated with poor survival outcomes. Knockdown of ELP6 resulted in decreased expression levels of p42 MAPK, reduced cell viability, G1 phase cell cycle arrest and led to reduced responsiveness to the MEK1/2 inhibitor U0126. ELP6 promotes melanoma progression via the ERK1/2 signalling pathway. Therefore, assessing ELP6 expression may offer potential therapeutic strategies for patients with melanoma.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Wang Q, Li Q and Ren P: Role of ELP6 in tumour progression and impact on ERK1/2 signalling pathway inhibitors in skin cutaneous melanoma. Oncol Lett 29: 250, 2025.
APA
Liu, Y., Wang, Q., Li, Q., & Ren, P. (2025). Role of ELP6 in tumour progression and impact on ERK1/2 signalling pathway inhibitors in skin cutaneous melanoma. Oncology Letters, 29, 250. https://doi.org/10.3892/ol.2025.14996
MLA
Liu, Y., Wang, Q., Li, Q., Ren, P."Role of ELP6 in tumour progression and impact on ERK1/2 signalling pathway inhibitors in skin cutaneous melanoma". Oncology Letters 29.5 (2025): 250.
Chicago
Liu, Y., Wang, Q., Li, Q., Ren, P."Role of ELP6 in tumour progression and impact on ERK1/2 signalling pathway inhibitors in skin cutaneous melanoma". Oncology Letters 29, no. 5 (2025): 250. https://doi.org/10.3892/ol.2025.14996
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Wang Q, Li Q and Ren P: Role of ELP6 in tumour progression and impact on ERK1/2 signalling pathway inhibitors in skin cutaneous melanoma. Oncol Lett 29: 250, 2025.
APA
Liu, Y., Wang, Q., Li, Q., & Ren, P. (2025). Role of ELP6 in tumour progression and impact on ERK1/2 signalling pathway inhibitors in skin cutaneous melanoma. Oncology Letters, 29, 250. https://doi.org/10.3892/ol.2025.14996
MLA
Liu, Y., Wang, Q., Li, Q., Ren, P."Role of ELP6 in tumour progression and impact on ERK1/2 signalling pathway inhibitors in skin cutaneous melanoma". Oncology Letters 29.5 (2025): 250.
Chicago
Liu, Y., Wang, Q., Li, Q., Ren, P."Role of ELP6 in tumour progression and impact on ERK1/2 signalling pathway inhibitors in skin cutaneous melanoma". Oncology Letters 29, no. 5 (2025): 250. https://doi.org/10.3892/ol.2025.14996
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