Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
June-2025 Volume 29 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2025 Volume 29 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.xlsx
Article Open Access

Comprehensive analysis indicates DDX46 as a novel biomarker for the prognosis of lung adenocarcinoma

  • Authors:
    • Tingting Bian
    • Miaoseng Zheng
    • Ting Wang
    • Qing Zhang
    • Jianguo Zhang
    • Yifei Liu
    • Wenyu Shi
  • View Affiliations / Copyright

    Affiliations: Suzhou Medical College of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Pathology, The People's Hospital of Rugao, Rugao Hospital Affiliated to Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Radiation Oncology, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. China, Department of Pathology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China
    Copyright: © Bian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 292
    |
    Published online on: April 11, 2025
       https://doi.org/10.3892/ol.2025.15038
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The expression levels of DEAD‑box 46 (DDX46) are elevated in several malignancies; however, the function of DDX46 in lung adenocarcinoma (LUAD), including its expression patterns and functional implications, has not been fully elucidated. The present study primarily explores the potential role and underlying mechanism of DDX46 in the malignant progression of LUAD. The present study analyzed both publicly available databases and clinical specimens to assess DDX46 expression in LUAD and explore its prognostic significance. The findings demonstrated that elevated DDX46 expression was associated with a worse prognosis in patients with LUAD in comparison with a low DDX46 expression. Functional assays, including Cell Counting Kit‑8, colony formation, 5‑ethynyl‑2'‑deoxyuridine incorporation, flow cytometry, wound healing and Transwell assays, indicated that silencing DDX46 suppressed cancer cell migration, enhanced apoptosis, and induced G0/G1 phase cell cycle arrest. Moreover, DDX46 expression was correlated with the infiltration of T cells, natural killer cells and monocytes, as well as with several immune checkpoints and chemokines. Additionally, the results identified a marked association between DDX46 and the Wnt signaling pathway in LUAD. Low DDX46 expression was also demonstrated to be associated with increased drug responsiveness in patients. In conclusion, DDX46 holds promise as a dual‑purpose marker for the diagnosis and therapy of patients with LUAD.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Collisson EA, Campbell JD, Brooks AN, Berger AH, Lee W, Chmielecki J, Beer DG, Cope L, Creighton CJ, Danilova L, et al: Comprehensive molecular profiling of lung adenocarcinoma: The cancer genome atlas research network. Nature. 511:543–550. 2014. View Article : Google Scholar

2 

Chen P, Liu Y, Wen Y and Zhou C: Non-small cell lung cancer in China. Cancer Commun (Lond). 42:937–970. 2022. View Article : Google Scholar : PubMed/NCBI

3 

Zulfiqar B, Farooq A, Kanwal S and Asghar K: Immunotherapy and targeted therapy for lung cancer: Current status and future perspectives. Front Pharmacol. 13:10351712022. View Article : Google Scholar : PubMed/NCBI

4 

Herbst RS, Morgensztern D and Boshoff C: The biology and management of non-small cell lung cancer. Nature. 553:446–454. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Denisenko TV, Budkevich IN and Zhivotovsky B: Cell death-based treatment of lung adenocarcinoma. Cell Death Dis. 9:1172018. View Article : Google Scholar : PubMed/NCBI

6 

Hooper C and Hilliker A: Packing them up and dusting them off: RNA helicases and mRNA storage. Biochim Biophys Acta. 1829:824–834. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Linder P and Jankowsky E: From unwinding to clamping-the DEAD box RNA helicase family. Nat Rev Mol Cell Biol. 12:505–516. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Owttrim GW: RNA helicases: Diverse roles in prokaryotic response to abiotic stress. RNA Biol. 10:96–110. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Robert F and Pelletier J: Perturbations of RNA helicases in cancer. Wiley Interdiscip Rev RNA. 4:333–349. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Steimer L and Klostermeier D: RNA helicases in infection and disease. RNA Biol. 9:751–771. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Abdelhaleem M, Maltais L and Wain H: The human DDX and DHX gene families of putative RNA helicases. Genomics. 81:618–622. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M and Lührmann R: Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. EMBO J. 21:4978–4988. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Li B, Li YM, He WT, Chen H, Zhu HW, Liu T, Zhang JH, Song TN and Zhou YL: Knockdown of DDX46 inhibits proliferation and induces apoptosis in esophageal squamous cell carcinoma cells. Oncol Rep. 36:223–230. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Jiang F, Zhang D, Li G and Wang X: Knockdown of DDX46 inhibits the invasion and tumorigenesis in osteosarcoma cells. Oncol Res. 25:417–25. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Chen L, Xu M, Zhong W, Hu Y and Wang G: Knockdown of DDX46 suppresses the proliferation and invasion of gastric cancer through inactivating Akt/GSK-3β/β-catenin pathway. Exp Cell Res. 399:1124482021. View Article : Google Scholar : PubMed/NCBI

16 

Wang Z, Jensen MA and Zenklusen JC: A practical guide to the cancer genome atlas (TCGA). Methods Mol Biol. 1418:111–141. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Zheng M, Liu J, Bian T, Liu L, Sun H, Zhou H, Zhao C, Yang Z, Shi J and Liu Y: Correlation between prognostic indicator AHNAK2 and immune infiltrates in lung adenocarcinoma. Int Immunopharmacol. 90:1071342021. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Sun D, Wang J, Han Y, Dong X, Ge J, Zheng R, Shi X, Wang B, Li Z, Ren P, et al: TISCH: A comprehensive web resource enabling interactive single-cell transcriptome visualization of tumor microenvironment. Nucleic Acids Res. 49(D1): D1420–D1430. 2021. View Article : Google Scholar : PubMed/NCBI

20 

Lei Y, Zhou B, Meng X, Liang M, Song W, Liang Y, Gao Y and Wang M: A risk score model based on lipid metabolism-related genes could predict response to immunotherapy and prognosis of lung adenocarcinoma: A multi-dataset study and cytological validation. Discov Oncol. 14:1882023. View Article : Google Scholar : PubMed/NCBI

21 

Ru B, Wong CN, Tong Y, Zhong JY, Zhong SSW, Wu WC, Chu KC, Wong CY, Lau CY, Chen I, et al: TISIDB: An integrated repository portal for tumor-immune system interactions. Bioinformatics. 35:4200–4202. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Komuro H, Shinohara S, Fukushima Y, Demachi-Okamura A, Muraoka D, Masago K, Matsui T, Sugita Y, Takahashi Y, Nishida R, et al: Single-cell sequencing on CD8+ TILs revealed the nature of exhausted T cells recognizing neoantigen and cancer/testis antigen in non-small cell lung cancer. J Immunother Cancer. 11:e0071802023. View Article : Google Scholar : PubMed/NCBI

23 

Yang W, Soares J, Greninger P, Edelman EJ, Lightfoot H, Forbes S, Bindal N, Beare D, Smith JA, Thompson IR, et al: Genomics of drug sensitivity in cancer (GDSC): A resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Res. 41((Database Issue)): D955–D961. 2013.PubMed/NCBI

24 

Li M, Ma Y, Huang P, Du A, Yang X, Zhang S, Xing C, Liu F and Cao J: Lentiviral DDX46 knockdown inhibits growth and induces apoptosis in human colorectal cancer cells. Gene. 560:237–244. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Ma Z, Song J, Hua Y, Wang Y, Cao W, Wang H and Hou L: The role of DDX46 in breast cancer proliferation and invasiveness: A potential therapeutic target. Cell Biol Int. 47:283–291. 2023. View Article : Google Scholar : PubMed/NCBI

26 

Admoni-Elisha L, Nakdimon I, Shteinfer A, Prezma T, Arif T, Arbel N, Melkov A, Zelichov O, Levi I and Shoshan-Barmatz V: Novel biomarker proteins in chronic lymphocytic leukemia: Impact on diagnosis, prognosis and treatment. PLoS One. 11:e01485002016. View Article : Google Scholar : PubMed/NCBI

27 

Lin Q, Jin HJ, Zhang D and Gao L: DDX46 silencing inhibits cell proliferation by activating apoptosis and autophagy in cutaneous squamous cell carcinoma. Mol Med Rep. 22:4236–4242. 2020.PubMed/NCBI

28 

Zhang C, Kuang M, Li M, Feng L, Zhang K and Cheng S: SMC4, which is essentially involved in lung development, is associated with lung adenocarcinoma progression. Sci Rep. 6:345082016. View Article : Google Scholar : PubMed/NCBI

29 

Ma J, Gao Z and Liu X: DDX46 accelerates the proliferation of glioblastoma by activating the MAPK-p38 signaling. J BUON. 26:2084–2089. 2021.PubMed/NCBI

30 

You X, Cui H, Yu N and Li Q: Knockdown of DDX46 inhibits trophoblast cell proliferation and migration through the PI3K/Akt/mTOR signaling pathway in preeclampsia. Open Life Sci. 15:400–408. 2020. View Article : Google Scholar : PubMed/NCBI

31 

Disoma C, Zhou Y, Li S, Peng J and Xia Z: Wnt/β-catenin signaling in colorectal cancer: Is therapeutic targeting even possible? Biochimie. 195:39–53. 2022. View Article : Google Scholar : PubMed/NCBI

32 

Wan C, Mahara S, Sun C, Doan A, Chua HK, Xu D, Bian J, Li Y, Zhu D, Sooraj D, et al: Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signaling identifies therapeutic targets for colorectal cancer. Sci Adv. 7:eabf25672021. View Article : Google Scholar : PubMed/NCBI

33 

Zhan T, Rindtorff N and Boutros M: Wnt signaling in cancer. Oncogene. 36:1461–1473. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Hankey W, Frankel WL and Groden J: Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: Implications for therapeutic targeting. Cancer Metastasis Rev. 37:159–172. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Bai R, Yin P, Xing Z, Wu S, Zhang W, Ma X, Gan X, Liang Y, Zang Q, Lei H, et al: Investigation of GPR143 as a promising novel marker for the progression of skin cutaneous melanoma through bioinformatic analyses and cell experiments. Apoptosis. 29:372–392. 2024. View Article : Google Scholar : PubMed/NCBI

36 

Ino Y, Yamazaki-Itoh R, Shimada K, Iwasaki M, Kosuge T, Kanai Y and Hiraoka N: Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer. Br J Cancer. 108:914–923. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Schneider K, Marbaix E, Bouzin C, Hamoir M, Mahy P, Bol V and Gregoire V: Immune cell infiltration in head and neck squamous cell carcinoma and patient outcome: A retrospective study. Acta Oncol. 57:1165–1172. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Franciszkiewicz K, Boissonnas A, Boutet M, Combadiere C and Mami-Chouaib F: Role of chemokines and chemokine receptors in shaping the effector phase of the antitumor immune response. Cancer Res. 72:6325–6332. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Koizumi K, Hojo S, Akashi T, Yasumoto K and Saiki I: Chemokine receptors in cancer metastasis and cancer cell-derived chemokines in host immune response. Cancer Sci. 98:1652–1658. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Hirth A, Fatti E, Netz E, Acebron SP, Papageorgiou D, Švorinić A, Cruciat CM, Karaulanov E, Gopanenko A, Zhu T, et al: DEAD box RNA helicases are pervasive protein kinase interactors and activators. Genome Res. 34:952–966. 2024. View Article : Google Scholar : PubMed/NCBI

41 

Shariati M and Meric-Bernstam F: Targeting AKT for cancer therapy. Expert Opin Investig Drugs. 28:977–988. 2019. View Article : Google Scholar : PubMed/NCBI

42 

Wu SG and Shih JY: Management of acquired resistance to EGFR TKI-targeted therapy in advanced non-small cell lung cancer. Mol Cancer. 17:382018. View Article : Google Scholar : PubMed/NCBI

43 

Wu CH, Lin KH, Fu BS, Hsu FT, Tsai JJ, Weng MC and Pan PJ: Sorafenib induces apoptosis and inhibits NF-κB-mediated anti-apoptotic and metastatic potential in osteosarcoma cells. Anticancer Res. 41:1251–1259. 2021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Bian T, Zheng M, Wang T, Zhang Q, Zhang J, Liu Y and Shi W: Comprehensive analysis indicates DDX46 as a novel biomarker for the prognosis of lung adenocarcinoma. Oncol Lett 29: 292, 2025.
APA
Bian, T., Zheng, M., Wang, T., Zhang, Q., Zhang, J., Liu, Y., & Shi, W. (2025). Comprehensive analysis indicates DDX46 as a novel biomarker for the prognosis of lung adenocarcinoma. Oncology Letters, 29, 292. https://doi.org/10.3892/ol.2025.15038
MLA
Bian, T., Zheng, M., Wang, T., Zhang, Q., Zhang, J., Liu, Y., Shi, W."Comprehensive analysis indicates DDX46 as a novel biomarker for the prognosis of lung adenocarcinoma". Oncology Letters 29.6 (2025): 292.
Chicago
Bian, T., Zheng, M., Wang, T., Zhang, Q., Zhang, J., Liu, Y., Shi, W."Comprehensive analysis indicates DDX46 as a novel biomarker for the prognosis of lung adenocarcinoma". Oncology Letters 29, no. 6 (2025): 292. https://doi.org/10.3892/ol.2025.15038
Copy and paste a formatted citation
x
Spandidos Publications style
Bian T, Zheng M, Wang T, Zhang Q, Zhang J, Liu Y and Shi W: Comprehensive analysis indicates DDX46 as a novel biomarker for the prognosis of lung adenocarcinoma. Oncol Lett 29: 292, 2025.
APA
Bian, T., Zheng, M., Wang, T., Zhang, Q., Zhang, J., Liu, Y., & Shi, W. (2025). Comprehensive analysis indicates DDX46 as a novel biomarker for the prognosis of lung adenocarcinoma. Oncology Letters, 29, 292. https://doi.org/10.3892/ol.2025.15038
MLA
Bian, T., Zheng, M., Wang, T., Zhang, Q., Zhang, J., Liu, Y., Shi, W."Comprehensive analysis indicates DDX46 as a novel biomarker for the prognosis of lung adenocarcinoma". Oncology Letters 29.6 (2025): 292.
Chicago
Bian, T., Zheng, M., Wang, T., Zhang, Q., Zhang, J., Liu, Y., Shi, W."Comprehensive analysis indicates DDX46 as a novel biomarker for the prognosis of lung adenocarcinoma". Oncology Letters 29, no. 6 (2025): 292. https://doi.org/10.3892/ol.2025.15038
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team