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Case Report Open Access

Discussion on surgical approaches for giant, well‑differentiated liposarcomas of the esophagus: Report of two cases

  • Authors:
    • Jian Ma
    • Lihang Liao
    • Xiaojun Du
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China, Department of Thoracic Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 294
    |
    Published online on: April 11, 2025
       https://doi.org/10.3892/ol.2025.15040
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Abstract

Giant liposarcoma of the esophagus is an exceedingly rare esophageal tumor with complex treatment options. This study investigated the treatment modalities and reported on the clinical outcomes of two cases involving giant, well‑differentiated liposarcoma of the esophagus, providing a reference for the management of similar cases. Both tumors measured >20 cm in length and had diameters exceeding 4 cm; one case exhibited a lobulated appearance with visibly expanded blood vessels on its surface. Following discussions within a multidisciplinary team, under general anesthesia with tracheal intubation, the endoscopy team conducted endoscopic submucosal dissection, collaborating with the thoracic surgery team to manage potential bleeding risks. Both patients successfully underwent endoscopic tumor removal with postoperative pathology confirming the presence of well‑differentiated liposarcoma and no observed complications. For patients with giant and complex well‑differentiated liposarcomas, endoscopic dissection in conjunction with multidisciplinary collaboration represents a safe and effective treatment option, ensuring complete tumor removal while minimizing surgical trauma and enhancing patient prognosis.
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1 

Ducimetière F, Lurkin A, Ranchère-Vince D, Decouvelaere AV, Péoc'h M, Istier L, Chalabreysse P, Muller C, Alberti L, Bringuier PP, et al: Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing. PLoS One. 6:e202942011. View Article : Google Scholar : PubMed/NCBI

2 

Anderson WJ and Doyle LA: Updates from the 2020 world health organization classification of soft tissue and bone tumours. Histopathology. 78:644–657. 2021. View Article : Google Scholar : PubMed/NCBI

3 

Resag A, Toffanin G, Benešová I, Müller L, Potkrajcic V, Ozaniak A, Lischke R, Bartunkova J, Rosato A, Jöhrens K, et al: The immune contexture of liposarcoma and its clinical implications. Cancers (Basel). 14:45782022. View Article : Google Scholar : PubMed/NCBI

4 

Somaiah N and Tap W: MDM2-p53 in liposarcoma: The need for targeted therapies with novel mechanisms of action. Cancer Treat Rev. 122:1026682024. View Article : Google Scholar : PubMed/NCBI

5 

Thway K: Well-differentiated liposarcoma and dedifferentiated liposarcoma: An updated review. Semin Diagn Pathol. 36:112–121. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Ferrari D, Bernardi D, Siboni S, Lazzari V, Asti E and Bonavina L: Esophageal lipoma and liposarcoma: A systematic review. World J Surg. 45:225–234. 2021. View Article : Google Scholar : PubMed/NCBI

7 

Ng YA, Lee J, Zheng XJ, Nagaputra JC, Tan SH and Wong SA: Giant pedunculated oesophageal liposarcomas: A review of literature and resection techniques. Int J Surg Case Rep. 64:113–119. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Temes R, Quinn P, Davis M, Endara S, Follis F, Pett S and Wernly J: Endoscopic resection of esophageal liposarcoma. J Thorac Cardiovasc Surg. 116:365–367. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Goldblum JR, Folpe AL and Weiss SW: Enzinger and Weiss's soft tissue tumors. 7th ed. Elsevier; Philadelphia: 2020

10 

Lee ATJ, Thway K, Huang PH and Jones RL: Clinical and molecular spectrum of liposarcoma. J Clin Oncol. 36:151–159. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Valiuddin HM, Barbetta A, Mungo B, Montgomery EA and Molena D: Esophageal liposarcoma: Well-differentiated rhabdomyomatous type. World J Gastrointest Oncol. 8:835–839. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Lin ZC, Chang XZ, Huang XF, Zhang CL, Yu GS, Wu SY, Ye M and He JX: Giant liposarcoma of the esophagus: A case report. World J Gastroenterol. 21:9827–9832. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Graham RP, Yasir S, Fritchie KJ, Reid MD, Greipp PT and Folpe AL: Polypoid fibroadipose tumors of the esophagus: ‘Giant fibrovascular polyp’ or liposarcoma? A clinicopathological and molecular cytogenetic study of 13 cases. Mod Pathol. 31:337–342. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Caceres M, Steeb G, Wilks SM and Garrett HE Jr: Large pedunculated polyps originating in the esophagus and hypopharynx. Ann Thorac Surg. 81:393–396. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Kiełbowski K, Ruszel N, Skrzyniarz SA, Wojtyś ME, Becht R, Ptaszyński K, Gajić D and Wójcik J: Clinicopathological features of intrathoracic liposarcoma-A systematic review with an illustrative case. J Clin Med. 11:73532022. View Article : Google Scholar : PubMed/NCBI

16 

Chen C, He X, Jing WY, Qiu Y, Chen M, Luo TY, Liu XY, Chen HJ, Zhang HY and Bu H: Diagnostic value of MDM2 RNA in situ hybridization in atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma. Zhonghua Bing Li Xue Za Zhi. 51:190–195. 2022.PubMed/NCBI

17 

Takiguchi G, Nakamura T, Otowa Y, Tomono A, Kanaji S, Oshikiri T, Suzuki S, Ishida T and Kakeji Y: Successful resection of giant esophageal liposarcoma by endoscopic submucosal dissection combined with surgical retrieval: A case report and literature review. Surg Case Rep. 2:902016. View Article : Google Scholar : PubMed/NCBI

18 

Ye YW, Liao MY, Mou ZM, Shi XX and Xie YC: Thoracoscopic resection of a huge esophageal dedifferentiated liposarcoma: A case report. World J Clin Cases. 8:1698–1704. 2020. View Article : Google Scholar : PubMed/NCBI

19 

Bernardi D, Ferrari D, Siboni S, Porta M, Bruni B and Bonavina L: Minimally invasive approach to esophageal lipoma. J Surg Case Rep. 2020:rjaa1232020. View Article : Google Scholar : PubMed/NCBI

20 

Lee MJ, Lee MW, Joo DC, Hong SM, Baek DH, Lee BE, Kim GH and Song GA: Effective endoscopic submucosal dissection of a huge esophageal liposarcoma: A case report. Korean J Gastroenterol. 83:243–246. 2024. View Article : Google Scholar : PubMed/NCBI

21 

Ogami T, Bozanich N, Richter JE and Velanovich V: Giant esophageal liposarcoma. J Gastrointest Surg. 22:368–370. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Rodríguez Pérez A, Pérez Serrano N, García Tejero A, Escudero Nalda B and Gil Albarellos R: Giant esophageal liposarcoma in asymptomatic young patient. Cir Esp (Engl Ed). 96:381–383. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Fontes F, Fernandes D, Almeida A, Sá I and Dinis-Ribeiro M: Patient-reported outcomes after surgical, endoscopic, or radiological techniques for nutritional support in esophageal cancer patients: A systematic review. Curr Oncol. 31:6171–6190. 2024. View Article : Google Scholar : PubMed/NCBI

24 

Ajani JA, D'Amico TA, Bentrem DJ, Cooke D, Corvera C, Das P, Enzinger PC, Enzler T, Farjah F, Gerdes H, et al: Esophageal and esophagogastric junction cancers, Version 2.2023, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 21:393–422. 2023. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ma J, Liao L and Du X: Discussion on surgical approaches for giant, well‑differentiated liposarcomas of the esophagus: Report of two cases. Oncol Lett 29: 294, 2025.
APA
Ma, J., Liao, L., & Du, X. (2025). Discussion on surgical approaches for giant, well‑differentiated liposarcomas of the esophagus: Report of two cases. Oncology Letters, 29, 294. https://doi.org/10.3892/ol.2025.15040
MLA
Ma, J., Liao, L., Du, X."Discussion on surgical approaches for giant, well‑differentiated liposarcomas of the esophagus: Report of two cases". Oncology Letters 29.6 (2025): 294.
Chicago
Ma, J., Liao, L., Du, X."Discussion on surgical approaches for giant, well‑differentiated liposarcomas of the esophagus: Report of two cases". Oncology Letters 29, no. 6 (2025): 294. https://doi.org/10.3892/ol.2025.15040
Copy and paste a formatted citation
x
Spandidos Publications style
Ma J, Liao L and Du X: Discussion on surgical approaches for giant, well‑differentiated liposarcomas of the esophagus: Report of two cases. Oncol Lett 29: 294, 2025.
APA
Ma, J., Liao, L., & Du, X. (2025). Discussion on surgical approaches for giant, well‑differentiated liposarcomas of the esophagus: Report of two cases. Oncology Letters, 29, 294. https://doi.org/10.3892/ol.2025.15040
MLA
Ma, J., Liao, L., Du, X."Discussion on surgical approaches for giant, well‑differentiated liposarcomas of the esophagus: Report of two cases". Oncology Letters 29.6 (2025): 294.
Chicago
Ma, J., Liao, L., Du, X."Discussion on surgical approaches for giant, well‑differentiated liposarcomas of the esophagus: Report of two cases". Oncology Letters 29, no. 6 (2025): 294. https://doi.org/10.3892/ol.2025.15040
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