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Article Open Access

Differences in the role of Gper1 in colorectal cancer progression depending on sex

  • Authors:
    • Iveta Herichová
    • Richard Reis
    • Denisa Vanátová
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    Affiliations: Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University in Bratislava, 84215 Bratislava, Slovak Republic, First Surgery Department, University Hospital, Comenius University in Bratislava, 81107 Bratislava, Slovak Republic
    Copyright: © Herichová et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 305
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    Published online on: April 17, 2025
       https://doi.org/10.3892/ol.2025.15051
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Abstract

To evaluate the role of 17β‑oestradiol (E2) in the sex‑dependent progression of colorectal cancer (CRC), the present study focused on E2 signalling mediated via the nuclear receptors [oestrogen receptor (ESR)1 and ESR2] and the membrane G protein‑coupled oestrogen receptor 1 (Gper1) in males and females diagnosed with CRC. This study also investigated Gper1 signalling in the CRC cell lines DLD1 and LoVo, which differ in the p53 pathway. In cancer tissue, Gper1 becomes by far the most abundant E2 receptor due to an increase in Gper1 and a decrease in ESR2 expression. These changes are more prominent in males than in females. More pronounced differences in Gper1 expression between cancer and adjacent tissues were observed in males in lower stages compared with those in higher stages of disease and females. High expression of Gper1 was associated with worse survival in males without nodal involvement but not in females. The expression of E2 receptors in the CRC cell lines DLD1 and LoVo resembles that of human cancer tissue. Silencing of Gper1 (siGper1) caused an increase in the rate of metabolism in LoVo cells with wild‑type tp53. In DLD1 cells with the mutated form of tp53, siGper1 did not exert this effect. High levels of Gper1 were associated with worse survival and could contribute to sex‑dependent changes in the CRC prognosis. Tumour suppressor effects of Gper1 were, at least to some extent, dependent on signalling downstream of p53, which was more frequently deficient in males than in females. Overall, this suggests that up‑regulation of Gper1 (or administration of a Gper1 agonist) would be more beneficial for patients with wild‑type tp53.
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1 

Cardoso R, Guo F, Heisser T, Hackl M, Ihle P, De Schutter H, Van Damme N, Valerianova Z, Atanasov T, Májek O, et al: Colorectal cancer incidence, mortality, and stage distribution in European countries in the colorectal cancer screening era: An international population-based study. Lancet Oncol. 22:1002–1013. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD, Fuchs HE and Jemal A: Cancer statistics, 2021. CA Cancer J Clin. 71:7–33. 2021. View Article : Google Scholar : PubMed/NCBI

3 

Xi Y and Xu P: Global colorectal cancer burden in 2020 and projections to 2040. Transl Oncol. 14:1011742021. View Article : Google Scholar : PubMed/NCBI

4 

Murphy N, Ward HA, Jenab M, Rothwell JA, Boutron-Ruault MC, Carbonnel F, Kvaskoff M, Kaaks R, Kühn T, Boeing H, et al: Heterogeneity of colorectal cancer risk factors by anatomical subsite in 10 european countries: Amultinational cohort study. Clin Gastroenterol Hepatol. 17:1323–1331.e6. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Gausman V, Dornblaser D, Anand S, Hayes RB, O'Connell K, Du M and Liang PS: Risk factors associated with early-onset colorectal cancer. Clin Gastroenterol Hepatol. 18:2752–2759.e2. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Jacobs ET, Thompson PA and Martínez ME: Diet, gender, and colorectal neoplasia. J Clin Gastroenterol. 41:731–746. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Quirt JS, Nanji S, Wei X, Flemming JA and Booth CM: Is there a sex effect in colon cancer? Disease characteristics, management, and outcomes in routine clinical practice. Curr Oncol. 24:e15–e23. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Lopes-Ramos CM, Quackenbush J and DeMeo DL: Genome-wide sex and gender differences in cancer. Front Oncol. 10:5977882020. View Article : Google Scholar : PubMed/NCBI

9 

Høydahl Ø, Edna TH, Xanthoulis A, Lydersen S and Endreseth BH: Long-term trends in colorectal cancer: Incidence, localization, and presentation. BMC Cancer. 20:10772020. View Article : Google Scholar : PubMed/NCBI

10 

Johnson CM, Wei C, Ensor JE, Smolenski DJ, Amos CI, Levin B and Berry DA: Meta-analyses of colorectal cancer risk factors. Cancer Causes Control. 24:1207–1222. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Murphy N, Ward HA, Jenab M, Rothwell JA, Boutron-Ruault MC, Carbonnel F, Kvaskoff M, Kaaks R, Kühn T, Boeing H, et al: Heterogeneity of colorectal cancer risk factors by anatomical subsite in 10 European countries: A multinational cohort study. Clin Gastroenterol Hepatol. 17:1323–1331.e6. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Murphy N, Moreno V, Hughes DJ, Vodicka L, Vodicka P, Aglago EK, Gunter MJ and Jenab M: Lifestyle and dietary environmental factors in colorectal cancer susceptibility. Mol Aspects Med. 69:2–9. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Wele P, Wu X and Shi H: Sex-dependent differences in colorectal cancer: With a focus on obesity. Cells. 11:36882022. View Article : Google Scholar : PubMed/NCBI

14 

Barzi A, Lenz AM, Labonte MJ and Lenz HJ: Molecular pathways: Estrogen pathway in colorectal cancer. Clin Cancer Res. 19:5842–5848. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Nie X, Xie R and Tuo B: Effects of estrogen on the gastrointestinal tract. Dig Dis Sci. 63:583–596. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Labadie JD, Harrison TA, Banbury B, Amtay EL, Bernd S, Brenner H, Buchanan DD, Campbell PT, Cao Y, Chan AT, et al: Postmenopausal hormone therapy and colorectal cancer risk by molecularly defined subtypes and tumor location. JNCI Cancer Spectr. 4:pkaa0422020. View Article : Google Scholar : PubMed/NCBI

17 

Qiu YA, Xiong J and Yu T: Role of G Protein-coupled estrogen receptor in digestive system carcinomas: A minireview. Onco Targets Ther. 14:2611–2622. 2021. View Article : Google Scholar : PubMed/NCBI

18 

Prossnitz ER and Barton M: The G protein-coupled oestrogen receptor GPER in health and disease: An update. Nat Rev Endocrinol. 19:407–424. 2023. View Article : Google Scholar : PubMed/NCBI

19 

Heldring N, Pike A, Andersson S, Matthews J, Cheng G, Hartman J, Tujague M, Ström A, Treuter E, Warner M and Gustafsson JA: Estrogen receptors: How do they signal and what are their targets. Physiol Rev. 87:905–931. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Fuentes N and Silveyra P: Estrogen receptor signaling mechanisms. Adv Protein Chem Struct Biol. 116:135–170. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Otto C, Rohde-Schulz B, Schwarz G, Fuchs I, Klewer M, Brittain D, Langer G, Bader B, Prelle K, Nubbemeyer R and Fritzemeier KH: G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiol. Endocrinology. 149:4846–4856. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Ahmadian Elmi M, Motamed N and Picard D: Proteomic analyses of the G Protein-coupled estrogen receptor GPER1 reveal constitutive links to endoplasmic reticulum, glycosylation, trafficking, and calcium signaling. Cells. 12:25712023. View Article : Google Scholar : PubMed/NCBI

23 

Mauvais-Jarvis F, Lange CA and Levin ER: Membrane-initiated estrogen, androgen, and progesterone receptor signaling in health and disease. Endocr Rev. 43:720–742. 2022. View Article : Google Scholar : PubMed/NCBI

24 

Ding Q, Chorazyczewski J, Gros R, Motulsky HJ, Limbird LE and Feldman RD: Correlation of functional and radioligand binding characteristics of GPER ligands confirming aldosterone as a GPER agonist. Pharmacol Res Perspect. 10:e009952022. View Article : Google Scholar : PubMed/NCBI

25 

Leitman DC, Paruthiyil S, Vivar OI, Saunier EF, Herber CB, Cohen I, Tagliaferri M and Speed TP: Regulation of specific target genes and biological responses by estrogen receptor subtype agonists. Curr Opin Pharmacol. 10:629–636. 2010. View Article : Google Scholar : PubMed/NCBI

26 

De Francesco EM, Lappano R, Santolla MF, Marsico S, Caruso A and Maggiolini M: HIF-1α/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts (CAFs). Breast Cancer Res. 15:R642013. View Article : Google Scholar : PubMed/NCBI

27 

Rennert G, Rennert HS, Pinchev M, Lavie O and Gruber SB: Use of hormone replacement therapy and the risk of colorectal cancer. J Clin Oncol. 27:4542–4547. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Johnson JR, Lacey JV Jr, Lazovich D, Geller MA, Schairer C, Schatzkin A and Flood A: Menopausal hormone therapy and risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 18:196–203. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Symer MM, Wong NZ, Abelson JS, Milsom JW and Yeo HL: Hormone replacement therapy and colorectal cancer incidence and mortality in the prostate, lung, colorectal, and ovarian cancer screening trial. Clin Colorectal Cancer. 17:e281–e288. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Jang YC, Huang HL and Leung CY: Association of hormone replacement therapy with mortality in colorectal cancer survivor: A systematic review and meta-analysis. BMC Cancer. 19:11992019. View Article : Google Scholar : PubMed/NCBI

31 

Hang D, He X, Kværner AS, Chan AT, Wu K, Ogino S, Hu Z, Shen H, Giovannucci EL and Song M: Plasma sex hormones and risk of conventional and serrated precursors of colorectal cancer in postmenopausal women. BMC Med. 19:182021. View Article : Google Scholar : PubMed/NCBI

32 

Foster PA: Oestrogen and colorectal cancer: Mechanisms and controversies. Int J Colorectal Dis. 28:737–749. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Mori N, Keski-Rahkonen P, Gicquiau A, Rinaldi S, Dimou N, Harlid S, Harbs J, Van Guelpen B, Aune D, Cross AJ, et al: Endogenous circulating sex hormone concentrations and colon cancer risk in postmenopausal women: A prospective study and meta-analysis. JNCI Cancer Spectr. 5:pkab0842021. View Article : Google Scholar : PubMed/NCBI

34 

Das PK, Saha J, Pillai S, Lam AK, Gopalan V and Islam F: Implications of estrogen and its receptors in colorectal carcinoma. Cancer Med. 12:4367–4379. 2023. View Article : Google Scholar : PubMed/NCBI

35 

Mal R, Magner A, David J, Datta J, Vallabhaneni M, Kassem M, Manouchehri J, Willingham N, Stover D, Vandeusen J, et al: Estrogen receptor beta (ERβ): A ligand activated tumor suppressor. Front Oncol. 10:5873862020. View Article : Google Scholar : PubMed/NCBI

36 

Mahbub AA, Aslam A, Elzubier ME, El-Boshy M, Abdelghany AH, Ahmad J, Idris S, Almaimani R, Alsaegh A, El-Readi MZ, et al: Enhanced anti-cancer effects of oestrogen and progesterone co-therapy against colorectal cancer in males. Front Endocrinol (Lausanne). 13:9418342022. View Article : Google Scholar : PubMed/NCBI

37 

Refaat B, Aslam A, Idris S, Almalki AH, Alkhaldi MY, Asiri HA, Almaimani RA, Mujalli A, Minshawi F, Alamri SA, et al: Profiling estrogen, progesterone, and androgen receptors in colorectal cancer in relation to gender, menopausal status, clinical stage, and tumour sidedness. Front Endocrinol (Lausanne). 14:11872592023. View Article : Google Scholar : PubMed/NCBI

38 

Campbell-Thompson M, Lynch IJ and Bhardwaj B: Expression of estrogen receptor (ER) subtypes and ERbeta isoforms in colon cancer. Cancer Res. 61:632–640. 2001.PubMed/NCBI

39 

Maingi JW, Tang S, Liu S, Ngenya W and Bao E: Targeting estrogen receptors in colorectal cancer. Mol Biol Rep. 47:4087–4091. 2020. View Article : Google Scholar : PubMed/NCBI

40 

Herichová I, Jendrisková S, Pidíková P, Kršková L, Olexová L, Morová M, Stebelová K and Štefánik P: Effect of 17β-estradiol on the daily pattern of ACE2, ADAM17, TMPRSS2 and estradiol receptor transcription in the lungs and colon of male rats. PLoS One. 17:e02706092022. View Article : Google Scholar : PubMed/NCBI

41 

Weyant MJ, Carothers AM, Mahmoud NN, Bradlow HL, Remotti H, Bilinski RT and Bertagnolli MM: Reciprocal expression of ERalpha and ERbeta is associated with estrogen-mediated modulation of intestinal tumorigenesis. Cancer Res. 61:2547–2551. 2001.PubMed/NCBI

42 

Giroux V, Lemay F, Bernatchez G, Robitaille Y and Carrier JC: Estrogen receptor beta deficiency enhances small intestinal tumorigenesis in ApcMin/+ mice. Int J Cancer. 123:303–311. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Weige CC, Allred KF and Allred CD: Estradiol alters cell growth in nonmalignant colonocytes and reduces the formation of preneoplastic lesions in the colon. Cancer Res. 69:9118–9124. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Song CH, Kim N, Lee SM, Nam RH, Choi SI, Kang SR, Shin E, Lee DH, Lee HN and Surh YJ: Effects of 17β-estradiol on colorectal cancer development after azoxymethane/dextran sulfate sodium treatment of ovariectomized mice. Biochem Pharmacol. 164:139–151. 2019. View Article : Google Scholar : PubMed/NCBI

45 

Son HJ, Sohn SH, Kim N, Lee HN, Lee SM, Nam RH, Park JH, Song CH, Shin E, Na HY, et al: Effect of estradiol in an Azoxymethane/Dextran sulfate Sodium-treated mouse model of colorectal cancer: Implication for sex difference in colorectal cancer development. Cancer Res Treat. 51:632–648. 2019. View Article : Google Scholar : PubMed/NCBI

46 

Hartman J, Edvardsson K, Lindberg K, Zhao C, Williams C, Ström A and Gustafsson JA: Tumor repressive functions of estrogen receptor beta in SW480 colon cancer cells. Cancer Res. 69:6100–6106. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, et al: Proteomics. Tissue-based map of the human proteome. Science. 347:12604192015. View Article : Google Scholar : PubMed/NCBI

48 

Abancens M, Harvey BJ and McBryan J: GPER agonist G1 prevents Wnt-induced JUN upregulation in HT29 colorectal cancer cells. Int J Mol Sci. 23:125812022. View Article : Google Scholar : PubMed/NCBI

49 

Muller C, Chaney MF, Cohen JV, Garyantes T, Lin JJ, LoRusso P, Mita AC, Mita MM, Natale C, Orloff MM, et al: Phase 1b study of the novel first-in-class G protein-coupled estrogen receptor (GPER) agonist, LNS8801, in combination with pembrolizumab in patients with immune checkpoint inhibitor (ICI)-relapsed and refractory solid malignancies and dose escalation update. J Clinical Oncol. 40 (16_suppl):S2574. 2022. View Article : Google Scholar

50 

Hall KA and Filardo EJ: The G Protein-coupled estrogen receptor (GPER): A critical therapeutic target for cancer. Cells. 12:24602023. View Article : Google Scholar : PubMed/NCBI

51 

Liu Q, Chen Z, Jiang G, Zhou Y, Yang X, Huang H, Liu H, Du J and Wang H: Epigenetic down regulation of G protein-coupled estrogen receptor (GPER) functions as a tumor suppressor in colorectal cancer. Mol Cancer. 16:872017. View Article : Google Scholar : PubMed/NCBI

52 

Bühler M, Fahrländer J, Sauter A, Becker M, Wistorf E, Steinfath M and Stolz A: GPER1 links estrogens to centrosome amplification and chromosomal instability in human colon cells. Life Sci Alliance. 6:e2022014992022. View Article : Google Scholar : PubMed/NCBI

53 

Bustos V, Nolan ÁM, Nijhuis A, Harvey H, Parker A, Poulsom R, McBryan J, Thomas W, Silver A and Harvey BJ: GPER mediates differential effects of estrogen on colon cancer cell proliferation and migration under normoxic and hypoxic conditions. Oncotarget. 8:84258–84275. 2017. View Article : Google Scholar : PubMed/NCBI

54 

Santolla MF, Lappano R, De Marco P, Pupo M, Vivacqua A, Sisci D, Abonante S, Iacopetta D, Cappello AR, Dolce V, et al: G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17β-estradiol in cancer cells and cancer-associated fibroblasts. J Biol Chem. 287:43234–43245. 2012. View Article : Google Scholar : PubMed/NCBI

55 

Xie M, Liang JL, Huang HD, Wang MJ, Zhang T and Yang XF: Low doses of nonylphenol promote growth of colon cancer cells through activation of ERK1/2 via G Protein-coupled receptor 30. Cancer Res Treat. 51:1620–1631. 2019. View Article : Google Scholar : PubMed/NCBI

56 

Gilligan LC, Rahman HP, Hewitt AM, Sitch AJ, Gondal A, Arvaniti A, Taylor AE, Read ML, Morton DG and Foster PA: Estrogen activation by steroid sulfatase increases colorectal cancer proliferation via GPER. J Clin Endocrinol Metab. 102:4435–4447. 2017. View Article : Google Scholar : PubMed/NCBI

57 

Rouhimoghadam M, Lu AS, Salem AK and Filardo EJ: Therapeutic perspectives on the modulation of G-protein coupled estrogen receptor, GPER, Function. Front Endocrinol (Lausanne). 11:5912172020. View Article : Google Scholar : PubMed/NCBI

58 

Rodon J, Chaney M, Cohen J, Garyantes TK, Ishizuka J, Lin JJ, Lorusso P, Mita A, Mita M, Muller C, et al: The effect of LNS8801 in combination with pembrolizumab in patients with treatment-refractory cutaneous melanoma. J Immuno Ther Cancer. 11 (Suppl 1):A6272023.

59 

Shoushtari AN, Chaney MF, Cohen JV, Garyantes T, Lin JJ, Ishizuka JJ, Mita AC, Mita MM, Muller C, Natale C, et al: The effect of LNS8801 alone and in combination with pembrolizumab in patients with metastatic uveal melanoma. J Clin Oncol. 41 (16_Suppl):S9543. 2023. View Article : Google Scholar

60 

Holm A, Grände PO, Ludueña RF, Olde B, Prasad V, Leeb-Lundberg LM and Nilsson BO: The G protein-coupled oestrogen receptor 1 agonist G-1 disrupts endothelial cell microtubule structure in a receptor-independent manner. Mol Cell Biochem. 366:239–249. 2012. View Article : Google Scholar : PubMed/NCBI

61 

Wang C, Lv X, Jiang C and Davis JS: The putative G-protein coupled estrogen receptor agonist G-1 suppresses proliferation of ovarian and breast cancer cells in a GPER-independent manner. Am J Transl Res. 4:390–402. 2012.PubMed/NCBI

62 

Gui Y, Shi Z, Wang Z, Li JJ, Xu C, Tian R, Song X, Walsh MP, Li D, Gao J, et al: The GPER agonist G-1 induces mitotic arrest and apoptosis in human vascular smooth muscle cells independent of GPER. J Cell Physiol. 230:885–895. 2015. View Article : Google Scholar : PubMed/NCBI

63 

Mori T, Ito F, Matsushima H, Takaoka O, Tanaka Y, Koshiba A, Kusuki I and Kitawaki J: G protein-coupled estrogen receptor 1 agonist G-1 induces cell cycle arrest in the mitotic phase, leading to apoptosis in endometriosis. Fertil Steril. 103:1228–1235.e1. 2015. View Article : Google Scholar : PubMed/NCBI

64 

Lv X, He C, Huang C, Hua G, Wang Z, Remmenga SW, Rodabough KJ, Karpf AR, Dong J, Davis JS, et al: G-1 Inhibits breast cancer cell growth via targeting Colchicine-binding site of tubulin to interfere with microtubule assembly. Mol Cancer Ther. 16:1080–1091. 2017. View Article : Google Scholar : PubMed/NCBI

65 

Torres-López L, Olivas-Aguirre M, Villatoro-Gómez K and Dobrovinskaya O: The G-protein-coupled estrogen receptor agonist G-1 inhibits proliferation and causes apoptosis in leukemia cell lines of T lineage. Front Cell Dev Biol. 10:8114792022. View Article : Google Scholar : PubMed/NCBI

66 

Haupt S, Caramia F, Herschtal A, Soussi T, Lozano G, Chen H, Liang H, Speed TP and Haupt Y: Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network. Nat Commun. 10:53852019. View Article : Google Scholar : PubMed/NCBI

67 

Liu Y and Bodmer WF: Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines. Proc Natl Acad Sci USA. 103:976–981. 2006. View Article : Google Scholar : PubMed/NCBI

68 

Schneider CA, Rasband WS and Eliceiri KW: NIH Image to ImageJ: 25 years of image analysis. Nat Methods. 9:671–675. 2012. View Article : Google Scholar : PubMed/NCBI

69 

Recchia AG, De Francesco EM, Vivacqua A, Sisci D, Panno ML, Andò S and Maggiolini M: The G protein-coupled receptor 30 is up-regulated by hypoxia-inducible factor-1alpha (HIF-1alpha) in breast cancer cells and cardiomyocytes. J Biol Chem. 286:10773–10782. 2011. View Article : Google Scholar : PubMed/NCBI

70 

Jacenik D, Beswick EJ, Krajewska WM and Prossnitz ER: G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis. World J Gastroenterol. 25:4092–4104. 2019. View Article : Google Scholar : PubMed/NCBI

71 

Foley EF, Jazaeri AA, Shupnik MA, Jazaeri O and Rice LW: Selective loss of estrogen receptor beta in malignant human colon. Cancer Res. 60:245–248. 2000.PubMed/NCBI

72 

Jassam N, Bell SM, Speirs V and Quirke P: Loss of expression of oestrogen receptor beta in colon cancer and its association with Dukes' staging. Oncol Rep. 14:17–21. 2005.PubMed/NCBI

73 

Mostafaie N, Kállay E, Sauerzapf E, Bonner E, Kriwanek S, Cross HS, Huber KR and Krugluger W: Correlated downregulation of estrogen receptor beta and the circadian clock gene Per1 in human colorectal cancer. Mol Carcinog. 48:642–647. 2009. View Article : Google Scholar : PubMed/NCBI

74 

Herichova I, Reis R, Hasakova K, Vician M and Zeman M: Sex-dependent regulation of estrogen receptor beta in human colorectal cancer tissue and its relationship with clock genes and VEGF-A expression. Physiol Res. 68 (Suppl 3):S297–S305. 2019. View Article : Google Scholar : PubMed/NCBI

75 

Hasakova K, Vician M, Reis R, Zeman M and Herichova I: Sex-dependent correlation between survival and expression of genes related to the circadian oscillator in patients with colorectal cancer. Chronobiol Int. 35:1423–1434. 2018. View Article : Google Scholar : PubMed/NCBI

76 

Williams C, DiLeo A, Niv Y and Gustafsson JÅ: Estrogen receptor beta as target for colorectal cancer prevention. Cancer Lett. 372:48–56. 2016. View Article : Google Scholar : PubMed/NCBI

77 

Ya G, Wang H, Ma Y, Hu A, Ma Y, Hu J and Yu Y: Serum miR-129 functions as a biomarker for colorectal cancer by targeting estrogen receptor (ER) β. Pharmazie. 72:107–112. 2017.PubMed/NCBI

78 

Issa JP, Ottaviano YL, Celano P, Hamilton SR, Davidson NE and Baylin SB: Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet. 7:536–540. 1994. View Article : Google Scholar : PubMed/NCBI

79 

Jiang H, Teng R, Wang Q, Zhang X, Wang H, Wang Z, Cao J and Teng L: Transcriptional analysis of estrogen receptor alpha variant mRNAs in colorectal cancers and their matched normal colorectal tissues. J Steroid Biochem Mol Biol. 112:20–24. 2008. View Article : Google Scholar : PubMed/NCBI

80 

Topi G, Ghatak S, Satapathy SR, Ehrnström R, Lydrup ML and Sjölander A: Combined estrogen alpha and beta receptor expression has a prognostic significance for colorectal cancer patients. Front Med (Lausanne). 9:7396202022. View Article : Google Scholar : PubMed/NCBI

81 

Kennelly R, Kavanagh DO, Hogan AM and Winter DC: Oestrogen and the colon: Potential mechanisms for cancer prevention. Lancet Oncol. 94:385–391. 2008. View Article : Google Scholar : PubMed/NCBI

82 

Barton M, Filardo EJ, Lolait SJ, Thomas P, Maggiolini M and Prossnitz ER: Twenty years of the G protein-coupled estrogen receptor GPER: Historical and personal perspectives. J Steroid Biochem Mol Biol. 176:4–15. 2018. View Article : Google Scholar : PubMed/NCBI

83 

Harvey BJ and Harvey HM: Sex differences in colon cancer: Genomic and nongenomic signalling of oestrogen. Genes (Basel). 14:22252023. View Article : Google Scholar : PubMed/NCBI

84 

Nüssler NC, Reinbacher K, Shanny N, Schirmeier A, Glanemann M, Neuhaus P, Nussler AK and Kirschner M: Sex-specific differences in the expression levels of estrogen receptor subtypes in colorectal cancer. Gend Med. 5:209–217. 2008. View Article : Google Scholar : PubMed/NCBI

85 

Deli T, Orosz M and Jakab A: Hormone replacement therapy in cancer survivors-review of the literature. Pathol Oncol Res. 26:63–78. 2020. View Article : Google Scholar : PubMed/NCBI

86 

Topi G, Satapathy SR, Dash P, Fred Mehrabi S, Ehrnström R, Olsson R, Lydrup ML and Sjölander A: Tumour-suppressive effect of oestrogen receptor β in colorectal cancer patients, colon cancer cells, and a zebrafish model. J Pathol. 251:297–309. 2020. View Article : Google Scholar : PubMed/NCBI

87 

Tirado-Garibay AC, Falcón-Ruiz EA, Ochoa-Zarzosa A and López-Meza JE: GPER: An estrogen receptor key in metastasis and tumoral microenvironments. Int J Mol Sc. 24:149932023. View Article : Google Scholar : PubMed/NCBI

88 

Ambrosini G, Natale CA, Musi E, Garyantes T and Schwartz GK: The GPER agonist LNS8801 induces mitotic arrest and apoptosis in uveal melanoma cells. Cancer Res Commun. 3:540–547. 2023. View Article : Google Scholar : PubMed/NCBI

89 

Filardo EJ, Quinn JA, Bland KI and Frackelton AR Jr: Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. Mol Endocrinol. 14:1649–1660. 2000. View Article : Google Scholar : PubMed/NCBI

90 

Hsu LH, Chu NM, Lin YF and Kao SH: G-Protein coupled estrogen receptor in breast cancer. Int J Mol Sci. 20:3062019. View Article : Google Scholar : PubMed/NCBI

91 

Rubin Grandis J, Melhem MF, Gooding WE, Day R, Holst VA, Wagener MM, Drenning SD and Tweardy DJ: Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival. J Natl Cancer Inst. 90:824–832. 1998. View Article : Google Scholar : PubMed/NCBI

92 

Uribe ML, Marrocco I and Yarden Y: EGFR in cancer: Signaling mechanisms, drugs, and acquired resistance. Cancers (Basel). 13:27482021. View Article : Google Scholar : PubMed/NCBI

93 

Janani B, Vijayakumar M, Priya K, Kim JH, Prabakaran DS, Shahid M, Al-Ghamdi S, Alsaidan M, Othman Bahakim N, Hassan Abdelzaher M and Ramesh T: EGFR-based targeted therapy for colorectal cancer-promises and challenges. Vaccines (Basel). 10:4992022. View Article : Google Scholar : PubMed/NCBI

94 

Giannopoulou E, Antonacopoulou A, Floratou K, Papavassiliou AG and Kalofonos HP: Dual targeting of EGFR and HER-2 in colon cancer cell lines. Cancer Chemother Pharmacol. 63:973–981. 2009. View Article : Google Scholar : PubMed/NCBI

95 

Yuan HH, Han Y, Bian WX, Liu L and Bai YX: The effect of monoclonal antibody cetuximab (C225) in combination with tyrosine kinase inhibitor gefitinib (ZD1839) on colon cancer cell lines. Pathology. 44:547–551. 2012. View Article : Google Scholar : PubMed/NCBI

96 

Palumbo I, Piattoni S, Valentini V, Marini V, Contavalli P, Calzuola M, Vecchio FM, Cecchini D, Falzetti F and Aristei C: Gefitinib enhances the effects of combined radiotherapy and 5-fluorouracil in a colorectal cancer cell line. Int J Colorectal Dis. 29:31–41. 2014. View Article : Google Scholar : PubMed/NCBI

97 

Chen X, Liu Y, Yang HW, Zhou S, Cheng C, Zheng MW, Zhong L, Fu XY, Pan YL, Ma S, et al: SKLB-287, a novel oral multikinase inhibitor of EGFR and VEGFR2, exhibits potent antitumor activity in LoVo colorectal tumor model. Neoplasma. 61:514–22. 2014. View Article : Google Scholar : PubMed/NCBI

98 

Chuang SC, Chen CH, Chou YS, Ho ML and Chang JK: G Protein-coupled estrogen receptor mediates cell proliferation through the cAMP/PKA/CREB pathway in murine bone marrow mesenchymal stem cells. Int J Mol Sci. 21:64902020. View Article : Google Scholar : PubMed/NCBI

99 

Berg KCG, Eide PW, Eilertsen IA, Johannessen B, Bruun J, Danielsen SA, Bjørnslett M, Meza-Zepeda LA, Eknæs M, Lind GE, et al: Multi-omics of 34 colorectal cancer cell lines-a resource for biomedical studies. Mol Cancer. 16:1162017. View Article : Google Scholar : PubMed/NCBI

100 

Moulder DE, Hatoum D, Tay E, Lin Y and McGowan EM: The roles of p53 in mitochondrial dynamics and cancer metabolism: The pendulum between survival and death in breast cancer? Cancers (Basel). 10:1892018. View Article : Google Scholar : PubMed/NCBI

101 

Engeland K: Cell cycle regulation: P53-p21-RB signaling. Cell Death Differ. 29:946–960. 2022. View Article : Google Scholar : PubMed/NCBI

102 

Weißenborn C, Ignatov T, Ochel HJ, Costa SD, Zenclussen AC, Ignatova Z and Ignatov A: GPER functions as a tumor suppressor in triple-negative breast cancer cells. J Cancer Res Clin Oncol. 140:713–23. 2014. View Article : Google Scholar : PubMed/NCBI

103 

Rochette PJ, Bastien N, Lavoie J, Guérin SL and Drouin R: SW480, a p53 double-mutant cell line retains proficiency for some p53 functions. J Mol Biol. 352:44–57. 2005. View Article : Google Scholar : PubMed/NCBI

104 

Berglind H, Pawitan Y, Kato S, Ishioka C and Soussi T: Analysis of p53 mutation status in human cancer cell lines: A paradigm for cell line cross-contamination. Cancer Biol Ther. 7:699–708. 2008. View Article : Google Scholar : PubMed/NCBI

105 

Hassin O, Nataraj NB, Shreberk-Shaked M, Aylon Y, Yaeger R, Fontemaggi G, Mukherjee S, Maddalena M, Avioz A, Iancu O, et al: Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients. Nat Commun. 13:28002022. View Article : Google Scholar : PubMed/NCBI

106 

Leroy B, Girard L, Hollestelle A, Minna JD, Gazdar AF and Soussi T: Analysis of TP53 mutation status in human cancer cell lines: A reassessment. Hum Mutat. 35:756–765. 2014. View Article : Google Scholar : PubMed/NCBI

107 

Berger C, Qian Y and Chen X: The p53-estrogen receptor loop in cancer. Curr Mol Med. 13:1229–1240. 2013. View Article : Google Scholar : PubMed/NCBI

108 

Chen YC, Young MJ, Chang HP, Liu CY, Lee CC, Tseng YL, Wang YC, Chang WC and Hung JJ: Estradiol-mediated inhibition of DNMT1 decreases p53 expression to induce M2-macrophage polarization in lung cancer progression. Oncogenesis. 11:252022. View Article : Google Scholar : PubMed/NCBI

109 

Weige CC, Allred KF, Armstrong CM and Allred CD: P53 mediates estradiol induced activation of apoptosis and DNA repair in non-malignant colonocytes. J Steroid Biochem Mol Biol. 128:113–120. 2012. View Article : Google Scholar : PubMed/NCBI

110 

Qin C, Nguyen T, Stewart J, Samudio I, Burghardt R and Safe S: Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor kappaB/CCAAT-binding transcription factor-1 complex. Mol Endocrinol. 16:1793–809. 2022. View Article : Google Scholar : PubMed/NCBI

111 

Berger CE, Qian Y, Liu G, Chen H and Chen X: p53, a target of estrogen receptor (ER) α, modulates DNA damage-induced growth suppression in ER-positive breast cancer cells. J Biol Chem. 287:30117–30127. 2012. View Article : Google Scholar : PubMed/NCBI

112 

Swetzig WM, Wang J and Das GM: Estrogen receptor alpha (ERα/ESR1) mediates the p53-independent overexpression of MDM4/MDMX and MDM2 in human breast cancer. Oncotarget. 7:16049–16069. 2016. View Article : Google Scholar : PubMed/NCBI

113 

Mancini F, Giorgini L, Teveroni E, Pontecorvi A and Moretti F: Role of sex in the therapeutic targeting of p53 circuitry. Front Oncol. 11:6989462021. View Article : Google Scholar : PubMed/NCBI

114 

Konduri SD, Medisetty R, Liu W, Kaipparettu BA, Srivastava P, Brauch H, Fritz P, Swetzig WM, Gardner AE, Khan SA, et al: Mechanisms of estrogen receptor antagonism toward p53 and its implications in breast cancer therapeutic response and stem cell regulation. Proc Natl Acad Sci USA. 107:15081–6. 2010. View Article : Google Scholar : PubMed/NCBI

115 

Lu W and Katzenellenbogen BS: Estrogen receptor-β modulation of the ERα-p53 loop regulating gene expression, proliferation, and apoptosis in breast cancer. Horm Cancer. 8:230–242. 2017. View Article : Google Scholar : PubMed/NCBI

116 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI

117 

Bilancio A, Bontempo P, Di Donato M, Conte M, Giovannelli P, Altucci L, Migliaccio A and Castoria G: Bisphenol A induces cell cycle arrest in primary and prostate cancer cells through EGFR/ERK/p53 signaling pathway activation. Oncotarget. 8:115620–115631. 2017. View Article : Google Scholar : PubMed/NCBI

118 

Wei W, Chen ZJ, Zhang KS, Yang XL, Wu YM, Chen XH, Huang HB, Liu HL, Cai SH, Du J, et al: The activation of G protein-coupled receptor 30 (GPR30) inhibits proliferation of estrogen receptor-negative breast cancer cells in vitro and in vivo. Cell Death Dis. 5:e14282014. View Article : Google Scholar : PubMed/NCBI

119 

Morelli E, Hunter ZR, Fulciniti M, Gullà A, Perrotta ID, Zuccalà V, Federico C, Juli G, Manzoni M, Ronchetti D, et al: Therapeutic activation of G protein-coupled estrogen receptor 1 in Waldenström Macroglobulinemia. Exp Hematol Onco. 11:542022. View Article : Google Scholar

120 

Giebler HA, Lemasson I and Nyborg JK: p53 recruitment of CREB binding protein mediated through phosphorylated CREB: A novel pathway of tumor suppressor regulation. Mol Cell Biol. 20:4849–4858. 2000. View Article : Google Scholar : PubMed/NCBI

121 

Okoshi R, Ando K, Suenaga Y, Sang M, Kubo N, Kizaki H, Nakagawara A and Ozaki T: Transcriptional regulation of tumor suppressor p53 by cAMP-responsive element-binding protein/AMP-activated protein kinase complex in response to glucose deprivation. Genes Cells. 14:1429–1440. 2009. View Article : Google Scholar : PubMed/NCBI

122 

Lee CW, Ferreon JC, Ferreon AC, Arai M and Wright PE: Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation. Proc Natl Acad Sci USA. 107:19290–19295. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Herichová I, Reis R and Vanátová D: Differences in the role of Gper1 in colorectal cancer progression depending on sex. Oncol Lett 29: 305, 2025.
APA
Herichová, I., Reis, R., & Vanátová, D. (2025). Differences in the role of Gper1 in colorectal cancer progression depending on sex. Oncology Letters, 29, 305. https://doi.org/10.3892/ol.2025.15051
MLA
Herichová, I., Reis, R., Vanátová, D."Differences in the role of Gper1 in colorectal cancer progression depending on sex". Oncology Letters 29.6 (2025): 305.
Chicago
Herichová, I., Reis, R., Vanátová, D."Differences in the role of Gper1 in colorectal cancer progression depending on sex". Oncology Letters 29, no. 6 (2025): 305. https://doi.org/10.3892/ol.2025.15051
Copy and paste a formatted citation
x
Spandidos Publications style
Herichová I, Reis R and Vanátová D: Differences in the role of Gper1 in colorectal cancer progression depending on sex. Oncol Lett 29: 305, 2025.
APA
Herichová, I., Reis, R., & Vanátová, D. (2025). Differences in the role of Gper1 in colorectal cancer progression depending on sex. Oncology Letters, 29, 305. https://doi.org/10.3892/ol.2025.15051
MLA
Herichová, I., Reis, R., Vanátová, D."Differences in the role of Gper1 in colorectal cancer progression depending on sex". Oncology Letters 29.6 (2025): 305.
Chicago
Herichová, I., Reis, R., Vanátová, D."Differences in the role of Gper1 in colorectal cancer progression depending on sex". Oncology Letters 29, no. 6 (2025): 305. https://doi.org/10.3892/ol.2025.15051
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