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Intermediate‑risk factors affecting oncological outcome in patients with FIGO 2018 stage IB2 cervical cancer who do not receive adjuvant therapy

  • Authors:
    • Abdurrahman Alp Tokalioglu
    • Okan Oktar
    • Okan Aytekin
    • Aysun Alci
    • Alper Kahraman
    • Volkan Ege
    • Fatih Kilic
    • Burak Ersak
    • Fatih Celik
    • Hande Esra Koca Yildirim
    • Caner Cakir
    • Dilek Yuksel
    • Cigdem Kilic
    • Ilker Selcuk
    • Gunsu Kimyon Comert
    • Nurettin Boran
    • Derman Basaran
    • Isin Ureyen
    • Tayfun Toptas
    • Vakkas Korkmaz
    • Alper Karalok
    • Tolga Tasci
    • Ozlem Moraloglu Tekin
    • Yaprak Ustun
    • Nejat Ozgul
    • Taner Turan
  • View Affiliations / Copyright

    Affiliations: Department of Gynaecological Oncology, Ankara Bilkent City Hospital, Faculty of Medicine, University of Health Sciences, 06800 Ankara, Turkey, Department of Gynaecological Oncology, Ankara Etlik City Hospital, Faculty of Medicine, University of Health Sciences, 06170 Ankara, Turkey, Department of Gynaecological Oncology, Antalya Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Antalya 07100, Turkey, Department of Gynaecological Oncology, Faculty of Medicine, Hacettepe University, Ankara 06230, Turkey, Department of Gynaecological Oncology, Etlik Zubeyde Hanim Women's Health Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Ankara 06010, Turkey, Department of Gynaecological Oncology, Faculty of Medicine, Istinye University, 34010 Istanbul, Turkey, Department of Gynaecological Oncology, Faculty of Medicine, Bahcesehir University, 34349 Istanbul, Turkey, Department of Obstetrics and Gynaecology, Ankara Bilkent City Hospital, Faculty of Medicine, University of Health Sciences, Ankara 06800, Turkey, Department of Obstetrics and Gynaecology, Etlik Zubeyde Hanim Women's Health Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Ankara 06010, Turkey
    Copyright: © Tokalioglu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 308
    |
    Published online on: April 23, 2025
       https://doi.org/10.3892/ol.2025.15054
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Abstract

The objective of the present study was to examine how intermediate‑risk factors affect the oncological outcomes of patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) 2018 stage IB2 cervical cancer who do not undergo any adjuvant treatment. A multicentric retrospective study that involved 612 patients who were diagnosed with stage IA‑IB2 cervical cancer at seven tertiary gynaecological oncology centres between 1993 and 2023 was conducted. A total of 232 patients were classified as FIGO 2018 stage IB2. Patients who had received neoadjuvant chemotherapy, parametrial or surgical border involvement, received adjuvant therapy and synchronous tumours were excluded from the present cohort. Therefore, the present study cohort consisted of 120 patients who had undergone radical hysterectomy and lymphadenectomy. Among the 120 patients, 89 (74.2%) had squamous cell cancer, 18 (15%) had adenocarcinoma, 2 (1.7%) had a mixed type tumour consisting of squamous cell cancer and adenocarcinoma and 11 (9.1%) had other types of tumours (adenosquamous cancer and glassy cell cancer). Deep cervical stromal invasion was found in 68 (56.7%) patients. The duration of patient follow‑up varied from 1 to 246 months, with a median of 36 months. Overall, 6 patients (5%) experienced recurrence and 1 patient (0.8%) succumbed to the disease. The 3‑year disease‑free survival (DFS) rate was 94%, whereas the 3‑year overall survival rate was 99%. The presence of deep cervical stromal invasion had a statistically significant impact on DFS (P=0.038). Deep cervical stromal invasion was found to be associated with recurrence in patients with stage IB2 cervical cancer. Hence, the present study demonstrated that the presence of deep cervical stromal invasion may be considered a key parameter in determining whether adjuvant treatment should be applied in patients with stage IB2 cervical cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Tokalioglu A, Oktar O, Aytekin O, Alci A, Kahraman A, Ege V, Kilic F, Ersak B, Celik F, Koca Yildirim H, Koca Yildirim H, et al: Intermediate‑risk factors affecting oncological outcome in patients with FIGO 2018 stage IB2 cervical cancer who do not receive adjuvant therapy. Oncol Lett 29: 308, 2025.
APA
Tokalioglu, A., Oktar, O., Aytekin, O., Alci, A., Kahraman, A., Ege, V. ... Turan, T. (2025). Intermediate‑risk factors affecting oncological outcome in patients with FIGO 2018 stage IB2 cervical cancer who do not receive adjuvant therapy. Oncology Letters, 29, 308. https://doi.org/10.3892/ol.2025.15054
MLA
Tokalioglu, A., Oktar, O., Aytekin, O., Alci, A., Kahraman, A., Ege, V., Kilic, F., Ersak, B., Celik, F., Koca Yildirim, H., Cakir, C., Yuksel, D., Kilic, C., Selcuk, I., Kimyon Comert, G., Boran, N., Basaran, D., Ureyen, I., Toptas, T., Korkmaz, V., Karalok, A., Tasci, T., Moraloglu Tekin, O., Ustun, Y., Ozgul, N., Turan, T."Intermediate‑risk factors affecting oncological outcome in patients with FIGO 2018 stage IB2 cervical cancer who do not receive adjuvant therapy". Oncology Letters 29.6 (2025): 308.
Chicago
Tokalioglu, A., Oktar, O., Aytekin, O., Alci, A., Kahraman, A., Ege, V., Kilic, F., Ersak, B., Celik, F., Koca Yildirim, H., Cakir, C., Yuksel, D., Kilic, C., Selcuk, I., Kimyon Comert, G., Boran, N., Basaran, D., Ureyen, I., Toptas, T., Korkmaz, V., Karalok, A., Tasci, T., Moraloglu Tekin, O., Ustun, Y., Ozgul, N., Turan, T."Intermediate‑risk factors affecting oncological outcome in patients with FIGO 2018 stage IB2 cervical cancer who do not receive adjuvant therapy". Oncology Letters 29, no. 6 (2025): 308. https://doi.org/10.3892/ol.2025.15054
Copy and paste a formatted citation
x
Spandidos Publications style
Tokalioglu A, Oktar O, Aytekin O, Alci A, Kahraman A, Ege V, Kilic F, Ersak B, Celik F, Koca Yildirim H, Koca Yildirim H, et al: Intermediate‑risk factors affecting oncological outcome in patients with FIGO 2018 stage IB2 cervical cancer who do not receive adjuvant therapy. Oncol Lett 29: 308, 2025.
APA
Tokalioglu, A., Oktar, O., Aytekin, O., Alci, A., Kahraman, A., Ege, V. ... Turan, T. (2025). Intermediate‑risk factors affecting oncological outcome in patients with FIGO 2018 stage IB2 cervical cancer who do not receive adjuvant therapy. Oncology Letters, 29, 308. https://doi.org/10.3892/ol.2025.15054
MLA
Tokalioglu, A., Oktar, O., Aytekin, O., Alci, A., Kahraman, A., Ege, V., Kilic, F., Ersak, B., Celik, F., Koca Yildirim, H., Cakir, C., Yuksel, D., Kilic, C., Selcuk, I., Kimyon Comert, G., Boran, N., Basaran, D., Ureyen, I., Toptas, T., Korkmaz, V., Karalok, A., Tasci, T., Moraloglu Tekin, O., Ustun, Y., Ozgul, N., Turan, T."Intermediate‑risk factors affecting oncological outcome in patients with FIGO 2018 stage IB2 cervical cancer who do not receive adjuvant therapy". Oncology Letters 29.6 (2025): 308.
Chicago
Tokalioglu, A., Oktar, O., Aytekin, O., Alci, A., Kahraman, A., Ege, V., Kilic, F., Ersak, B., Celik, F., Koca Yildirim, H., Cakir, C., Yuksel, D., Kilic, C., Selcuk, I., Kimyon Comert, G., Boran, N., Basaran, D., Ureyen, I., Toptas, T., Korkmaz, V., Karalok, A., Tasci, T., Moraloglu Tekin, O., Ustun, Y., Ozgul, N., Turan, T."Intermediate‑risk factors affecting oncological outcome in patients with FIGO 2018 stage IB2 cervical cancer who do not receive adjuvant therapy". Oncology Letters 29, no. 6 (2025): 308. https://doi.org/10.3892/ol.2025.15054
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