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Case Report Open Access

Effective neoadjuvant aumolertinib therapy facilitates transformation of unresectable to resectable advanced non‑small cell lung: A case report

  • Authors:
    • Yao Wang
    • Lubiao Liang
    • Yang Tang
    • Yongxiang Song
    • Gang Xu
    • Xixian Ke
    • Cheng Chen
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 317
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    Published online on: April 28, 2025
       https://doi.org/10.3892/ol.2025.15063
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Abstract

The majority of stage III non‑small cell lung cancer (NSCLC) is unresectable. However, effective treatment may enable patients to transition to resectable NSCLC, thereby extending the progression‑free survival time. The current study presents the case of a female patient with stage IIIC unresectable lung cancer. The patient received icotinib followed by neoadjuvant aumolertinib, resulting in significant tumor shrinkage and downstaging to meet resectability criteria. Despite ~16 months of targeted therapy, including resistance to both first‑ and third‑generation epidermal growth factor receptor‑tyrosine kinase inhibitors, the patient achieved partial remission (PR) and became a candidate for surgical intervention. The patient was successfully transitioned from inoperable stage IIIC cancer to surgically resectable stage IB (ypT2N0M0). Postoperatively, the patient received aumerotinib as adjuvant therapy and is currently undergoing follow‑up visits without evidence of recurrence or metastasis. The present findings provide novel insights into potential treatment choices for patients with inoperable stage IIIC NSCLC, emphasizing the possibility of achieving PR and undergoing surgery despite drug resistance. However, individual variations in such cases necessitate further research and validation before this approach can be widely implemented.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Liang L, Tang Y, Song Y, Xu G, Ke X and Chen C: Effective neoadjuvant aumolertinib therapy facilitates transformation of unresectable to resectable advanced non‑small cell lung: A case report. Oncol Lett 29: 317, 2025.
APA
Wang, Y., Liang, L., Tang, Y., Song, Y., Xu, G., Ke, X., & Chen, C. (2025). Effective neoadjuvant aumolertinib therapy facilitates transformation of unresectable to resectable advanced non‑small cell lung: A case report. Oncology Letters, 29, 317. https://doi.org/10.3892/ol.2025.15063
MLA
Wang, Y., Liang, L., Tang, Y., Song, Y., Xu, G., Ke, X., Chen, C."Effective neoadjuvant aumolertinib therapy facilitates transformation of unresectable to resectable advanced non‑small cell lung: A case report". Oncology Letters 29.6 (2025): 317.
Chicago
Wang, Y., Liang, L., Tang, Y., Song, Y., Xu, G., Ke, X., Chen, C."Effective neoadjuvant aumolertinib therapy facilitates transformation of unresectable to resectable advanced non‑small cell lung: A case report". Oncology Letters 29, no. 6 (2025): 317. https://doi.org/10.3892/ol.2025.15063
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Liang L, Tang Y, Song Y, Xu G, Ke X and Chen C: Effective neoadjuvant aumolertinib therapy facilitates transformation of unresectable to resectable advanced non‑small cell lung: A case report. Oncol Lett 29: 317, 2025.
APA
Wang, Y., Liang, L., Tang, Y., Song, Y., Xu, G., Ke, X., & Chen, C. (2025). Effective neoadjuvant aumolertinib therapy facilitates transformation of unresectable to resectable advanced non‑small cell lung: A case report. Oncology Letters, 29, 317. https://doi.org/10.3892/ol.2025.15063
MLA
Wang, Y., Liang, L., Tang, Y., Song, Y., Xu, G., Ke, X., Chen, C."Effective neoadjuvant aumolertinib therapy facilitates transformation of unresectable to resectable advanced non‑small cell lung: A case report". Oncology Letters 29.6 (2025): 317.
Chicago
Wang, Y., Liang, L., Tang, Y., Song, Y., Xu, G., Ke, X., Chen, C."Effective neoadjuvant aumolertinib therapy facilitates transformation of unresectable to resectable advanced non‑small cell lung: A case report". Oncology Letters 29, no. 6 (2025): 317. https://doi.org/10.3892/ol.2025.15063
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