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Case Report

Chronic myeloid leukemia with the e13a3 atypical fusion gene: A case report

  • Authors:
    • Xin Zhou
    • Meng-Ran Li
    • Ning-Ning Shan
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, P.R. China
  • Article Number: 319
    |
    Published online on: April 28, 2025
       https://doi.org/10.3892/ol.2025.15065
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Abstract

The present report aims to improve our systematic understanding of the clinicopathological characteristics of chronic myeloid leukemia (CML) associated with the e13a3 transcript and to offer insights into potential treatment options for this rare subtype of CML. This case presents a 39‑year‑old male patient of Chinese descent diagnosed with CML featuring an atypical fusion gene identified by the e13a3 transcript. The patient was treated with second‑generation tyrosine kinase inhibitor. An analysis of BCR‑ABL1 using reverse transcription PCR following 6 months of treatment revealed a negative BCR‑ABL1 fusion, indicating deep molecular remission. After 2 years of treatment, the patient developed skin sclerosis. Overall, to prevent missed diagnoses and misdiagnoses, it is recommended that a comprehensive clinical evaluation be performed, and the underlying etiology be proactively identified.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou X, Li M and Shan N: Chronic myeloid leukemia with the e13a3 atypical fusion gene: A case report. Oncol Lett 29: 319, 2025.
APA
Zhou, X., Li, M., & Shan, N. (2025). Chronic myeloid leukemia with the e13a3 atypical fusion gene: A case report. Oncology Letters, 29, 319. https://doi.org/10.3892/ol.2025.15065
MLA
Zhou, X., Li, M., Shan, N."Chronic myeloid leukemia with the e13a3 atypical fusion gene: A case report". Oncology Letters 29.6 (2025): 319.
Chicago
Zhou, X., Li, M., Shan, N."Chronic myeloid leukemia with the e13a3 atypical fusion gene: A case report". Oncology Letters 29, no. 6 (2025): 319. https://doi.org/10.3892/ol.2025.15065
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou X, Li M and Shan N: Chronic myeloid leukemia with the e13a3 atypical fusion gene: A case report. Oncol Lett 29: 319, 2025.
APA
Zhou, X., Li, M., & Shan, N. (2025). Chronic myeloid leukemia with the e13a3 atypical fusion gene: A case report. Oncology Letters, 29, 319. https://doi.org/10.3892/ol.2025.15065
MLA
Zhou, X., Li, M., Shan, N."Chronic myeloid leukemia with the e13a3 atypical fusion gene: A case report". Oncology Letters 29.6 (2025): 319.
Chicago
Zhou, X., Li, M., Shan, N."Chronic myeloid leukemia with the e13a3 atypical fusion gene: A case report". Oncology Letters 29, no. 6 (2025): 319. https://doi.org/10.3892/ol.2025.15065
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