Chronic myeloid leukemia with the e13a3 atypical fusion gene: A case report

  • Authors:
    • Xin Zhou
    • Meng-Ran Li
    • Ning-Ning Shan
  • View Affiliations

  • Published online on: April 28, 2025     https://doi.org/10.3892/ol.2025.15065
  • Article Number: 319
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present report aims to improve our systematic understanding of the clinicopathological characteristics of chronic myeloid leukemia (CML) associated with the e13a3 transcript and to offer insights into potential treatment options for this rare subtype of CML. This case presents a 39‑year‑old male patient of Chinese descent diagnosed with CML featuring an atypical fusion gene identified by the e13a3 transcript. The patient was treated with second‑generation tyrosine kinase inhibitor. An analysis of BCR‑ABL1 using reverse transcription PCR following 6 months of treatment revealed a negative BCR‑ABL1 fusion, indicating deep molecular remission. After 2 years of treatment, the patient developed skin sclerosis. Overall, to prevent missed diagnoses and misdiagnoses, it is recommended that a comprehensive clinical evaluation be performed, and the underlying etiology be proactively identified.
View Figures
View References

Related Articles

Journal Cover

June-2025
Volume 29 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhou X, Li M and Shan N: Chronic myeloid leukemia with the e13a3 atypical fusion gene: A case report. Oncol Lett 29: 319, 2025.
APA
Zhou, X., Li, M., & Shan, N. (2025). Chronic myeloid leukemia with the e13a3 atypical fusion gene: A case report. Oncology Letters, 29, 319. https://doi.org/10.3892/ol.2025.15065
MLA
Zhou, X., Li, M., Shan, N."Chronic myeloid leukemia with the e13a3 atypical fusion gene: A case report". Oncology Letters 29.6 (2025): 319.
Chicago
Zhou, X., Li, M., Shan, N."Chronic myeloid leukemia with the e13a3 atypical fusion gene: A case report". Oncology Letters 29, no. 6 (2025): 319. https://doi.org/10.3892/ol.2025.15065