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Case Report Open Access

Composite B‑cell lymphoma and extranodal natural killer/T‑cell lymphoma presenting with distinct clone evolution and tumor microenvironment: A report of two cases

  • Authors:
    • Qiuyue Wen
    • Qiuhui Li
    • Wei Yang
    • Xiaona Chang
    • Fang Zhu
    • Huaxiong Pan
    • Liling Zhang
  • View Affiliations / Copyright

    Affiliations: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430023, P.R. China, Geneseeq Research Institute, Nanjing Geneseeq Technology Inc., Nanjing, Jiangsu 210032, P.R. China, Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China
    Copyright: © Wen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 320
    |
    Published online on: May 2, 2025
       https://doi.org/10.3892/ol.2025.15066
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Abstract

Composite lymphoma containing both B‑cell lymphoma and extranodal natural killer/T‑cell lymphoma (ENKTL) is extremely rare. Clonal evolution and tumor microenvironment (TME) features have not been reported previously. The present study reports one case of the heterochronous occurrence of follicular lymphoma (FL) and ENKTL and one case of the simultaneous occurrence of diffuse large B‑cell lymphoma (DLBCL) and ENKTL. The results of targeted DNA sequencing demonstrated the genetic features and dynamic clonal evolution of each component. Notably, in the case of ENKTL secondary from FL, predominant clones harbored in ENKTL were already present at the initial diagnosis of FL and expanded to full clonal prevalence afterward in ENKTL. In the case of synchronous DLBCL and ENKTL, predominant clones in ENKTL were exclusive to those clones dominating in DLBCL. Multiple immunofluorescence and CIBERSORT analyses depicted TME features and showed that CD68+ macrophages were abundant in FL, DLBCL and ENKTL. The present report could broaden our understanding of composite lymphoma.
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Copy and paste a formatted citation
Spandidos Publications style
Wen Q, Li Q, Yang W, Chang X, Zhu F, Pan H and Zhang L: Composite B‑cell lymphoma and extranodal natural killer/T‑cell lymphoma presenting with distinct clone evolution and tumor microenvironment: A report of two cases. Oncol Lett 30: 320, 2025.
APA
Wen, Q., Li, Q., Yang, W., Chang, X., Zhu, F., Pan, H., & Zhang, L. (2025). Composite B‑cell lymphoma and extranodal natural killer/T‑cell lymphoma presenting with distinct clone evolution and tumor microenvironment: A report of two cases. Oncology Letters, 30, 320. https://doi.org/10.3892/ol.2025.15066
MLA
Wen, Q., Li, Q., Yang, W., Chang, X., Zhu, F., Pan, H., Zhang, L."Composite B‑cell lymphoma and extranodal natural killer/T‑cell lymphoma presenting with distinct clone evolution and tumor microenvironment: A report of two cases". Oncology Letters 30.1 (2025): 320.
Chicago
Wen, Q., Li, Q., Yang, W., Chang, X., Zhu, F., Pan, H., Zhang, L."Composite B‑cell lymphoma and extranodal natural killer/T‑cell lymphoma presenting with distinct clone evolution and tumor microenvironment: A report of two cases". Oncology Letters 30, no. 1 (2025): 320. https://doi.org/10.3892/ol.2025.15066
Copy and paste a formatted citation
x
Spandidos Publications style
Wen Q, Li Q, Yang W, Chang X, Zhu F, Pan H and Zhang L: Composite B‑cell lymphoma and extranodal natural killer/T‑cell lymphoma presenting with distinct clone evolution and tumor microenvironment: A report of two cases. Oncol Lett 30: 320, 2025.
APA
Wen, Q., Li, Q., Yang, W., Chang, X., Zhu, F., Pan, H., & Zhang, L. (2025). Composite B‑cell lymphoma and extranodal natural killer/T‑cell lymphoma presenting with distinct clone evolution and tumor microenvironment: A report of two cases. Oncology Letters, 30, 320. https://doi.org/10.3892/ol.2025.15066
MLA
Wen, Q., Li, Q., Yang, W., Chang, X., Zhu, F., Pan, H., Zhang, L."Composite B‑cell lymphoma and extranodal natural killer/T‑cell lymphoma presenting with distinct clone evolution and tumor microenvironment: A report of two cases". Oncology Letters 30.1 (2025): 320.
Chicago
Wen, Q., Li, Q., Yang, W., Chang, X., Zhu, F., Pan, H., Zhang, L."Composite B‑cell lymphoma and extranodal natural killer/T‑cell lymphoma presenting with distinct clone evolution and tumor microenvironment: A report of two cases". Oncology Letters 30, no. 1 (2025): 320. https://doi.org/10.3892/ol.2025.15066
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