Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2025 Volume 30 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2025 Volume 30 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Retroperitoneal growth of high‑grade serous ovarian carcinoma: A case report

  • Authors:
    • Pengnan Hu
    • Weizhou Pan
    • Jun Yu
    • Hua Mi
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 335
    |
    Published online on: May 9, 2025
       https://doi.org/10.3892/ol.2025.15081
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

High‑grade serous ovarian carcinoma (HGSOC), an epithelial ovarian carcinoma, is primarily believed to originate from fallopian tube epithelial cells. This site of origin facilitates the dissemination of tumor cells to retroperitoneal organs or tissues, unrestricted by anatomical barriers, thereby promoting metastasis. The present report describes a rare case of HGSOC presenting with retroperitoneal involvement, and provides a comprehensive literature review on its pathogenesis, symptoms, diagnostic methods, treatment strategies and prognosis. The critical role of timely abdominal and pelvic imaging, along with tumor marker analysis, to evaluate patients with retroperitoneal tumors and nonspecific symptoms is emphasized. This approach aids in identifying the origin of retroperitoneal masses and facilitates the early diagnosis of metastatic HGSOC. Notably, an elevated serum CA125 level should raise suspicion of an ovarian malignancy.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Lisio MA, Fu L, Goyeneche A, Gao ZH and Telleria C: High-grade serous ovarian cancer: Basic sciences, clinical and therapeutic standpoints. Int J Mol Sci. 20:9522019. View Article : Google Scholar : PubMed/NCBI

2 

Bast RC Jr, Hennessy B and Mills GB: The biology of ovarian cancer: New opportunities for translation. Nat Rev Cancer. 9:415–428. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Lengyel E: Ovarian cancer development and metastasis. Am J Pathol. 177:1053–1064. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Matulonis UA, Sood AK, Fallowfield L, Howitt BE, Sehouli J and Karlan BY: Ovarian cancer. Nat Rev Dis Primers. 2:160612016. View Article : Google Scholar : PubMed/NCBI

6 

Kurman RJ, Carcangiu ML, Herrington CS and Young RH: WHO Classification of Tumours of Female Reproductive Organs. 4th edition. WHO; Geneva, Switzerland: 2014

7 

Ohman AW, Hasan N and Dinulescu DM: Advances in tumor screening, imaging, and avatar technologies for high-grade serous ovarian cancer. Front Oncol. 4:3222014. View Article : Google Scholar : PubMed/NCBI

8 

National Cancer Institute Surveillance, Epidemiology and End Results Program, . Cancer Stat Facts: Ovarian Cancer. https://seer.cancer.gov/statfacts/html/ovary.htmlMay 26–2018

9 

Gilbert L, Basso O, Sampalis J, Karp I, Martins C, Feng J, Piedimonte S, Quintal L, Ramanakumar AV, Takefman J, et al: Assessment of symptomatic women for early diagnosis of ovarian cancer: Results from the prospective DOvE pilot project. Lancet Oncol. 13:285–291. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Narod S: Can advanced-stage ovarian cancer be cured? Nat Rev Clin Oncol. 13:255–261. 2016. View Article : Google Scholar : PubMed/NCBI

11 

The American College of Obstetricians and Gynecologists, . Five Things Physicians and Patients Should Question. Choosing Wisely; 2013

12 

Menon U, Gentry-Maharaj A, Hallett R, Ryan A, Burnell M, Sharma A, Lewis S, Davies S, Philpott S, Lopes A, et al: Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: Results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Lancet Oncol. 10:327–340. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Buys SS, Partridge E, Black A, Johnson CC, Lamerato L, Isaacs C, Reding DJ, Greenlee RT, Yokochi LA, Kessel B, et al: Effect of screening on ovarian cancer mortality: The prostate, lung, colorectal and ovarian (PLCO) cancer screening randomized controlled trial. JAMA. 305:2295–2302. 2011. View Article : Google Scholar : PubMed/NCBI

14 

van Altena AM, Kolwijck E, Spanjer MJ, Hendriks JC, Massuger LF and de Hullu JA: CA125 nadir concentration is an independent predictor of tumor recurrence in patients with ovarian cancer: A population-based study. Gynecol Oncol. 119:265–269. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Jayson GC, Kohn EC, Kitchener HC and Ledermann JA: Ovarian cancer. Lancet. 384:1376–1388. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Piatek S, Panek G, Lewandowski Z, Piatek D, Kosinski P and Bidzinski M: Nadir CA-125 has prognostic value for recurrence, but not for survival in patients with ovarian cancer. Sci Rep. 11:181902021. View Article : Google Scholar : PubMed/NCBI

17 

Bates M, Mohamed BM, Lewis F, O'Toole S and O'Leary JJ: Biomarkers in high grade serous ovarian cancer. Biochim Biophys Acta Rev Cancer. 1879:1892242024. View Article : Google Scholar : PubMed/NCBI

18 

Markman M: Optimizing primary chemotherapy in ovarian cancer. Hematol Oncol Clin North Am. 17:957–968. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Vergote I, Tropé CG, Amant F, Kristensen GB, Ehlen T, Johnson N, Verheijen RH, van der Burg ME, Lacave AJ, Panici PB, et al: Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer. N Engl J Med. 363:943–953. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Kehoe S, Hook J, Nankivell M, Jayson GC, Kitchener H, Lopes T, Luesley D, Perren T, Bannoo S, Mascarenhas M, et al: Primary chemotherapy versus primary surgery for newly diagnosed advanced ovarian cancer (CHORUS): An open-label, randomised, controlled, non-inferiority trial. Lancet. 386:249–257. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Denkert C, Loibl S, Müller B, Eidtmann H, Schmitt W, Eiermann W, Gerber B, Tesch H, Hilfrich J, Huober J, et al: Ki67 levels as predictive and prognostic parameters in pretherapeutic breast cancer core biopsies: A translational investigation in the neoadjuvant GeparTrio trial. Ann Oncol. 24:2786–2793. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Qi X, Zhang F, Wu H, Liu J, Zong B, Xu C and Jiang J: Wilms' tumor 1 (WT1) expression and prognosis in solid cancer patients: A systematic review and meta-analysis. Sci Rep. 5:89242015. View Article : Google Scholar : PubMed/NCBI

23 

Reuschenbach M, Rafiyan M, Karbach J, Pauligk C, Faulstich F, Sauer M, Prigge ES, Kloor M, Al-Batran S, Kaufmann AM, et al: Phase I/IIa study of therapeutic p16INK4a vaccination in patients with HPV-associated cancers. J Clin Oncol. 32:3092–3097. 2014. View Article : Google Scholar

24 

Rice JC, Ozcelik H, Maxeiner P, Andrulis I and Futscher BW: Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens. Carcinogenesis. 21:1761–1765. 2000. View Article : Google Scholar : PubMed/NCBI

25 

National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology, . Ovarian Cancer, version 1.2023. National Comprehensive Cancer Network; 2023, https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1453February 15–2025

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hu P, Pan W, Yu J and Mi H: Retroperitoneal growth of high‑grade serous ovarian carcinoma: A case report. Oncol Lett 30: 335, 2025.
APA
Hu, P., Pan, W., Yu, J., & Mi, H. (2025). Retroperitoneal growth of high‑grade serous ovarian carcinoma: A case report. Oncology Letters, 30, 335. https://doi.org/10.3892/ol.2025.15081
MLA
Hu, P., Pan, W., Yu, J., Mi, H."Retroperitoneal growth of high‑grade serous ovarian carcinoma: A case report". Oncology Letters 30.1 (2025): 335.
Chicago
Hu, P., Pan, W., Yu, J., Mi, H."Retroperitoneal growth of high‑grade serous ovarian carcinoma: A case report". Oncology Letters 30, no. 1 (2025): 335. https://doi.org/10.3892/ol.2025.15081
Copy and paste a formatted citation
x
Spandidos Publications style
Hu P, Pan W, Yu J and Mi H: Retroperitoneal growth of high‑grade serous ovarian carcinoma: A case report. Oncol Lett 30: 335, 2025.
APA
Hu, P., Pan, W., Yu, J., & Mi, H. (2025). Retroperitoneal growth of high‑grade serous ovarian carcinoma: A case report. Oncology Letters, 30, 335. https://doi.org/10.3892/ol.2025.15081
MLA
Hu, P., Pan, W., Yu, J., Mi, H."Retroperitoneal growth of high‑grade serous ovarian carcinoma: A case report". Oncology Letters 30.1 (2025): 335.
Chicago
Hu, P., Pan, W., Yu, J., Mi, H."Retroperitoneal growth of high‑grade serous ovarian carcinoma: A case report". Oncology Letters 30, no. 1 (2025): 335. https://doi.org/10.3892/ol.2025.15081
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team