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Evolving role of deubiquitinating enzymes in oral cancer (Review)

  • Authors:
    • Zidi Wang
    • Siyuan Cheng
    • Jianhui Wei
    • Jiandong Hu
    • Fenge Li
    • Wenhua Yang
  • View Affiliations / Copyright

    Affiliations: Department of Dentistry, Tianjin Beichen Hospital, Tianjin 300400, P.R. China, Department of Oncology, Tianjin Beichen Hospital, Tianjin 300400, P.R. China, Core Laboratory, Tianjin Beichen Hospital, Tianjin 300400, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 354
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    Published online on: May 19, 2025
       https://doi.org/10.3892/ol.2025.15100
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Abstract

Oral cancer affects the mucosal epithelium located within the oral cavity. The prevalence of oral cancer is projected to increase by ~40% by 2040, leading to a subsequent rise in mortality rates. Oral carcinogenesis is complex and multifactorial and numerous signaling pathways are involved in disease development. Deubiquitination is commonly involved in the post‑translational process of proteins, and serves a key role in tumorigenesis and cancer development. The present review aims to discuss the function of deubiquitinating enzymes (DUBs) in oral cancer, with a particular focus on oral squamous cell carcinoma (OSCC). The present review also aims to investigate the functional mechanisms, tumorigenic regulation and therapeutic targets of DUBs in OSCC, which may potentially provide a novel theoretical basis for the utilization of DUBs as molecular targets in the treatment of OSCC in the future.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Z, Cheng S, Wei J, Hu J, Li F and Yang W: Evolving role of deubiquitinating enzymes in oral cancer (Review). Oncol Lett 30: 354, 2025.
APA
Wang, Z., Cheng, S., Wei, J., Hu, J., Li, F., & Yang, W. (2025). Evolving role of deubiquitinating enzymes in oral cancer (Review). Oncology Letters, 30, 354. https://doi.org/10.3892/ol.2025.15100
MLA
Wang, Z., Cheng, S., Wei, J., Hu, J., Li, F., Yang, W."Evolving role of deubiquitinating enzymes in oral cancer (Review)". Oncology Letters 30.1 (2025): 354.
Chicago
Wang, Z., Cheng, S., Wei, J., Hu, J., Li, F., Yang, W."Evolving role of deubiquitinating enzymes in oral cancer (Review)". Oncology Letters 30, no. 1 (2025): 354. https://doi.org/10.3892/ol.2025.15100
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Z, Cheng S, Wei J, Hu J, Li F and Yang W: Evolving role of deubiquitinating enzymes in oral cancer (Review). Oncol Lett 30: 354, 2025.
APA
Wang, Z., Cheng, S., Wei, J., Hu, J., Li, F., & Yang, W. (2025). Evolving role of deubiquitinating enzymes in oral cancer (Review). Oncology Letters, 30, 354. https://doi.org/10.3892/ol.2025.15100
MLA
Wang, Z., Cheng, S., Wei, J., Hu, J., Li, F., Yang, W."Evolving role of deubiquitinating enzymes in oral cancer (Review)". Oncology Letters 30.1 (2025): 354.
Chicago
Wang, Z., Cheng, S., Wei, J., Hu, J., Li, F., Yang, W."Evolving role of deubiquitinating enzymes in oral cancer (Review)". Oncology Letters 30, no. 1 (2025): 354. https://doi.org/10.3892/ol.2025.15100
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