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Review Open Access

IGFBP3 modulation of tumor pathogenesis and cell signaling pathways (Review)

  • Authors:
    • Yanzi Zhang
    • Xin Lv
  • View Affiliations / Copyright

    Affiliations: Clinical Laboratory, Children's Hospital Affiliated to Shandong University, Jinan, Shandong 250022, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 379
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    Published online on: June 3, 2025
       https://doi.org/10.3892/ol.2025.15125
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Abstract

Insulin‑like growth factor binding protein 3 (IGFBP3) is the primary carrier of circulating insulin‑like growth factors and is the most extensively studied protein among the six high‑affinity insulin‑like growth factor binding proteins. Alterations in IGFBP3 at both the transcriptional and post‑translational levels may contribute to the occurrence and progression of tumors. The present review focused on the changes in expression levels of IGFBP3 in tumors, as well as the relationship between the activation and inhibition of associated cell signaling pathways, and alterations in cellular biological behavior, aiming to provide a reference for the precise treatment of tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y and Lv X: IGFBP3 modulation of tumor pathogenesis and cell signaling pathways (Review). Oncol Lett 30: 379, 2025.
APA
Zhang, Y., & Lv, X. (2025). IGFBP3 modulation of tumor pathogenesis and cell signaling pathways (Review). Oncology Letters, 30, 379. https://doi.org/10.3892/ol.2025.15125
MLA
Zhang, Y., Lv, X."IGFBP3 modulation of tumor pathogenesis and cell signaling pathways (Review)". Oncology Letters 30.2 (2025): 379.
Chicago
Zhang, Y., Lv, X."IGFBP3 modulation of tumor pathogenesis and cell signaling pathways (Review)". Oncology Letters 30, no. 2 (2025): 379. https://doi.org/10.3892/ol.2025.15125
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y and Lv X: IGFBP3 modulation of tumor pathogenesis and cell signaling pathways (Review). Oncol Lett 30: 379, 2025.
APA
Zhang, Y., & Lv, X. (2025). IGFBP3 modulation of tumor pathogenesis and cell signaling pathways (Review). Oncology Letters, 30, 379. https://doi.org/10.3892/ol.2025.15125
MLA
Zhang, Y., Lv, X."IGFBP3 modulation of tumor pathogenesis and cell signaling pathways (Review)". Oncology Letters 30.2 (2025): 379.
Chicago
Zhang, Y., Lv, X."IGFBP3 modulation of tumor pathogenesis and cell signaling pathways (Review)". Oncology Letters 30, no. 2 (2025): 379. https://doi.org/10.3892/ol.2025.15125
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