Open Access

Role of the period family in mediating the interplay between circadian disruption and cancer (Review)

  • Authors:
    • Pengfei Gu
    • Wenjian Xu
    • Xiaorui Fan
    • Qiang Gao
    • Yukun Wei
    • Haojie Zhang
    • Yuzhen Cui
    • Yong Han
  • View Affiliations

  • Published online on: June 10, 2025     https://doi.org/10.3892/ol.2025.15137
  • Article Number: 391
  • Copyright: © Gu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The circadian clock, which is based on 24‑h cyclical changes in the external environment, can be detected in almost all cells and regulates several vital physiological processes. The circadian rhythm is disrupted in numerous individuals for several reasons, such as shift work, chronic jet lag, high fat intake and abnormal sleep patterns. Disruption of the circadian rhythm can increase the risk of cancer, affecting its development and treatment. The Period gene family is a core component of the circadian rhythm cycle, and the mechanisms by which its changes affect cancer progression are unclear. The present study reviewed the current research on the intricate relationship between disruption of the circadian clock, particularly focusing on the Period gene family, and its effect on the occurrence, progression and therapeutic approaches for cancer.
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August-2025
Volume 30 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Gu P, Xu W, Fan X, Gao Q, Wei Y, Zhang H, Cui Y and Han Y: Role of the period family in mediating the interplay between circadian disruption and cancer (Review). Oncol Lett 30: 391, 2025.
APA
Gu, P., Xu, W., Fan, X., Gao, Q., Wei, Y., Zhang, H. ... Han, Y. (2025). Role of the period family in mediating the interplay between circadian disruption and cancer (Review). Oncology Letters, 30, 391. https://doi.org/10.3892/ol.2025.15137
MLA
Gu, P., Xu, W., Fan, X., Gao, Q., Wei, Y., Zhang, H., Cui, Y., Han, Y."Role of the period family in mediating the interplay between circadian disruption and cancer (Review)". Oncology Letters 30.2 (2025): 391.
Chicago
Gu, P., Xu, W., Fan, X., Gao, Q., Wei, Y., Zhang, H., Cui, Y., Han, Y."Role of the period family in mediating the interplay between circadian disruption and cancer (Review)". Oncology Letters 30, no. 2 (2025): 391. https://doi.org/10.3892/ol.2025.15137