Open Access

Telomere length and skin cancer risk: A systematic review and meta‑analysis of melanoma, basal cell carcinoma and squamous cell carcinoma

  • Authors:
    • Dimitrios A. Andreikos
    • Demetrios A. Spandidos
  • View Affiliations

  • Published online on: June 12, 2025     https://doi.org/10.3892/ol.2025.15141
  • Article Number: 395
  • Copyright: © Andreikos et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Skin cancer is one of the most prevalent types of cancer worldwide, with its global incidence rising despite prevention efforts. Telomere length (TL) has emerged as a potential biomarker for cancer risk; however, its relationship with skin cancer risk remains incompletely understood. To explore the association between TL and the risk of melanoma, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), a systematic review and meta‑analysis was conducted. Longer TL was significantly associated with an increased risk in melanoma (pooled odds ratio: 0.51; 95% confidence interval: 0.38‑0.69; P<0.0001). A significant association between longer TL and increased melanoma risk was identified in both familial melanoma and the general population. Subgroup analyses revealed consistent associations across sex, population source and adjustments for confounding factors. Geographic stratification indicated stronger associations in studies conducted in the USA compared with those from European populations. A meta‑analysis of BCC and SCC studies did not achieve statistical significance, although qualitative synthesis suggested a potential association between shortened TL and increased risk. The significant association of longer TL and increased melanoma risk diverges from the conventional hypothesis that telomere shortening elevates cancer risk, highlighting a cancer‑type specific telomeric relationship. The inconclusive findings for BCC and SCC underscore the necessity for further detailed investigation. Large‑scale prospective studies with standardized methodologies are imperative to validate these findings and explore the underlying mechanisms. The present findings suggested that TL could potentially serve as a valuable biomarker for melanoma risk stratification in dermatologic oncology. 
View Figures
View References

Related Articles

Journal Cover

August-2025
Volume 30 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Andreikos DA and Spandidos DA: Telomere length and skin cancer risk: A systematic review and meta‑analysis of melanoma, basal cell carcinoma and squamous cell carcinoma. Oncol Lett 30: 395, 2025.
APA
Andreikos, D.A., & Spandidos, D.A. (2025). Telomere length and skin cancer risk: A systematic review and meta‑analysis of melanoma, basal cell carcinoma and squamous cell carcinoma. Oncology Letters, 30, 395. https://doi.org/10.3892/ol.2025.15141
MLA
Andreikos, D. A., Spandidos, D. A."Telomere length and skin cancer risk: A systematic review and meta‑analysis of melanoma, basal cell carcinoma and squamous cell carcinoma". Oncology Letters 30.2 (2025): 395.
Chicago
Andreikos, D. A., Spandidos, D. A."Telomere length and skin cancer risk: A systematic review and meta‑analysis of melanoma, basal cell carcinoma and squamous cell carcinoma". Oncology Letters 30, no. 2 (2025): 395. https://doi.org/10.3892/ol.2025.15141