Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2025 Volume 30 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2025 Volume 30 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Functions and mechanisms of long non‑coding RNA in esophageal squamous cell carcinoma (Review)

  • Authors:
    • Yuning Lin
    • Zhenyi Lv
    • Hongyan Xie
    • Wenzhen Zhao
    • Ruonan Pu
    • Zhongying Zhang
    • Hongwei Jin
  • View Affiliations / Copyright

    Affiliations: Medical Laboratory, Xiamen Humanity Hospital Fujian Medical University, Xiamen, Fujian 361009, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 418
    |
    Published online on: July 1, 2025
       https://doi.org/10.3892/ol.2025.15164
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Esophageal cancer (EC) is a highly prevalent and lethal malignancy of the digestive system, characterized by a complex pathogenesis involving multigene abnormalities and epigenetic regulation. Long non‑coding RNAs (lncRNAs) are key regulatory elements in esophageal squamous cell carcinoma (ESCC). lncRNAs, defined as ncRNA molecules >200 nucleotides in length, modulate gene expression through diverse mechanisms, including epigenetic modification, competing endogenous RNA networks and RNA‑protein interactions. lncRNAs participate in regulating key biological processes in ESCC, such as tumor cell proliferation, invasion, metastasis, apoptosis, drug resistance, radioresistance, stem cell properties and epithelial‑mesenchymal transition. The present review summarizes the regulatory roles of lncRNAs in ESCC pathophysiology and their potential clinical application, emphasizing specific regulatory axes and mechanistic pathways implicated in esophageal carcinogenesis. Future studies should explore the molecular mechanisms of lncRNAs and their translational application to improve prognostic outcomes for patients with ESCC and identify novel therapeutic targets. These efforts may provide innovative strategies and directions for advancing precision oncology in ESCC management.
View Figures

Figure 1

Function of lncRNAs in esophageal
cancer. LncRNAs are involved in regulating key biological processes
in esophageal squamous cell carcinoma, such as tumor cell
proliferation, invasion, metastasis, apoptosis, drug resistance,
radiation resistance, stem cell characteristics and EMT. MiRNA,
microRNA; LncRNA, long non-coding RNA; EMT, epithelial-mesenchymal
transition.

Figure 2

Potential lncRNA candidate markers in
esophageal cancer. LncRNA, long non-coding RNA; SNHG1, small
nucleolar RNA host gene 12; VPS9D1, VPS9 domain containing 1;
EWSAT1, Ewing sarcoma associated transcript 1; PINT, p53 induced
transcript; HAND2, heart and neural crest derivatives expressed 2;
NEF, negative regulatory factor; PGM5, phosphoglucomutase 5; CCAT1,
colon cancer associated transcript 2; DDX11, DEAD/H-box helicase
11; FOXD2, forkhead box D2; HCP5, HLA complex P5; IRF1, interferon
regulatory factor 1; MAGI2, membrane associated guanylate kinase,
WW and PDZ domain containing 2; MEG3, maternally expressed 3.
View References

1 

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I and Jemal A: Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 74:229–263. 2024. View Article : Google Scholar : PubMed/NCBI

2 

Teng Y, Xia C, Cao M, Yang F, Yan X, He S, Cao M, Zhang S, Li Q, Tan N, et al: Esophageal cancer global burden profiles, trends, and contributors. Cancer Biol Med. 21:656–666. 2024.PubMed/NCBI

3 

Prabhu A, Obi KO and Rubenstein JH: The synergistic effects of alcohol and tobacco consumption on the risk of esophageal squamous cell carcinoma: A meta-analysis. Am J Gastroenterol. 109:822–827. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Islami F, Ren JS, Taylor PR and Kamangar F: Pickled vegetables and the risk of oesophageal cancer: A meta-analysis. Br J Cancer. 101:641–1647. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Li B, Jiang G, Zhang G, Xue Q, Zhang H, Wang C and Zhao T: Intake of vegetables and fruit and risk of esophageal adenocarcinoma: A meta-analysis of observational studies. Eur J Nutr. 53:1511–1521. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Wong MCS, Deng Y, Huang J, Bai Y, Wang HHX, Yuan J, Zhang L, Yip HC and Chiu PWY: Performance of screening tests for esophageal squamous cell carcinoma: A systematic review and meta-analysis. Gastrointest Endosc. 96:197–207.e34. 2022. View Article : Google Scholar : PubMed/NCBI

7 

Min Q, Zhang M, Lin D, Zhang W, Li X, Zhao L, Teng H, He T, Sun W, Fan J, et al: Genomic characterization and risk stratification of esophageal squamous dysplasia. Med Rev. 4:244–256. 2024. View Article : Google Scholar

8 

Sasaki F, Kanmura S, Oda K, Maeda H, Kabayama M, Iwaya H, Komaki Y, Arima S, Tanoue S, Hashimoto S, et al: Acetaldehyde breath test as a cancer risk marker in patients with esophageal and hypopharyngeal squamous cell carcinoma. PLoS One. 16:e02514572021. View Article : Google Scholar : PubMed/NCBI

9 

Li K, Lin Y, Zhou Y, Xiong X, Wang L, Li J, Zhou F, Guo Y, Chen S, Chen Y, et al: Salivary extracellular MicroRNAs for early detection and prognostication of esophageal cancer: A clinical study. Gastroenterology. 165:932–945.e9. 2023. View Article : Google Scholar : PubMed/NCBI

10 

Wang X, Yu N, Cheng G, Zhang T, Wang J, Deng L, Li J, Zhao X, Xu Y, Yang P, et al: Prognostic value of circulating tumour DNA during post-radiotherapy surveillance in locally advanced esophageal squamous cell carcinoma. Clin Transl Med. 12:e11162022. View Article : Google Scholar : PubMed/NCBI

11 

Su M, Xiao Y, Ma J, Cao D, Zhou Y, Wang H, Liao Q and Wang W: Long non-coding RNAs in esophageal cancer: Molecular mechanisms, functions, and potential applications. J Hematol Oncol. 11:1182018. View Article : Google Scholar : PubMed/NCBI

12 

Yan Q, Wong W, Gong L, Yang J, Liang D, Chin KY, Dai S and Wang J: Roles of long non-coding RNAs in esophageal cell squamous carcinoma (Review). Int J Mol Med. 54:722024. View Article : Google Scholar : PubMed/NCBI

13 

Li H, Jia J, Yang L, Chu J, Sheng J, Wang C, Meng W, Jia Z, Yin H, Wan J and He F: LncRNA MIR205HG drives esophageal squamous cell carcinoma progression by regulating miR-214/SOX4 axis. Onco Targets Ther. 13:13097–13109. 2020. View Article : Google Scholar : PubMed/NCBI

14 

Jia J, Li H, Chu J, Sheng J, Wang C, Jia Z, Meng W, Yin H, Wa J and He F: LncRNA FAM83A-AS1 promotes ESCC progression by regulating miR-214/CDC25B axis. J Cancer. 12:1200–1211. 2021. View Article : Google Scholar : PubMed/NCBI

15 

Zhao Y, Zhang Q, Liu H, Wang N, Zhang X and Yang S: lncRNA PART1, manipulated by transcriptional factor FOXP2, suppresses proliferation and invasion in ESCC by regulating the miR-18a-5p/SOX6 signaling axis. Oncol Rep. 45:1118–1132. 2021. View Article : Google Scholar : PubMed/NCBI

16 

Li Z, Qin X, Bian W, Li Y, Shan B, Yao Z and Li S: Exosomal lncRNA ZFAS1 regulates esophageal squamous cell carcinoma cell proliferation, invasion, migration and apoptosis via microRNA-124/STAT3 axis. J Exp Clin Cancer Res. 38:4772019. View Article : Google Scholar : PubMed/NCBI

17 

Wang L, Ren X, Ma X, Yin L, Niu X and Xing S: LncRNA OIP5-AS1 promotes the development of esophageal squamous cell carcinoma by binding to miR-1297. Panminerva Med. 64:589–590. 2022. View Article : Google Scholar : PubMed/NCBI

18 

Lin P, Li Q, Lv X, Qu J, Wang D, Li A and Jiang G: HMGA1 promotes the development of esophageal squamous cell carcinoma by mediating miR-671-5p/lncRNA DLEU1. Panminerva Med. 65:264–266. 2023. View Article : Google Scholar : PubMed/NCBI

19 

Tang J, Xu H, Liu Q, Zheng J, Pan C, Li Z, Wen W, Wang J, Zhu Q, Wang Z and Chen L: LncRNA LOC146880 promotes esophageal squamous cell carcinoma progression via miR-328-5p/FSCN1/MAPK axis. Aging (Albany NY). 13:14198–14218. 2021. View Article : Google Scholar : PubMed/NCBI

20 

Xu ML, Liu TC, Dong FX, Meng LX, Ling AX and Liu S: Exosomal lncRNA LINC01711 facilitates metastasis of esophageal squamous cell carcinoma via the miR-326/FSCN1 axis. Aging (Albany NY). 13:19776–19788. 2021. View Article : Google Scholar : PubMed/NCBI

21 

Wang Y, Zhang W, Liu W, Huang L, Wang Y, Li D, Wang G, Zhao Z, Chi X, Xue Y, et al: Long noncoding RNA VESTAR regulates lymphangiogenesis and lymph node metastasis of esophageal squamous cell carcinoma by enhancing VEGFC mRNA stability. Cancer Res. 81:3187–3199. 2021. View Article : Google Scholar : PubMed/NCBI

22 

Xu ML, Liu TC, Dong FX, Meng LX, Ling AX and Liu S: BBOX1-AS1 activates hedgehog signaling pathway to facilitate the proliferation and stemness of esophageal squamous cell carcinoma cells via miR-506-5p/EIF5A/PTCH1 axis. Curr Mol Pharmacol. 16:894–904. 2023.PubMed/NCBI

23 

Zhang Y, Liu D, Guo D, Lin W, Lu W, Hu L, Chen S and Chen C: CPSF3 regulates alternative polyadenylation of CNIH2 to promote esophageal squamous cell carcinoma progression. Cancer Lett. 593:2169252024. View Article : Google Scholar : PubMed/NCBI

24 

Cheng W, Shi X, Lin M, Yao Q, Ma J and Li J: LncRNA MAGI2-AS3 overexpression sensitizes esophageal cancer cells to irradiation through Down-regulation of HOXB7 via EZH2. Front Cell Dev Biol. 8:5528222020. View Article : Google Scholar : PubMed/NCBI

25 

Liu S, Li X, Xie Q, Zhang S, Liang X, Li S and Zhang P: Identification of a lncRNA/circRNA-miRNA-mRNA network in Nasopharyngeal Carcinoma by deep sequencing and bioinformatics analysis. J Cancer. 15:1916–1928. 2024. View Article : Google Scholar : PubMed/NCBI

26 

Wang Z, Huang YF, Yu L and Jiao Y: sh-HNF1A-AS1 reduces the epithelial-mesenchymal transition and stemness of esophageal cancer cells. Neoplasma. 69:560–570. 2022. View Article : Google Scholar : PubMed/NCBI

27 

Chen L, Lu J, Li X, Wang X, Qiao R, Guo W and Ren Q: LncRNA KTN1-AS1 facilitates esophageal squamous cell carcinoma progression via miR-885-5p/STRN3 axis. Genes Genomics. 46:241–252. 2024. View Article : Google Scholar : PubMed/NCBI

28 

Li P, Ding H, Han S, Ding S and Yang Y: Long noncoding RNA LINC00858 aggravates the progression of esophageal squamous cell carcinoma via regulating the miR-425-5p/ABL2 axis. Heliyon. 10:e273372024. View Article : Google Scholar : PubMed/NCBI

29 

Wu D, He X, Wang W, Hu X, Wang K and Wang M: Long noncoding RNA SNHG12 induces proliferation, migration, epithelial-mesenchymal transition, and stemness of esophageal squamous cell carcinoma cells via post-transcriptional regulation of BMI1 and CTNNB1. Mol Oncol. 14:2332–2351. 2020. View Article : Google Scholar : PubMed/NCBI

30 

Li S, Lv C, Li J, Xie T, Liu X, Zheng Z, Qin Z, Hui X and Yu Y: LncRNA LINC00473 promoted colorectal cancer cell proliferation and invasion by targeting miR-195 expression. Am J Transl Res. 13:6066–6075. 2021.PubMed/NCBI

31 

Song B, Wei F, Peng J, Wei X, Liu M, Nie Z, Ma Y and Peng T: Icariin regulates EMT and stem Cell-like character in breast cancer through modulating lncRNA NEAT1/TGFβ/SMAD2 signaling pathway. Biol Pharm Bull. 47:399–410. 2024. View Article : Google Scholar : PubMed/NCBI

32 

Huang H, Huang F, Liang X, Fu Y, Cheng Z, Huang Y, Chen Z, Duan Y and Chen Y: Afatinib reverses EMT via inhibiting CD44-Stat3 axis to promote radiosensitivity in nasopharyngeal carcinoma. Pharmaceuticals (Basel). 16:372022. View Article : Google Scholar : PubMed/NCBI

33 

Wu Y, Hu L, Liang Y, Li J, Wang K, Chen X, Meng H, Guan X, Yang K and Bai Y: Up-regulation of lncRNA CASC9 promotes esophageal squamous cell carcinoma growth by negatively regulating PDCD4 expression through EZH2. Mol Cancer. 16:1502017. View Article : Google Scholar : PubMed/NCBI

34 

Cui Y, Zhang C, Ma S, Li Z, Wang W, Li Y, Ma Y, Fang J, Wang Y, Cao W and Guan F: RNA m6A demethylase FTO-mediated epigenetic up-regulation of LINC00022 promotes tumorigenesis in esophageal squamous cell carcinoma. J Exp Clin Cancer Res. 40:2942021. View Article : Google Scholar : PubMed/NCBI

35 

Zhang S, Liang Y, Wu Y, Chen X, Wang K, Li J, Guan X, Xiong G, Yang K, Bai Y, et al: Upregulation of a novel lncRNA LINC01980 promotes tumor growth of esophageal squamous cell carcinoma. Biochem Biophys Res Commun. 513:73–80. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Wang M, Wang L, He X, Zhang J, Zhu Z, Zhang M and Li X: lncRNA CCAT2 promotes radiotherapy resistance for human esophageal carcinoma cells via the miR-145/p70S6K1 and p53 pathway. Int J Oncol. 56:327–336. 2020.PubMed/NCBI

37 

Wu Q, Zhang H, Yang D, Min Q, Wang Y, Zhang W and Zhan Q: The m6A-induced lncRNA CASC8 promotes proliferation and chemoresistance via upregulation of hnRNPL in esophageal squamous cell carcinoma. Int J Biol Sci. 18:4824–4836. 2022. View Article : Google Scholar : PubMed/NCBI

38 

Zhang M, Wang Z, Wu Y, Chen M, Li J and Liu G: Hypoxia-induced factor-1α promotes radioresistance of esophageal cancer cells by transcriptionally activating LINC01116 and suppressing miR-3612 under hypoxia. J Biochem Mol Toxicol. 38:e235512024. View Article : Google Scholar : PubMed/NCBI

39 

Zhang S, Zhong J, Guo D, Zhang S, Huang G, Chen Y, Xu C, Chen W, Zhang Q, Zhao C, et al: MIAT shuttled by tumor-secreted exosomes promotes paclitaxel resistance in esophageal cancer cells by activating the TAF1/SREBF1 axis. J Biochem Mol Toxicol. 37:e233802023. View Article : Google Scholar : PubMed/NCBI

40 

Cao Z, Zhu J, Wang Z, Peng Y and Zeng L: Comprehensive pan-cancer analysis reveals ENC1 as a promising prognostic biomarker for tumor microenvironment and therapeutic responses. Sci Rep. 14:253312024. View Article : Google Scholar : PubMed/NCBI

41 

Lu JT, Yan ZY, Xu TX, Zhao F, Liu L, Li F and Guo W: Reciprocal regulation of LINC00941 and SOX2 promotes progression of esophageal squamous cell carcinoma. Cell Death Dis. 14:722023. View Article : Google Scholar : PubMed/NCBI

42 

Li Q, Zhang Z, Jiang H, Hou J, Chai Y, Nan H, Li F and Wang L: DLEU1 promotes cell survival by preventing DYNLL1 degradation in esophageal squamous cell carcinoma. J Transl Med. 20:2452022. View Article : Google Scholar : PubMed/NCBI

43 

Huang J, Li J, Li Y, Lu Z, Che Y, Mao S, Lei Y, Zang R, Zheng S, Liu C, et al: Interferon-inducible lncRNA IRF1-AS represses esophageal squamous cell carcinoma by promoting interferon response. Cancer Lett. 459:86–99. 2019. View Article : Google Scholar : PubMed/NCBI

44 

Qian FC, Zhou LW, Li YY, Yu ZM, Li LD, Wang YZ, Xu MC, Wang QY and Li CQ: SEanalysis 2.0: A comprehensive Super-enhancer regulatory network analysis tool for human and mouse. Nucleic Acids Res. 51:W520–W527. 2023. View Article : Google Scholar : PubMed/NCBI

45 

Saville L, Wu L, Habtewold J, Cheng Y, Gollen B, Mitchell L, Stuart-Edwards M, Haight T, Mohajerani M and Zovoilis A: NERD-seq: A novel approach of Nanopore direct RNA sequencing that expands representation of Non-coding RNAs. Genome Biol. 25:2332024. View Article : Google Scholar : PubMed/NCBI

46 

Liu Z, Gao L, Cheng L, Lv G, Sun B, Wang G and Tang Q: The roles of N6-methyladenosine and its target regulatory noncoding RNAs in tumors: Classification, mechanisms, and potential therapeutic implications. Exp Mol Med. 55:487–501. 2023. View Article : Google Scholar : PubMed/NCBI

47 

Plath K, Fang J, Mlynarczyk-Evans SK, Cao R, Worringer KA, Wang H, de la Cruz CC, Otte AP, Panning B and Zhang Y: Role of histone H3 lysine 27 methylation in X inactivation. Science. 300:131–135. 2003. View Article : Google Scholar : PubMed/NCBI

48 

Guttman M, Amit I, Garber M, French C, Lin MF, Feldser D, Huarte M, Zuk O, Carey BW, Cassady JP, et al: Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature. 458:223–227. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E and Chang HY: Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell. 129:1311–1323. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Rinn JL and Chang HY: Genome regulation by long noncoding RNAs. Annu Rev Biochem. 81:145–166. 2012. View Article : Google Scholar : PubMed/NCBI

51 

Huarte M: The emerging role of lncRNAs in cancer. Nat Med. 21:1253–1261. 2015. View Article : Google Scholar : PubMed/NCBI

52 

Schmitt AM and Chang HY: Long Noncoding RNAs in cancer pathways. Cancer Cell. 29:452–463. 2016. View Article : Google Scholar : PubMed/NCBI

53 

Bhan A and Mandal SS: Long noncoding RNAs: Emerging stars in gene regulation, epigenetics and human disease. ChemMedChem. 9:1932–1956. 2014. View Article : Google Scholar : PubMed/NCBI

54 

Yates AD, Achuthan P, Akanni W, Allen J, Allen J, Alvarez-Jarreta J, Amode MR, Armean IM, Azov AG, Bennett R, et al: Ensembl 2020. Nucleic Acids Res. 48:D682–D688. 2020.PubMed/NCBI

55 

Mattick JS and Makunin IV: Non-coding RNA. Hum Mol Genet. 15:R17–R29. 2006. View Article : Google Scholar : PubMed/NCBI

56 

Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, et al: Antisense transcription in the mammalian transcriptome. Science. 309:1564–1566. 2005. View Article : Google Scholar : PubMed/NCBI

57 

Pelechano V and Steinmetz LM: Gene regulation by antisense transcription. Nat Rev Genet. 14:880–893. 2013. View Article : Google Scholar : PubMed/NCBI

58 

Ma L, Bajic VB and Zhang Z: On the classification of long non-coding RNAs. RNA Biol. 10:925–934. 2013. View Article : Google Scholar : PubMed/NCBI

59 

Quinn JJ and Chang HY: Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet. 17:47–62. 2016. View Article : Google Scholar : PubMed/NCBI

60 

Cheng S, Jia Y, Wu J, Li J and Cao Y: Helicobacter pylori infection induces gastric cancer cell malignancy by targeting HOXA-AS2/miR-509-3p/MMD2 axis. Genes Genomics. 46:647–657. 2024. View Article : Google Scholar : PubMed/NCBI

61 

Yan S, Teng L, Du J, Ji L, Xu P, Zhao W and Tao W: Long non-coding RNA DANCR aggravates breast cancer through the miR-34c/E2F1 feedback loop. Mol Med Rep. 29:932024. View Article : Google Scholar : PubMed/NCBI

62 

Wang C, Chen R, Zhu X, Zhang X and Lian N: Long noncoding RNA small nucleolar RNA host gene 5 facilitates neuropathic pain in spinal nerve injury by promoting SCN9A expression via CDK9. Hum Cell. 37:451–464. 2024. View Article : Google Scholar : PubMed/NCBI

63 

Geisler S and Coller J: RNA in unexpected places: Long non-coding RNA functions in diverse cellular contexts. Nat Rev Mol Cell Biol. 14:699–712. 2013. View Article : Google Scholar : PubMed/NCBI

64 

Gudenas BL and Wang L: Prediction of LncRNA subcellular localization with deep learning from sequence features. Sci Rep. 8:163852018. View Article : Google Scholar : PubMed/NCBI

65 

Gozzetti A and Le Beau MM: Fluorescence in situ hybridization: Uses and limitations. Semin Hematol. 37:320–333. 2000. View Article : Google Scholar : PubMed/NCBI

66 

Keene JD, Komisarow JM and Friedersdorf MB: RIP-Chip: The isolation and identification of mRNAs, microRNAs and protein components of ribonucleoprotein complexes from cell extracts. Nat Protoc. 1:302–307. 2006. View Article : Google Scholar : PubMed/NCBI

67 

Wang Z, Gerstein M and Snyder M: RNA-Seq: A revolutionary tool for transcriptomics. Nat Rev Genet. 10:57–63. 2009. View Article : Google Scholar : PubMed/NCBI

68 

Macosko EZ, Basu A, Satija R, Nemesh J, Shekhar K, Goldman M, Tirosh I, Bialas AR, Kamitaki N, Martersteck EM, et al: Highly parallel Genome-wide expression profiling of individual cells using nanoliter droplets. Cell. 161:1202–1214. 2015. View Article : Google Scholar : PubMed/NCBI

69 

Shaffer SM, Dunagin MC, Torborg SR, Torre EA, Emert B, Krepler C, Beqiri M, Sproesser K, Brafford PA, Xiao M, et al: Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance. Nature. 546:431–435. 2017. View Article : Google Scholar : PubMed/NCBI

70 

Hezroni H, Koppstein D, Schwartz MG, Avrutin A, Bartel DP and Ulitsky I: Principles of long noncoding RNA evolution derived from direct comparison of transcriptomes in 17 species. Cell Rep. 11:1110–1122. 2015. View Article : Google Scholar : PubMed/NCBI

71 

Necsulea A, Soumillon M, Warnefors M, Liechti A, Daish T, Zeller U, Baker JC, Grützner F and Kaessmann H: The evolution of lncRNA repertoires and expression patterns in tetrapods. Nature. 505:635–640. 2014. View Article : Google Scholar : PubMed/NCBI

72 

Pang KC, Frith MC and Mattick JS: Rapid evolution of noncoding RNAs: Lack of conservation does not mean lack of function. Trends Genet. 22:1–5. 2006. View Article : Google Scholar : PubMed/NCBI

73 

Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, et al: The transcriptional landscape of the mammalian genome. Science. 309:1559–1563. 2005. View Article : Google Scholar : PubMed/NCBI

74 

Derrien T, Johnson R, Bussotti G, Tanzer A, Djebali S, Tilgner H, Guernec G, Martin D, Merkel A, Knowles DG, et al: The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression. Genome Res. 22:1775–1789. 2012. View Article : Google Scholar : PubMed/NCBI

75 

Tong YS, Wang XW, Zhou XL, Liu ZH, Yang TX, Shi WH, Xie HW, Lv J, Wu QQ and Cao XF: Identification of the long non-coding RNA POU3F3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinoma. Mol Cancer. 14:32015. View Article : Google Scholar : PubMed/NCBI

76 

Wang W, He X, Zheng Z, Ma X, Hu X, Wu D and Wang M: Serum HOTAIR as a novel diagnostic biomarker for esophageal squamous cell carcinoma. Mol Cancer. 16:752017. View Article : Google Scholar : PubMed/NCBI

77 

Wang Y, Pang D and Zhang X: The function of lncRNA LINC00997 as a diagnostic marker in the progression of esophageal squamous cell carcinoma. Ann Clin Lab Sci. 53:230–237. 2023.PubMed/NCBI

78 

Xie K, Zheng C, Gu W, Jiang Z, Luo C, Luo J, Diao Y, Wang G, Cong Z, Yao X, et al: A RASSF8-AS1 based exosomal lncRNAs panel used for diagnostic and prognostic biomarkers for esophageal squamous cell carcinoma. Thorac Cancer. 13:3341–3352. 2022. View Article : Google Scholar : PubMed/NCBI

79 

Yan Y, Li S, Wang S, Rubegni P, Tognetti L, Zhang J and Yan L: Long noncoding RNA HAND2-AS1 inhibits cancer cell proliferation, migration, and invasion in esophagus squamous cell carcinoma by regulating microRNA-21. J Cell Biochem. 120:9564–9571. 2019. View Article : Google Scholar : PubMed/NCBI

80 

Zhihua Z, Weiwei W, Lihua N, Jianying Z and Jiang G: p53-induced long non-coding RNA PGM5-AS1 inhibits the progression of esophageal squamous cell carcinoma through regulating miR-466/PTEN axis. IUBMB Life. 71:1492–1502. 2019. View Article : Google Scholar : PubMed/NCBI

81 

Zhou M, Bao S, Gong T, Wang Q, Sun J, Li J, Lu M, Sun W, Su J, Chen H and Liu Z: The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamous cell carcinoma. Nat Commun. 14:37992023. View Article : Google Scholar : PubMed/NCBI

82 

Liu Y, Li T, Peng C, Mao Q, Shen B, Shi M, Lu H, Xiao T, Yang A and Cheng C: Knockdown of long noncoding RNA LINC00240 inhibits esophageal cancer progression by regulating miR-26a-5p. Contrast Media Mol Imaging. 2022:10716272022. View Article : Google Scholar : PubMed/NCBI

83 

Luo D, Huang Z, Lv H, Wang Y, Sun W and Sun X: Up-regulation of MicroRNA-21 indicates poor prognosis and promotes cell proliferation in esophageal squamous cell carcinoma via upregulation of lncRNA SNHG1. Cancer Manag Res. 12:1–14. 2020. View Article : Google Scholar : PubMed/NCBI

84 

Ma L, Yan W, Sun X and Chen P: Chen, long noncoding RNA VPS9D1-AS1 promotes esophageal squamous cell carcinoma progression via the Wnt/β-catenin signaling pathway. J Cancer. 12:6894–6904. 2021. View Article : Google Scholar : PubMed/NCBI

85 

Sun K, Zhao X, Wan J, Yang L, Chu J, Dong S, Yin H, Ming L and He F: The diagnostic value of long non-coding RNA MIR31HG and its role in esophageal squamous cell carcinoma. Life Sci. 202:124–130. 2018. View Article : Google Scholar : PubMed/NCBI

86 

Shi T, Gao G and Cao Y: Long noncoding RNAs as novel biomarkers have a promising future in cancer diagnostics. Dis Markers. 2016:90851952016. View Article : Google Scholar : PubMed/NCBI

87 

Shi K, Liu T, Fu H, Li W and Zheng X: Zheng, Genome-wide analysis of lncRNA stability in human. PLoS Comput Biol. 17:e10089182021. View Article : Google Scholar : PubMed/NCBI

88 

Sole C, Arnaiz E, Manterola L, Otaegui D and Lawrie CH: The circulating transcriptome as a source of cancer liquid biopsy biomarkers. Semin Cancer Biol. 58:100–108. 2019. View Article : Google Scholar : PubMed/NCBI

89 

Lo YM: Circulating nucleic acids in plasma and serum: An overview. Ann N Y Acad Sci. 945:1–7. 2001. View Article : Google Scholar : PubMed/NCBI

90 

Qi P, Zhou XY and Du X: Circulating long non-coding RNAs in cancer: Current status and future perspectives. Mol Cancer. 15:392016. View Article : Google Scholar : PubMed/NCBI

91 

Xie H, Ma H and Zhou D: Plasma HULC as a promising novel biomarker for the detection of hepatocellular carcinoma. Biomed Res Int. 2013:1361062013. View Article : Google Scholar : PubMed/NCBI

92 

Revenfeld AL, Bæk R, Nielsen MH, Stensballe A, Varming K and Jørgensen M: Diagnostic and prognostic potential of extracellular vesicles in peripheral blood. Clin Ther. 36:830–846. 2014. View Article : Google Scholar : PubMed/NCBI

93 

Mathieu M, Martin-Jaular L, Lavieu G and Théry C: Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat Cell Biol. 21:9–17. 2019. View Article : Google Scholar : PubMed/NCBI

94 

Benes V and Castoldi M: Expression profiling of microRNA using real-time quantitative PCR, how to use it and what is available. Methods. 50:244–249. 2010. View Article : Google Scholar : PubMed/NCBI

95 

Hu HB, Jie HY and Zheng XX: Three circulating LncRNA predict early progress of esophageal squamous cell carcinoma. Cell Physiol Biochem. 40:117–125. 2016. View Article : Google Scholar : PubMed/NCBI

96 

Hu L, Xie K, Zheng C, Qiu B, Jiang Z, Luo C, Diao Y, Luo J, Yao X and Shen Y: Exosomal MALAT1 promotes the proliferation of esophageal squamous cell carcinoma through glyoxalase 1-dependent methylglyoxal removal. Noncoding RNA Res. 9:330–340. 2024. View Article : Google Scholar : PubMed/NCBI

97 

Rong H, Chen B, Ma K, Wei X, Peng J and Zhu J: Downregulation of lncRNA LINC-PINT participates in the recurrence of esophageal squamous cell carcinoma possibly by interacting miRNA-21. Cancer Biother Radiopharm. 36:273–279. 2021.PubMed/NCBI

98 

Sharma U, Barwal TS, Khandelwal A, Rana MK, Rana APS, Singh K and Jain A: Circulating long Non-Coding RNAs LINC00324 and LOC100507053 as potential liquid biopsy markers for esophageal squamous cell carcinoma: A pilot study. Front Oncol. 12:8239532022. View Article : Google Scholar : PubMed/NCBI

99 

Uttam V, Rana MK, Sharma U, Singh K and Jain A: Circulating long non-coding RNA EWSAT1 acts as a liquid biopsy marker for esophageal squamous cell carcinoma: A pilot study. Noncoding RNA Res. 9:1–11. 2024. View Article : Google Scholar : PubMed/NCBI

100 

Zhang J, Hu SL, Qiao CH, Ye JF, Li M, Ma HM, Wang JH, Xin SY and Yuan ZL: LncRNA-NEF inhibits proliferation, migration and invasion of esophageal squamous-cell carcinoma cells by inactivating wnt/β-catenin pathway. Eur Rev Med Pharmacol Sci. 22:6824–6831. 2018.PubMed/NCBI

101 

Jiao Z, Yu A, Rong W, He X, Zen K, Shi M and Wang T: Five-lncRNA signature in plasma exosomes serves as diagnostic biomarker for esophageal squamous cell carcinoma. Aging (Albany NY). 12:15002–15010. 2020. View Article : Google Scholar : PubMed/NCBI

102 

Yan S, Du L, Jiang X, Duan W, Li J, Xie Y, Zhan Y, Zhang S, Wang L, Li S and Wang C: Evaluation of serum exosomal lncRNAs as diagnostic and prognostic biomarkers for esophageal squamous cell carcinoma. Cancer Manag Res. 12:9753–9763. 2020. View Article : Google Scholar : PubMed/NCBI

103 

Yao W, Liu J, Hou Z, Jia X, Yang D, Feng M, Wu S and Wei L: Recombinant human protein TCFL5-activated NRSN2-AS1 promotes esophageal cancer progression via the microRNA-874-5p/RELT regulatory axis. Int J Biol Macromol. 277:1338142024. View Article : Google Scholar : PubMed/NCBI

104 

Luo Q, Kuang Y, Tao X, Zhu X, Zhao X, Lu G, Zhang W, Sun E and Chen B: Pan-cancer analysis of PCAT6 and its effect on oesophageal squamous cell carcinoma cell proliferation and migration. Med Oncol. 40:1252023. View Article : Google Scholar : PubMed/NCBI

105 

Huang T, You Q, Huang D, Zhang Y, He Z, Shen X, Li F, Shen Q, Onyebuchi IC, Wu C, et al: A positive feedback between PDIA3P1 and OCT4 promotes the cancer stem cell properties of esophageal squamous cell carcinoma. Cell Commun Signal. 22:602024. View Article : Google Scholar : PubMed/NCBI

106 

Zhang S, Jiang H, Xu Z, Jiang Y, She Y, Huang X, Feng S, Chen W, Chen S, Chen Y, et al: The resistance of esophageal cancer cells to paclitaxel can be reduced by the knockdown of long noncoding RNA DDX11-AS1 through TAF1/TOP2A inhibition. Am J Cancer Res. 9:2233–2248. 2019.PubMed/NCBI

107 

Liu H, Zhang J, Luo X, Zeng M and Xu L, Zhang Q, Liu H, Guo J and Xu L: Overexpression of the long noncoding RNA FOXD2-AS1 promotes cisplatin resistance in esophageal squamous cell carcinoma through the miR-195/Akt/mTOR axis. Oncol Res. 28:65–73. 2020. View Article : Google Scholar : PubMed/NCBI

108 

Shen GY, Zhang Y, Huang RZ, Huang ZY, Yang LY, Chen DZ and Yang SB: FOXP4-AS1 promotes CD8+ T cell exhaustion and esophageal cancer immune escape through USP10-stabilized PD-L1. Immunol Res. 72:766–775. 2024. View Article : Google Scholar : PubMed/NCBI

109 

Guo Y, Wang L, Yang H and Ding N: Knockdown long non-coding RNA HCP5 enhances the radiosensitivity of esophageal carcinoma by modulating AKT signaling activation. Bioengineered. 13:884–893. 2022. View Article : Google Scholar : PubMed/NCBI

110 

Lin K, Jiang H, Zhuang SS, Qin YS, Qiu GD, She YQ, Zheng JT, Chen C, Fang L and Zhang SY: Long noncoding RNA LINC00261 induces chemosensitization to 5-fluorouracil by mediating methylation-dependent repression of DPYD in human esophageal cancer. FASEB J. 33:1972–1988. 2019. View Article : Google Scholar : PubMed/NCBI

111 

Sun Y, Wang J, Pan S, Yang T, Sun X, Wang Y, Shi X, Zhao X, Guo J and Zhang X: LINC00657 played oncogenic roles in esophageal squamous cell carcinoma by targeting miR-615-3p and JunB. Biomed Pharmacother. 108:316–324. 2018. View Article : Google Scholar : PubMed/NCBI

112 

Liang F, Luo Q, Han H, Zhang J, Yang Y and Chen J: Long noncoding RNA LINC01088 inhibits esophageal squamous cell carcinoma progression by targeting the NPM1-HDM2-p53 axis. Acta Biochim Biophys Sin (Shanghai). 55:367–381. 2023. View Article : Google Scholar : PubMed/NCBI

113 

Wu K, Wang Z, Huang Y, Yao L, Kang N, Ge W, Zhang R and He W: LncRNA PTPRG-AS1 facilitates glycolysis and stemness properties of esophageal squamous cell carcinoma cells through miR-599/PDK1 axis. J Gastroenterol Hepatol. 37:507–517. 2022. View Article : Google Scholar : PubMed/NCBI

114 

Tan R, Liu J, Wang J, Zhang W, He M and Zhang Y: Long noncoding RNA SNHG6 silencing sensitized esophageal cancer cells to 5-FU via EZH2/STAT pathway. Sci Rep. 13:53632023. View Article : Google Scholar : PubMed/NCBI

115 

Wang P, Yang Z, Ye T, Shao F, Li J, Sun N and He J: lncTUG1/miR-144-3p affect the radiosensitivity of esophageal squamous cell carcinoma by competitively regulating c-MET. J Exp Clin Cancer Res. 39:72020. View Article : Google Scholar : PubMed/NCBI

116 

Shi W, Gao Z, Song J and Wang W: Silence of FOXD2-AS1 inhibited the proliferation and invasion of esophagus cells by regulating miR-145-5p/CDK6 axis. Histol Histopathol. 35:1013–1021. 2020.PubMed/NCBI

117 

Xu J, Ma J, Guan B, Li J, Wang Y and Hu S: LncRNA HCP5 promotes malignant cell behaviors in esophageal squamous cell carcinoma via the PI3K/AKT/mTOR signaling. Cell Cycle. 20:1374–1388. 2021. View Article : Google Scholar : PubMed/NCBI

118 

Xu J, Liu X, Liu X and Zhi Y: Long noncoding RNA KCNMB2-AS1 promotes the development of esophageal cancer by modulating the miR-3194-3p/PYGL axis. Bioengineered. 12:6687–6702. 2021. View Article : Google Scholar : PubMed/NCBI

119 

Zhang F, Fan L, Kang X, Wei H and Li L: High LINC00626 expression promotes esophagogastric junction adenocarcinoma metastasis: The mediating role of the JAK1/STAT3/KHSRP axis. Nan Fang Yi Ke Da Xue Xue Bao. 44:541–552. 2024.PubMed/NCBI

120 

Zhang W, Chen Q and Lei C: lncRNA MIAT promotes cell invasion and migration in esophageal cancer. Exp Ther Med. 19:3267–3274. 2020.PubMed/NCBI

121 

Chu J, Li H, Xing Y, Jia J, Sheng J, Yang L, Sun K, Qu Y, Zhang Y, Yin H, et al: LncRNA MNX1-AS1 promotes progression of esophageal squamous cell carcinoma by regulating miR-34a/SIRT1 axis. Biomed Pharmacother. 116:1090292019. View Article : Google Scholar : PubMed/NCBI

122 

Li Y, Li J, Luo M, Zhou C, Shi X, Yang W, Lu Z, Chen Z, Sun N and He J: Novel long noncoding RNA NMR promotes tumor progression via NSUN2 and BPTF in esophageal squamous cell carcinoma. Cancer Lett. 430:57–66. 2018. View Article : Google Scholar : PubMed/NCBI

123 

Zhang S, Liao W, Wu Q, Huang X, Pan Z, Chen W, Gu S, Huang Z, Wang Y, Tang X, et al: LINC00152 upregulates ZEB1 expression and enhances epithelial-mesenchymal transition and oxaliplatin resistance in esophageal cancer by interacting with EZH2. Cancer Cell Int. 20:5692020. View Article : Google Scholar : PubMed/NCBI

124 

Niu G, Zhuang H, Li B and Cao G: Long noncoding RNA linc-UBC1 promotes tumor invasion and metastasis by regulating EZH2 and repressing E-cadherin in esophageal squamous cell carcinoma. J BUON. 23:157–162. 2018.PubMed/NCBI

125 

Li MK, Liu LX, Zhang WY, Zhan HL, Chen RP, Feng JL and Wu LF: Long non-coding RNA MEG3 suppresses epithelial-to-mesenchymal transition by inhibiting the PSAT1-dependent GSK-3β/Snail signaling pathway in esophageal squamous cell carcinoma. Oncol Rep. 44:2130–2142. 2020.PubMed/NCBI

126 

Guo B, He M, Ma M, Tian Z, Jin J and Tian G: Long Non-coding RNA X-inactive specific transcript promotes esophageal squamous cell carcinoma progression via the MicroRNA 34a/Zinc finger E-box-Binding homeobox 1 pathway. Dig Dis Sci. 69:1169–1181. 2024. View Article : Google Scholar : PubMed/NCBI

127 

Xiao Y, Tang J, Yang D, Zhang B, Wu J, Wu Z, Liao Q, Wang H, Wang W and Su M: Long noncoding RNA LIPH-4 promotes esophageal squamous cell carcinoma progression by regulating the miR-216b/IGF2BP2 axis. Biomark Res. 10:602022. View Article : Google Scholar : PubMed/NCBI

128 

Li D, Li D, Meng L, Liu J, Huang C and Sun H: LncRNA NLIPMT inhibits tumorigenesis in esophageal Squamous-cell carcinomas by regulating miR-320/Survivin axis. Cancer Manag Res. 12:12603–12612. 2020. View Article : Google Scholar : PubMed/NCBI

129 

Zhang Y, Li R, Ding X, He M and Zhang R: Long noncoding RNA SNHG6 promotes oesophageal squamous cell carcinoma by downregulating the miR-101-3p/EZH2 pathway. J Biochem Mol Toxicol. 36:e229592022. View Article : Google Scholar : PubMed/NCBI

130 

Hu D, Ma A, Lu H, Gao Z, Yu Y, Fan J, Liu S, Wang Y and Zhang M: LINC00963 promotes cisplatin resistance in esophageal squamous cell carcinoma by interacting with miR-10a to Upregulate SKA1 expression. Appl Biochem Biotechnol. 196:7219–7232. 2024. View Article : Google Scholar : PubMed/NCBI

131 

Zhao F, Tian H, Wang Y, Zhang J, Liu F and Fu L: LINC01004-SPI1 axis-activated SIGLEC9 in tumor-associated macrophages induces radioresistance and the formation of immunosuppressive tumor microenvironment in esophageal squamous cell carcinoma. Cancer Immunol Immunother. 72:1835–1851. 2023. View Article : Google Scholar : PubMed/NCBI

132 

Liu G, Guo W, Chen G, Li W, Cui Y, Qin J and Peng J: Lnc-MCEI mediated the chemosensitivity of esophageal squamous cell carcinoma via miR-6759-5p to competitively regulate IGF2. Int J Biol Sci. 16:2938–2950. 2020. View Article : Google Scholar : PubMed/NCBI

133 

Zhu ZJ, Pang Y, Jin G, Zhang HY, Wang WH, Liu JW, Tuo GX, Wu P, Yang Y, Wang ZQ and Wang K: Hypoxia induces chemoresistance of esophageal cancer cells to cisplatin through regulating the lncRNA-EMS/miR-758-3p/WTAP axis. Aging (Albany NY). 13:17155–17176. 2021. View Article : Google Scholar : PubMed/NCBI

134 

Xu C, Guo Y, Liu H, Chen G, Yan Y and Liu T: TUG1 confers cisplatin resistance in esophageal squamous cell carcinoma by epigenetically suppressing PDCD4 expression via EZH2. Cell Biosci. 8:612018. View Article : Google Scholar : PubMed/NCBI

135 

Zhang H, Hua Y, Jiang Z, Yue J, Shi M, Zhen X, Zhang X, Yang L, Zhou R and Wu S: Cancer-associated Fibroblast-promoted LncRNA DNM3OS confers radioresistance by regulating DNA damage response in esophageal squamous cell carcinoma. Clin Cancer Res. 25:1989–2000. 2019. View Article : Google Scholar : PubMed/NCBI

136 

Wu J, Liu Y, Huang X, Cheng Y, Qian Z, Ni X, Chen S, Lin M and Luo J: LncRNA DGCR5 silencing enhances the Radio-sensitivity of human esophageal squamous cell carcinoma via negatively regulating the Warburg effect. Radiat Res. 199:264–272. 2023. View Article : Google Scholar : PubMed/NCBI

137 

Chen M, Liu P, Chen Y, Chen Z, Shen M, Liu X, Li X, Li A, Lin Y, Yang R, et al: Long noncoding RNA FAM201A mediates the radiosensitivity of esophageal squamous cell cancer by regulating ATM and mTOR expression via miR-101. Front Genet. 9:6112018. View Article : Google Scholar : PubMed/NCBI

138 

Lin J, Liu Z, Liao S, Li E, Wu X and Zeng W: Elevation of long non-coding RNA GAS5 and knockdown of microRNA-21 up-regulate RECK expression to enhance esophageal squamous cell carcinoma cell radio-sensitivity after radiotherapy. Genomics. 112:2173–2185. 2020. View Article : Google Scholar : PubMed/NCBI

139 

Hu M, Zhang Q, Tian XH, Wang JL, Niu YX and Li G: lncRNA CCAT1 is a biomarker for the proliferation and drug resistance of esophageal cancer via the miR-143/PLK1/BUBR1 axis. Mol Carcinog. 58:2207–2217. 2019. View Article : Google Scholar : PubMed/NCBI

140 

Nan Y, Luo Q, Wu X, Chang W, Zhao P, Liu S and Liu Z: HCP5 prevents ubiquitination-mediated UTP3 degradation to inhibit apoptosis by activating c-Myc transcriptional activity. Mol Ther. 31:552–568. 2023. View Article : Google Scholar : PubMed/NCBI

141 

Chen W, Zhang Y, Wang H, Pan T, Zhang Y and Li C: LINC00473/miR-374a-5p regulates esophageal squamous cell carcinoma via targeting SPIN1 to weaken the effect of radiotherapy. J Cell Biochem. 120:14562–14572. 2019. View Article : Google Scholar : PubMed/NCBI

142 

Liu WH, Qiao HY, Xu J, Wang WQ, Wu YL and Wu X: LINC00473 contributes to the radioresistance of esophageal squamous cell carcinoma by regulating microRNA-497-5p and cell division cycle 25A. Int J Mol Med. 46:571–582. 2020. View Article : Google Scholar : PubMed/NCBI

143 

Wang L, Wang X, Yan P, Liu Y and Jiang X: LINC00261 suppresses cisplatin resistance of esophageal squamous cell carcinoma through miR-545-3p/MT1M Axis. Front Cell Dev Biol. 9:6877882021. View Article : Google Scholar : PubMed/NCBI

144 

Li N, Zhao Z, Miao F, Cai S, Liu P, Yu Y and Wang B: Silencing of long non-coding RNA LINC01270 inhibits esophageal cancer progression and enhances chemosensitivity to 5-fluorouracil by mediating GSTP1methylation. Cancer Gene Ther. 28:471–485. 2021. View Article : Google Scholar : PubMed/NCBI

145 

Jia Y, Tian C, Wang H, Yu F, Lv W, Duan Y, Cheng Z, Wang X, Wang Y, Liu T, et al: Long non-coding RNA NORAD/miR-224-3p/MTDH axis contributes to CDDP resistance of esophageal squamous cell carcinoma by promoting nuclear accumulation of β-catenin. Mol Cancer. 20:1622021. View Article : Google Scholar : PubMed/NCBI

146 

Sun Y, Wang J, Ma Y, Li J, Sun X, Zhao X, Shi X, Hu Y, Qu F and Zhang X: Radiation induces NORAD expression to promote ESCC radiotherapy resistance via EEPD1/ATR/Chk1 signalling and by inhibiting pri-miR-199a1 processing and the exosomal transfer of miR-199a-5p. J Exp Clin Cancer Res. 40:3062021. View Article : Google Scholar : PubMed/NCBI

147 

Chen Z, Wang Q, Huang L, Xu G and Hu J: LncRNA PVT1 confers cisplatin resistance of esophageal cancer cells through modulating the miR-181a-5p-glutaminase (GLS) axis. Nutr Cancer. 75:1646–1657. 2023. View Article : Google Scholar : PubMed/NCBI

148 

Wang L, Yu X, Zhang Z, Pang L, Xu J, Jiang J, Liang W, Chai Y, Hou J and Li F: Linc-ROR promotes esophageal squamous cell carcinoma progression through the derepression of SOX9. J Exp Clin Cancer Res. 36:1822017. View Article : Google Scholar : PubMed/NCBI

149 

Sahebi R, Malakootian M, Balalaee B, Shahryari A, Khoshnia M, Abbaszadegan MR, Moradi A and Javad Mowla S: Linc-ROR and its spliced variants 2 and 4 are significantly up-regulated in esophageal squamous cell carcinoma. Iran J Basic Med Sci. 19:1131–1135. 2016.PubMed/NCBI

150 

Chen Y, Tang J, Li L and Lu T: Effect of Linc-POU3F3 on radiotherapy resistance and cancer stem cell markers of esophageal cancer cells. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 46:583–590. 2021.(In English, Chinese). PubMed/NCBI

151 

Shahryari A, Rafiee MR, Fouani Y, Oliae NA, Samaei NM, Shafiee M, Semnani S, Vasei M and Mowla SJ: Two novel splice variants of SOX2OT, SOX2OT-S1, and SOX2OT-S2 are coupregulated with SOX2 and OCT4 in esophageal squamous cell carcinoma. Stem Cells. 32:126–134. 2014. View Article : Google Scholar : PubMed/NCBI

152 

Xue ST, Cao SQ, Ding JC, Li WJ, Hu GS, Zheng JC, Lin X, Chen C, Liu W and Zheng B: LncRNA LUESCC promotes esophageal squamous cell carcinoma by targeting the miR-6785-5p/NRSN2 axis. Cell Mol Life Sci. 81:1212024. View Article : Google Scholar : PubMed/NCBI

153 

Wang Y, Wang Y, Zhang J, Shi Z and Liu J: LncRNA NONHSAT227443.1 confers esophageal squamous cell carcinoma chemotherapy resistance by activating PI3K/AKT signaling via targeting MRTFB. Technol Cancer Res Treat. 23:153303382412743692024. View Article : Google Scholar : PubMed/NCBI

154 

Li HM, Yu YK, Liu Q, Wei XF, Zhang J, Zhang RX, Sun HB, Wang ZF, Xing WQ and Li Y: LncRNA SNHG1 regulates the progression of esophageal squamous cell cancer by the miR-204/HOXC8 axis. Onco Targets Ther. 13:757–767. 2020. View Article : Google Scholar : PubMed/NCBI

155 

Sun S, Huang C, Fan W, Wang Z, Li K, Liu X, Wang Z, Zhao T, Zhang G and Li X: FAM136A as a diagnostic biomarker in esophageal cancer: Insights into immune infiltration, m6A modification, alternative splicing, cuproptosis, and the ceRNA network. Adv Biol (Weinh). 8:e24001572024. View Article : Google Scholar : PubMed/NCBI

156 

Yang B, Ma H and Bian Y: LINC00261 inhibits esophageal cancer radioresistance by Down-regulating microRNA-552-3p and promoting DIRAS1. Cancer Manag Res. 13:8559–8573. 2021. View Article : Google Scholar : PubMed/NCBI

157 

Yang C, Shen S, Zheng X, Ye K, Ge H, Sun Y and Lu Y: Long non-coding RNA LINC00337 induces autophagy and chemoresistance to cisplatin in esophageal squamous cell carcinoma cells via upregulation of TPX2 by recruiting E2F4. FASEB J. 34:6055–6069. 2020. View Article : Google Scholar : PubMed/NCBI

158 

Kong N, Chi Y, Ma H and Luo D: LncRNA SNHG1 acts as a ceRNA for miR-216a-3p to regulate TMBIM6 expression in esophageal squamous cell carcinoma. J Cancer. 15:3128–3139. 2024. View Article : Google Scholar : PubMed/NCBI

159 

Li Z, Yan H, Wang B, Wang H, Chen A, Zhu T, Liu J, Yu G and Kang M: High methylation of the same promoter of lncRNA ZNF582-AS1/ZNF582 promotes malignant progression of esophageal cancer. Epigenomics. 16:733–752. 2024. View Article : Google Scholar : PubMed/NCBI

160 

Sharma A, Boise LH and Shanmugam M: Cancer metabolism and the evasion of apoptotic cell death. Cancers (Basel). 11:11442019. View Article : Google Scholar : PubMed/NCBI

161 

Neve B, Jonckheere N, Vincent A and Van Seuningen I: Epigenetic regulation by lncRNAs: An overview focused on UCA1 in colorectal cancer. Cancers (Basel). 10:4402018. View Article : Google Scholar : PubMed/NCBI

162 

Lou W, Ding B and Fu P: Pseudogene-derived lncRNAs and their miRNA sponging mechanism in human cancer. Front Cell Dev Biol. 8:852020. View Article : Google Scholar : PubMed/NCBI

163 

Statello L, Guo CJ, Chen LL and Huarte M: Gene regulation by long non-coding RNAs and its biological functions. Nat Rev Mol Cell Biol. 22:96–118. 2021. View Article : Google Scholar : PubMed/NCBI

164 

Nasrolahi A, Khojasteh Pour F, Mousavi Salehi A, Kempisty B, Hajizadeh M, Feghhi M, Azizidoost S and Farzaneh M: Potential roles of lncRNA MALAT1-miRNA interactions in ocular diseases. J Cell Commun Signal. 17:1203–1217. 2023. View Article : Google Scholar : PubMed/NCBI

165 

Sarropoulos I, Marin R, Cardoso-Moreira M and Kaessmann H: Developmental dynamics of lncRNAs across mammalian organs and species. Nature. 571:510–514. 2019. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lin Y, Lv Z, Xie H, Zhao W, Pu R, Zhang Z and Jin H: Functions and mechanisms of long non‑coding RNA in esophageal squamous cell carcinoma (Review). Oncol Lett 30: 418, 2025.
APA
Lin, Y., Lv, Z., Xie, H., Zhao, W., Pu, R., Zhang, Z., & Jin, H. (2025). Functions and mechanisms of long non‑coding RNA in esophageal squamous cell carcinoma (Review). Oncology Letters, 30, 418. https://doi.org/10.3892/ol.2025.15164
MLA
Lin, Y., Lv, Z., Xie, H., Zhao, W., Pu, R., Zhang, Z., Jin, H."Functions and mechanisms of long non‑coding RNA in esophageal squamous cell carcinoma (Review)". Oncology Letters 30.3 (2025): 418.
Chicago
Lin, Y., Lv, Z., Xie, H., Zhao, W., Pu, R., Zhang, Z., Jin, H."Functions and mechanisms of long non‑coding RNA in esophageal squamous cell carcinoma (Review)". Oncology Letters 30, no. 3 (2025): 418. https://doi.org/10.3892/ol.2025.15164
Copy and paste a formatted citation
x
Spandidos Publications style
Lin Y, Lv Z, Xie H, Zhao W, Pu R, Zhang Z and Jin H: Functions and mechanisms of long non‑coding RNA in esophageal squamous cell carcinoma (Review). Oncol Lett 30: 418, 2025.
APA
Lin, Y., Lv, Z., Xie, H., Zhao, W., Pu, R., Zhang, Z., & Jin, H. (2025). Functions and mechanisms of long non‑coding RNA in esophageal squamous cell carcinoma (Review). Oncology Letters, 30, 418. https://doi.org/10.3892/ol.2025.15164
MLA
Lin, Y., Lv, Z., Xie, H., Zhao, W., Pu, R., Zhang, Z., Jin, H."Functions and mechanisms of long non‑coding RNA in esophageal squamous cell carcinoma (Review)". Oncology Letters 30.3 (2025): 418.
Chicago
Lin, Y., Lv, Z., Xie, H., Zhao, W., Pu, R., Zhang, Z., Jin, H."Functions and mechanisms of long non‑coding RNA in esophageal squamous cell carcinoma (Review)". Oncology Letters 30, no. 3 (2025): 418. https://doi.org/10.3892/ol.2025.15164
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team