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Review

Histone lactylation: A new frontier in laryngeal cancer research (Review)

  • Authors:
    • Qiaoling Tong
    • Chunsheng Huang
    • Qizhen Tong
    • Zhiyu Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Ningbo No. 2 Hospital, Ningbo, Zhejiang 315000, P.R. China, Department of Anesthesiology, Ningbo Medical Center Lihuili Hospital, Medical School of Ningbo University, Ningbo, Zhejiang 315000, P.R. China, Department of Operating Room, The Affiliated People's Hospital of Ningbo University, Ningbo, Zhejiang 315000, P.R. China, Glasgow International College, Anderson College, Glasgow G11 6NU, United Kingdom
  • Article Number: 421
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    Published online on: July 2, 2025
       https://doi.org/10.3892/ol.2025.15167
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Abstract

Laryngeal cancer is a common malignant tumor of the head and neck, and its occurrence and development are closely related to epigenetic modifications. Histone lactylation, a novel form of epigenetic modification, regulates gene expression and is involved in processes such as tumor metabolic reprogramming, shaping the tumor microenvironment, maintaining tumor stem cell characteristics and developing treatment resistance. The present review highlighted the molecular mechanisms and detection methods of histone lactylation and explores its potential role in laryngeal cancer, as it may serve as a valuable biomarker for diagnosis and prognosis. Furthermore, targeting the lactylation pathway may provide novel therapeutic strategies, with the potential to improve treatment outcomes for patients. Overall, understanding the role of histone lactylation in laryngeal cancer may potentially lead to innovative diagnostic and therapeutic approaches and improve the management of laryngeal cancer in the future.
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Copy and paste a formatted citation
Spandidos Publications style
Tong Q, Huang C, Tong Q and Zhang Z: Histone lactylation: A new frontier in laryngeal cancer research (Review). Oncol Lett 30: 421, 2025.
APA
Tong, Q., Huang, C., Tong, Q., & Zhang, Z. (2025). Histone lactylation: A new frontier in laryngeal cancer research (Review). Oncology Letters, 30, 421. https://doi.org/10.3892/ol.2025.15167
MLA
Tong, Q., Huang, C., Tong, Q., Zhang, Z."Histone lactylation: A new frontier in laryngeal cancer research (Review)". Oncology Letters 30.3 (2025): 421.
Chicago
Tong, Q., Huang, C., Tong, Q., Zhang, Z."Histone lactylation: A new frontier in laryngeal cancer research (Review)". Oncology Letters 30, no. 3 (2025): 421. https://doi.org/10.3892/ol.2025.15167
Copy and paste a formatted citation
x
Spandidos Publications style
Tong Q, Huang C, Tong Q and Zhang Z: Histone lactylation: A new frontier in laryngeal cancer research (Review). Oncol Lett 30: 421, 2025.
APA
Tong, Q., Huang, C., Tong, Q., & Zhang, Z. (2025). Histone lactylation: A new frontier in laryngeal cancer research (Review). Oncology Letters, 30, 421. https://doi.org/10.3892/ol.2025.15167
MLA
Tong, Q., Huang, C., Tong, Q., Zhang, Z."Histone lactylation: A new frontier in laryngeal cancer research (Review)". Oncology Letters 30.3 (2025): 421.
Chicago
Tong, Q., Huang, C., Tong, Q., Zhang, Z."Histone lactylation: A new frontier in laryngeal cancer research (Review)". Oncology Letters 30, no. 3 (2025): 421. https://doi.org/10.3892/ol.2025.15167
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