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Case Report Open Access

Bronchial granular cell tumor incidentally detected during preoperative evaluation of thyroid carcinoma: A case report

  • Authors:
    • Biao Wang
    • Guozhu Liu
    • Baolu Liu
    • Rushuai Hou
    • Cuiping Li
    • Mengjie Li
    • Jian Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Cangzhou Fifth Hospital (People's Hospital of Qingxian), Cangzhou, Hebei 062650, P.R. China, Department of Cardiothoracic Urology, Cangzhou Fifth Hospital (People's Hospital of Qingxian), Cangzhou, Hebei 062650, P.R. China, Department of Pathology, Cangzhou Fifth Hospital (People's Hospital of Qingxian), Cangzhou, Hebei 062650, P.R. China, Department of Cardiothoracic Surgery, General Hospital of Central Theater Command of The People's Liberation Army, Wuhan, Hebei 430070, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 425
    |
    Published online on: July 3, 2025
       https://doi.org/10.3892/ol.2025.15171
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Abstract

The present case report describes a rare granular cell tumor (GCT) found in the right lower lobe bronchus of a 36‑year‑old male patient. The tumor was incidentally discovered during preparation for thyroid cancer surgery. The patient had noticed a neck mass 3 months prior to admission, which led to an ultrasound‑guided bilateral thyroid mass perforated biopsy and pathological examination. The examination revealed thyroid papillary carcinoma. A chest computed tomography scan showed a mass measuring ~29x23 cm near the right lower lobe hilum. Bronchoscopy, histopathological examination and immunohistochemical staining confirmed the diagnosis of GCT. The patient underwent a successful right lower lobe resection and had a smooth postoperative recovery. Subsequently, 1 month later, the patient underwent thyroid cancer surgery without any complications. The patient was regularly monitored and no specific discomfort was reported during the 18‑month follow‑up.
View Figures

Figure 1

CT and bronchoscopy images. (A)
Thyroid CT examination revealed a mass in the right lobe and a
low-density lesion in the left lobe. (B) Chest enhanced CT scan in
the lung window demonstrated a mass near the right lower lobar
hilum measuring ~2.9×2.3 cm. (C) Chest CT scan in the mediastinal
window displayed lesion attenuation ranging from 23 to 65 HU, with
an average of 42 HU. (D) Arterial phase of the chest CT enhancement
revealed lesion attenuation ranging from 16 to 53 HU, with an
average of 36 HU. (E) Venous phase of the chest CT enhancement
showed lesion attenuation ranging from 35 to 82 HU, with an average
of 59 HU. (F) Intraoperative bronchoscopy revealed a smooth mucosa
in the basal segment of the right lower lobe, with extraluminal
compressive narrowing. CT, computed tomography; HU, Hounsfield
unit.

Figure 2

Pathological and immunohistochemical
diagnosis. (A) Pathological examination at low magnification showed
tumor-like lesions with intact capsules (H&E; magnification,
×200). (B) High magnification view (H&E; magnification, ×400)
showed enlarged tumor cells, predominantly round or polygonal, with
small centrally located nuclei, rich cytoplasm and visible
red-staining granules. No atypia, mitotic figures or necrosis are
observed, presenting a nested and sheet-like arrangement,
consistent with granular cell tumor. Immunohistochemical staining
reveals positive staining for (C) CD68 and (D) S-100
(magnification, ×100). H&E, hematoxylin and eosin.
View References

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Copy and paste a formatted citation
Spandidos Publications style
Wang B, Liu G, Liu B, Hou R, Li C, Li M and Zhu J: Bronchial granular cell tumor incidentally detected during preoperative evaluation of thyroid carcinoma: A case report. Oncol Lett 30: 425, 2025.
APA
Wang, B., Liu, G., Liu, B., Hou, R., Li, C., Li, M., & Zhu, J. (2025). Bronchial granular cell tumor incidentally detected during preoperative evaluation of thyroid carcinoma: A case report. Oncology Letters, 30, 425. https://doi.org/10.3892/ol.2025.15171
MLA
Wang, B., Liu, G., Liu, B., Hou, R., Li, C., Li, M., Zhu, J."Bronchial granular cell tumor incidentally detected during preoperative evaluation of thyroid carcinoma: A case report". Oncology Letters 30.3 (2025): 425.
Chicago
Wang, B., Liu, G., Liu, B., Hou, R., Li, C., Li, M., Zhu, J."Bronchial granular cell tumor incidentally detected during preoperative evaluation of thyroid carcinoma: A case report". Oncology Letters 30, no. 3 (2025): 425. https://doi.org/10.3892/ol.2025.15171
Copy and paste a formatted citation
x
Spandidos Publications style
Wang B, Liu G, Liu B, Hou R, Li C, Li M and Zhu J: Bronchial granular cell tumor incidentally detected during preoperative evaluation of thyroid carcinoma: A case report. Oncol Lett 30: 425, 2025.
APA
Wang, B., Liu, G., Liu, B., Hou, R., Li, C., Li, M., & Zhu, J. (2025). Bronchial granular cell tumor incidentally detected during preoperative evaluation of thyroid carcinoma: A case report. Oncology Letters, 30, 425. https://doi.org/10.3892/ol.2025.15171
MLA
Wang, B., Liu, G., Liu, B., Hou, R., Li, C., Li, M., Zhu, J."Bronchial granular cell tumor incidentally detected during preoperative evaluation of thyroid carcinoma: A case report". Oncology Letters 30.3 (2025): 425.
Chicago
Wang, B., Liu, G., Liu, B., Hou, R., Li, C., Li, M., Zhu, J."Bronchial granular cell tumor incidentally detected during preoperative evaluation of thyroid carcinoma: A case report". Oncology Letters 30, no. 3 (2025): 425. https://doi.org/10.3892/ol.2025.15171
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