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Association of recurrence with patient and tumor factors in gastrointestinal stromal tumors of small intestine: A single‑institutional retrospective study

  • Authors:
    • Yuri Nishioka
    • Yasunori Matsumoto
    • Gaku Ohira
    • Koichi Hayano
    • Toru Tochigi
    • Tetsuro Maruyama
    • Yoshihiro Kurata
    • Ryota Otsuka
    • Koichiro Okada
    • Atsushi Hirata
    • Michihiro Maruyama
    • Hisahiro Matsubara
  • View Affiliations / Copyright

    Affiliations: Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba 260‑8670, Japan
    Copyright: © Nishioka et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 447
    |
    Published online on: July 17, 2025
       https://doi.org/10.3892/ol.2025.15193
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Abstract

Gastrointestinal stromal tumors (GISTs) are relatively rare, with 35% of GISTs occurring in the small intestine. The recurrence rate of small intestinal GISTs is higher than that of gastric GISTs. The present study aimed to identify the factors involved in the recurrence of small intestinal GISTs using data obtained from patients treated at Chiba University Graduate School of Medicine (Chuo, Japan). Overall, 27 lesions in 26 patients who underwent radical resection for small intestinal GISTs at Chiba University Hospital between January 2002 and December 2021 were retrospectively analyzed to determine the association between clinicopathological factors and recurrence. Recurrence occurred in 9 out of the 26 patients. A univariate nominal logistic analysis revealed that jejunal lesions, tumor size ≥60 mm, maximum standardized uptake value ≥8.4, mitotic count ≥4/50 high power field, Ki‑67 index ≥10%, neutrophil‑to‑lymphocyte ratio (NLR) ≥3.7, platelet‑to‑lymphocyte ratio ≥227 and Onodera's prognostic nutritional index ≤51 were significantly associated with postoperative recurrence. The NLR was moderately correlated with tumor size and Ki‑67 index. This study has revealed that patient and tumor factors are associated with the recurrence of small intestinal GISTs. Elucidating the fundamental mechanisms linking inflammatory and nutritional indicators to tumor recurrence may provide novel insights into the progression and treatment strategies required for small intestinal GISTs.
View Figures

Figure 1

Scatter plot matrix and correlation
coefficients for clinicopathological factors in patients with small
intestinal GIST. Strong correlations were observed between tumor
size and SUVmax (R=0.79; P<0.0001) and between mitotic counts
and Ki-67 index (R=0.74; P<0.0001). The patient factors showed
moderate to strong correlations with each other. Regarding the
relationship between tumor factors and patient factors, the NLR
showed a moderate correlation with tumor size (R=0.65; P<0.001)
and Ki-67 index (R=0.46; P=0.021), whereas the PLR and OPNI were
weakly correlated with tumor factors (R ranging from 0.10 to 0.29
for PLR, and −0.38 to −0.28 for OPNI). NLR,
neutrophil-to-lymphocyte ratio; GIST, gastrointestinal stromal
tumors; SUVmax, maximum standardized uptake value; PLR,
platelet-to-lymphocyte ratio; OPNI, Onodera's prognostic
nutritional index.
View References

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Copy and paste a formatted citation
Spandidos Publications style
Nishioka Y, Matsumoto Y, Ohira G, Hayano K, Tochigi T, Maruyama T, Kurata Y, Otsuka R, Okada K, Hirata A, Hirata A, et al: Association of recurrence with patient and tumor factors in gastrointestinal stromal tumors of small intestine: A single‑institutional retrospective study. Oncol Lett 30: 447, 2025.
APA
Nishioka, Y., Matsumoto, Y., Ohira, G., Hayano, K., Tochigi, T., Maruyama, T. ... Matsubara, H. (2025). Association of recurrence with patient and tumor factors in gastrointestinal stromal tumors of small intestine: A single‑institutional retrospective study. Oncology Letters, 30, 447. https://doi.org/10.3892/ol.2025.15193
MLA
Nishioka, Y., Matsumoto, Y., Ohira, G., Hayano, K., Tochigi, T., Maruyama, T., Kurata, Y., Otsuka, R., Okada, K., Hirata, A., Maruyama, M., Matsubara, H."Association of recurrence with patient and tumor factors in gastrointestinal stromal tumors of small intestine: A single‑institutional retrospective study". Oncology Letters 30.3 (2025): 447.
Chicago
Nishioka, Y., Matsumoto, Y., Ohira, G., Hayano, K., Tochigi, T., Maruyama, T., Kurata, Y., Otsuka, R., Okada, K., Hirata, A., Maruyama, M., Matsubara, H."Association of recurrence with patient and tumor factors in gastrointestinal stromal tumors of small intestine: A single‑institutional retrospective study". Oncology Letters 30, no. 3 (2025): 447. https://doi.org/10.3892/ol.2025.15193
Copy and paste a formatted citation
x
Spandidos Publications style
Nishioka Y, Matsumoto Y, Ohira G, Hayano K, Tochigi T, Maruyama T, Kurata Y, Otsuka R, Okada K, Hirata A, Hirata A, et al: Association of recurrence with patient and tumor factors in gastrointestinal stromal tumors of small intestine: A single‑institutional retrospective study. Oncol Lett 30: 447, 2025.
APA
Nishioka, Y., Matsumoto, Y., Ohira, G., Hayano, K., Tochigi, T., Maruyama, T. ... Matsubara, H. (2025). Association of recurrence with patient and tumor factors in gastrointestinal stromal tumors of small intestine: A single‑institutional retrospective study. Oncology Letters, 30, 447. https://doi.org/10.3892/ol.2025.15193
MLA
Nishioka, Y., Matsumoto, Y., Ohira, G., Hayano, K., Tochigi, T., Maruyama, T., Kurata, Y., Otsuka, R., Okada, K., Hirata, A., Maruyama, M., Matsubara, H."Association of recurrence with patient and tumor factors in gastrointestinal stromal tumors of small intestine: A single‑institutional retrospective study". Oncology Letters 30.3 (2025): 447.
Chicago
Nishioka, Y., Matsumoto, Y., Ohira, G., Hayano, K., Tochigi, T., Maruyama, T., Kurata, Y., Otsuka, R., Okada, K., Hirata, A., Maruyama, M., Matsubara, H."Association of recurrence with patient and tumor factors in gastrointestinal stromal tumors of small intestine: A single‑institutional retrospective study". Oncology Letters 30, no. 3 (2025): 447. https://doi.org/10.3892/ol.2025.15193
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