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October-2025 Volume 30 Issue 4

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Case Report Open Access

Primary cutaneous follicular center lymphoma of the upper arm: A case report

  • Authors:
    • Xintong Yu
    • Yi Wang
    • Yan Cui
    • Xiaoli Cao
  • View Affiliations / Copyright

    Affiliations: Department of Medical Imaging, Shandong Second Medical University, Weifang, Shandong 261053, P.R. China, Department of Medical Imaging, Qingdao University, Qingdao, Shandong 266071, P.R. China, Department of Ultrasound, The Affiliated Yantai Yuhuanding Hospital of Qingdao University, Yantai, Shandong 264000, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 477
    |
    Published online on: August 11, 2025
       https://doi.org/10.3892/ol.2025.15223
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Abstract

Primary cutaneous follicle center lymphoma (PCFCL) is unique in its biological behavior and molecular features, and it is also relatively rare. The present study reports a case of PCFCL in a young male patient, aged 32 years, whose primary skin lesion was located in the left upper arm. A skin biopsy confirmed that the dermal tissue of the patient's skin was affected by PCFCL. The patient was treated with radiation therapy and the mass was significantly reduced, with a resultant good prognosis. This case of a young patient with PCFCL is reported in order to provide a reference for the diagnostic segment of this disease.
View Figures

Figure 1

(A) A skin nodule on the left upper
arm, measuring ~4×3 cm and purplish in color. (B) Two-dimensional
ultrasound imaging and (C) color Doppler flow imaging of the
patient's skin lesions. Two-dimensional ultrasound images of the
patient's (D) axillary and (E) inguinal lymph nodes. (F)
Histopathological examination (dermis) revealing partial
proliferation of large, heterogeneous lymphoid cells arranged in
sheets, with nuclear atypia (hematoxylin and eosin; ×50
magnification).

Figure 2

Skin biopsy IHC results: Bcl-6(+),
Bcl-2(some weak +), CD10(+), CD20(+), MUM1(−), Ki-67(hotspot area
60% +) and c-MYC(30% weak +). Using in situ hybridization,
the sample was determined to be negative for EBV-EBER. All images
are ×100 magnification. IHC, immunohistochemistry; EBV-EBER,
Epstein-Barr virus-encoded small RNA.
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Copy and paste a formatted citation
Spandidos Publications style
Yu X, Wang Y, Cui Y and Cao X: Primary cutaneous follicular center lymphoma of the upper arm: A case report. Oncol Lett 30: 477, 2025.
APA
Yu, X., Wang, Y., Cui, Y., & Cao, X. (2025). Primary cutaneous follicular center lymphoma of the upper arm: A case report. Oncology Letters, 30, 477. https://doi.org/10.3892/ol.2025.15223
MLA
Yu, X., Wang, Y., Cui, Y., Cao, X."Primary cutaneous follicular center lymphoma of the upper arm: A case report". Oncology Letters 30.4 (2025): 477.
Chicago
Yu, X., Wang, Y., Cui, Y., Cao, X."Primary cutaneous follicular center lymphoma of the upper arm: A case report". Oncology Letters 30, no. 4 (2025): 477. https://doi.org/10.3892/ol.2025.15223
Copy and paste a formatted citation
x
Spandidos Publications style
Yu X, Wang Y, Cui Y and Cao X: Primary cutaneous follicular center lymphoma of the upper arm: A case report. Oncol Lett 30: 477, 2025.
APA
Yu, X., Wang, Y., Cui, Y., & Cao, X. (2025). Primary cutaneous follicular center lymphoma of the upper arm: A case report. Oncology Letters, 30, 477. https://doi.org/10.3892/ol.2025.15223
MLA
Yu, X., Wang, Y., Cui, Y., Cao, X."Primary cutaneous follicular center lymphoma of the upper arm: A case report". Oncology Letters 30.4 (2025): 477.
Chicago
Yu, X., Wang, Y., Cui, Y., Cao, X."Primary cutaneous follicular center lymphoma of the upper arm: A case report". Oncology Letters 30, no. 4 (2025): 477. https://doi.org/10.3892/ol.2025.15223
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