[Expression of Concern] Apelin‑13 induces autophagy in hepatoma HepG2 cells through ERK1/2 signaling pathway‑dependent upregulation of Beclin1

Huang,Qiulin; Liu,Xuan; Cao,Chao; Lei,Junyue; Han,Dong; Chen,Guodong; Yu,Jia; Chen,Linxi; Lv,Deguan; Li,Zhongyu

doi:10.3892/ol.2025.15236

November-2025 Volume 30 Issue 5

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November-2025 Volume 30 Issue 5

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Expression of Concern Open Access

[Expression of Concern] Apelin‑13 induces autophagy in hepatoma HepG2 cells through ERK1/2 signaling pathway‑dependent upregulation of Beclin1

Authors:
- Qiulin Huang
- Xuan Liu
- Chao Cao
- Junyue Lei
- Dong Han
- Guodong Chen
- Jia Yu
- Linxi Chen
- Deguan Lv
- Zhongyu Li
View Affiliations / Copyright

Affiliations: Department of General Surgery, First Affiliated Hospital of University of South Chin, Hengyang, Hunan 421001, P.R. China, Institute of Pharmacy and Pharmacology, School of Medicine, University of South China, Hengyang, Hunan 421001, P.R. China, Department of Microbiology, School of Medicine, University of South China, Hengyang, Hunan 421001, P.R. China

Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Article Number: 490
|
Published online on: August 20, 2025

https://doi.org/10.3892/ol.2025.15236
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Abstract

Following the publication of this paper, it was drawn to the Editor’s attention by a concerned reader that the GAPDH control blots looked unexpectedly similar in Figs. 2C and 3E, in which different experimental conditions were reported, suggesting that an error may have been made in the compilation of the data in one of these figures. The authors were contacted by the Editorial Office to offer an explanation for this apparent anomaly in the presentation of the data in this paper; however, up to this time, no response from them has been forthcoming. Owing to the fact that the Editorial Office has been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of this potential problem while the Editorial Office continues to investigate this matter further. [Oncology Letters 11: 1051‑1056, 2016; DOI: 10.3892/ol.2015.3991]

Oncol Lett 11: [Related article:] 1051–1056, 2016; DOI: 10.3892/ol.2015.3991

Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the GAPDH control blots looked unexpectedly similar in Figs. 2C and 3E, in which different experimental conditions were reported, suggesting that an error may have been made in the compilation of the data in one of these figures.

The authors were contacted by the Editorial Office to offer an explanation for this apparent anomaly in the presentation of the data in this paper; however, up to this time, no response from them has been forthcoming. Owing to the fact that the Editorial Office has been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of this potential problem while the Editorial Office continues to investigate this matter further.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

[Expression of Concern] Apelin‑13 induces autophagy in hepatoma HepG2 cells through ERK1/2 signaling pathway‑dependent upregulation of Beclin1

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Abstract

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