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Case Report Open Access

Rare hepatic metastasis in classical adenoid cystic carcinoma of the breast: A case report

  • Authors:
    • Xiaohui Huang
    • Yangjing Ou
    • Lin Tang
    • Wei Zhou
    • Taoli Wang
    • Miduo Tan
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan 412000, P.R. China, Department of Infectious Diseases, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan 412000, P.R. China, Department of Anesthesiology, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan 412000, P.R. China, Department of Pathology, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan 412000, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 495
    |
    Published online on: August 25, 2025
       https://doi.org/10.3892/ol.2025.15241
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Abstract

Adenoid cystic carcinoma of the breast (ACCB) is a rare and distinct form of triple‑negative breast cancer, accounting for only 0.06‑0.1% of all breast cancers. ACCB is characterized by a favorable prognosis and can be divided into three subtypes: Classical, solid and high‑grade transformation. The classical type is the most common and has the least aggressive biological behavior, with rare occurrences of metastasis. By contrast, patients with the solid and high‑grade transformation types are more likely to experience local recurrence and distant metastasis. The present report describes a rare case of hepatic metastasis in classical ACCB, and discusses its treatment and follow‑up. Additionally, the current advancements in the management of ACCB are reviewed to provide insights for further understanding and clinical guidance.
View Figures

Figure 1

Histopathological features of the
breast lesion and liver metastasis. (A) Hematoxylin and eosin
staining shows classic cribriform architecture composed of
dual-layered epithelial and myoepithelial cells, with outer
basaloid cells surrounding pseudolumina filled with eosinophilic
basement membrane-like material (original magnification, ×200). (B)
CD117-positive (magnification, ×200). (C) p63-positive
(magnification, ×200). (D) Hematoxylin and eosin staining reveals a
small number of cord-like epithelial cell nests with relatively
uniform size, arranged in glandular and nested patterns (original
magnification, ×100). (E) CD117-positive (magnification, ×100). (F)
p63-positive (magnification, ×100). (G) Progesterone
receptor-weakly positive (~1%; magnification, ×400). (H) Estrogen
receptor-negative (magnification, ×400). (I) Human epidermal growth
factor receptor 2-negative (magnification, ×400).

Figure 2

Abdominal CT imaging of the liver. (A)
March 2024: Multiple low-density hepatic lesions detected, with
certain lesions demonstrating poorly defined borders and internal
low-density non-enhancing necrotic areas. (B) May 2024: After two
cycles of salvage adjuvant chemotherapy, the treatment response was
evaluated as partial remission. (C) July 2024: After five cycles of
salvage adjuvant chemotherapy, partial remission was maintained.
(D) October 2024: Following six completed cycles of adjuvant
chemotherapy and no additional treatment, the response remained
partial remission.
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Copy and paste a formatted citation
Spandidos Publications style
Huang X, Ou Y, Tang L, Zhou W, Wang T and Tan M: Rare hepatic metastasis in classical adenoid cystic carcinoma of the breast: A case report. Oncol Lett 30: 495, 2025.
APA
Huang, X., Ou, Y., Tang, L., Zhou, W., Wang, T., & Tan, M. (2025). Rare hepatic metastasis in classical adenoid cystic carcinoma of the breast: A case report. Oncology Letters, 30, 495. https://doi.org/10.3892/ol.2025.15241
MLA
Huang, X., Ou, Y., Tang, L., Zhou, W., Wang, T., Tan, M."Rare hepatic metastasis in classical adenoid cystic carcinoma of the breast: A case report". Oncology Letters 30.5 (2025): 495.
Chicago
Huang, X., Ou, Y., Tang, L., Zhou, W., Wang, T., Tan, M."Rare hepatic metastasis in classical adenoid cystic carcinoma of the breast: A case report". Oncology Letters 30, no. 5 (2025): 495. https://doi.org/10.3892/ol.2025.15241
Copy and paste a formatted citation
x
Spandidos Publications style
Huang X, Ou Y, Tang L, Zhou W, Wang T and Tan M: Rare hepatic metastasis in classical adenoid cystic carcinoma of the breast: A case report. Oncol Lett 30: 495, 2025.
APA
Huang, X., Ou, Y., Tang, L., Zhou, W., Wang, T., & Tan, M. (2025). Rare hepatic metastasis in classical adenoid cystic carcinoma of the breast: A case report. Oncology Letters, 30, 495. https://doi.org/10.3892/ol.2025.15241
MLA
Huang, X., Ou, Y., Tang, L., Zhou, W., Wang, T., Tan, M."Rare hepatic metastasis in classical adenoid cystic carcinoma of the breast: A case report". Oncology Letters 30.5 (2025): 495.
Chicago
Huang, X., Ou, Y., Tang, L., Zhou, W., Wang, T., Tan, M."Rare hepatic metastasis in classical adenoid cystic carcinoma of the breast: A case report". Oncology Letters 30, no. 5 (2025): 495. https://doi.org/10.3892/ol.2025.15241
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