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Dynamic whole‑body positron emission tomography/computed tomography for predicting treatment response to chemoradiotherapy in patients with esophageal cancer

  • Authors:
    • Moe Iwata
    • Yoshihiro Kurata
    • Koichi Hayano
    • Gaku Ohira
    • Toru Tochigi
    • Atsushi Hirata
    • Ryota Miura
    • Masaya Uesato
    • Takeshi Toyozumi
    • Yasunori Matsumoto
    • Akira Nakano
    • Tadashi Shiraishi
    • Nobufumi Sekino
    • Takashi Imori
    • Hisahiro Matsubara
  • View Affiliations / Copyright

    Affiliations: Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba 260‑8677, Japan, Department of Radiology, Chiba University Graduate School of Medicine, Chiba 260‑8677, Japan
    Copyright: © Iwata et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 504
    |
    Published online on: September 1, 2025
       https://doi.org/10.3892/ol.2025.15250
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Abstract

Most positron emission tomography/computed tomography (PET/CT) studies are based on static whole‑body images; however, dynamic whole‑body PET/CT (DW‑PET/CT) enables quantification of tissue glucose metabolism dynamics. The aim of the present study was to investigate whether DW‑PET/CT can predict treatment response in patients with esophageal squamous cell carcinoma (ESCC) treated with chemoradiotherapy (CRT). A total of 56 patients with ESCC who underwent pretreatment DW‑PET/CT were evaluated. DW‑PET/CT parameters of the main tumor, including the Patlak slope (PS, absolute rate of tracer consumption) and Patlak intercept (PI, degree of tracer perfusion in the tumor), were calculated using four DW‑PET/CT image series acquired every 5 min starting 60 min after injection of 18F‑fluorodeoxyglucose. The maximum standardized uptake value (SUVmax) of the tumor was also measured 60 min after tracer injection. The relationships of these PET‑derived parameters with treatment response were analyzed using area under the receiver operating characteristic curve (AUC) analyses. The treatment responder group included 38 patients, whereas there were 18 non‑responders according to the Response Evaluation Criteria in Solid Tumors. Tumors of responders showed significantly higher SUVmax, PS and PI than those of non‑responders (P=0.04, 0.0012 and 0.0018, respectively). PS and PI demonstrated good performance in predicting treatment response with AUC values of 0.71 and 0.76, respectively, whereas the SUVmax showed a poor performance with an AUC value of 0.67. The tumor contraction rate during CRT was significantly and positively correlated with PS and PI (R=0.60, P=0.0061 and R=0.54, P=0.0265, respectively). In conclusion, DW‑PET/CT may enable pretreatment prediction of the CRT treatment response in patients with ESCC.
View Figures

Figure 1

An example of a VOI that was
generated semi-automatically. (A) Axial, (B) coronal and (C)
sagittal slices. VOI, volume of interest.

Figure 2

Relationship between SCC-associated
antigen and PS. SCC, squamous cell carcinoma; PS, Patlak slope.

Figure 3

Relationship between treatment
response, and SUVmax, PS or PI. AUC, area under the receiver
operating characteristic curve; PI, Patlak intercept; PS, Patlak
slope; SUVmax, maximum standardized uptake value.

Figure 4

Correlation between the tumor
contraction rate and PS or PI. PI, Patlak intercept; PS, Patlak
slope.
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Copy and paste a formatted citation
Spandidos Publications style
Iwata M, Kurata Y, Hayano K, Ohira G, Tochigi T, Hirata A, Miura R, Uesato M, Toyozumi T, Matsumoto Y, Matsumoto Y, et al: Dynamic whole‑body positron emission tomography/computed tomography for predicting treatment response to chemoradiotherapy in patients with esophageal cancer. Oncol Lett 30: 504, 2025.
APA
Iwata, M., Kurata, Y., Hayano, K., Ohira, G., Tochigi, T., Hirata, A. ... Matsubara, H. (2025). Dynamic whole‑body positron emission tomography/computed tomography for predicting treatment response to chemoradiotherapy in patients with esophageal cancer. Oncology Letters, 30, 504. https://doi.org/10.3892/ol.2025.15250
MLA
Iwata, M., Kurata, Y., Hayano, K., Ohira, G., Tochigi, T., Hirata, A., Miura, R., Uesato, M., Toyozumi, T., Matsumoto, Y., Nakano, A., Shiraishi, T., Sekino, N., Imori, T., Matsubara, H."Dynamic whole‑body positron emission tomography/computed tomography for predicting treatment response to chemoradiotherapy in patients with esophageal cancer". Oncology Letters 30.5 (2025): 504.
Chicago
Iwata, M., Kurata, Y., Hayano, K., Ohira, G., Tochigi, T., Hirata, A., Miura, R., Uesato, M., Toyozumi, T., Matsumoto, Y., Nakano, A., Shiraishi, T., Sekino, N., Imori, T., Matsubara, H."Dynamic whole‑body positron emission tomography/computed tomography for predicting treatment response to chemoradiotherapy in patients with esophageal cancer". Oncology Letters 30, no. 5 (2025): 504. https://doi.org/10.3892/ol.2025.15250
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Spandidos Publications style
Iwata M, Kurata Y, Hayano K, Ohira G, Tochigi T, Hirata A, Miura R, Uesato M, Toyozumi T, Matsumoto Y, Matsumoto Y, et al: Dynamic whole‑body positron emission tomography/computed tomography for predicting treatment response to chemoradiotherapy in patients with esophageal cancer. Oncol Lett 30: 504, 2025.
APA
Iwata, M., Kurata, Y., Hayano, K., Ohira, G., Tochigi, T., Hirata, A. ... Matsubara, H. (2025). Dynamic whole‑body positron emission tomography/computed tomography for predicting treatment response to chemoradiotherapy in patients with esophageal cancer. Oncology Letters, 30, 504. https://doi.org/10.3892/ol.2025.15250
MLA
Iwata, M., Kurata, Y., Hayano, K., Ohira, G., Tochigi, T., Hirata, A., Miura, R., Uesato, M., Toyozumi, T., Matsumoto, Y., Nakano, A., Shiraishi, T., Sekino, N., Imori, T., Matsubara, H."Dynamic whole‑body positron emission tomography/computed tomography for predicting treatment response to chemoradiotherapy in patients with esophageal cancer". Oncology Letters 30.5 (2025): 504.
Chicago
Iwata, M., Kurata, Y., Hayano, K., Ohira, G., Tochigi, T., Hirata, A., Miura, R., Uesato, M., Toyozumi, T., Matsumoto, Y., Nakano, A., Shiraishi, T., Sekino, N., Imori, T., Matsubara, H."Dynamic whole‑body positron emission tomography/computed tomography for predicting treatment response to chemoradiotherapy in patients with esophageal cancer". Oncology Letters 30, no. 5 (2025): 504. https://doi.org/10.3892/ol.2025.15250
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