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Risks of haematological malignancies in patients treated for solid tumours associated with the use of pegylated granulocyte colony‑stimulating factors: A single centre study since 2005

  • Authors:
    • Samuel Vokurka
    • Luboš Mastný
    • Vojtěch Kliment
    • Jana Kulhánková
    • Jana Dreslerová
    • Terezie Šamanová
    • Jindřich Fínek
  • View Affiliations / Copyright

    Affiliations: Department of Oncology and Radiotherapeutics, Faculty of Medicine of Charles University in Pilsen, University Hospital in Pilsen, Charles University, 32300 Pilsen, Czech Republic
    Copyright: © Vokurka et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 513
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    Published online on: September 5, 2025
       https://doi.org/10.3892/ol.2025.15259
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Abstract

The use of pegylated granulocyte colony‑stimulating factors (PGCSFs), specifically pegfilgrastim and lipegfilgrastim, has been widely adopted to reduce the incidence of febrile neutropenia in patients undergoing chemotherapy. However, concerns regarding the long‑term safety of PGCSFs, particularly the risk of secondary haematological malignancies, remain. The present study aimed to evaluate the incidence of secondary haematological malignancies in patients treated for solid tumours with PGCSFs at a single institution from 2005 to 2019. A retrospective analysis was conducted using an electronically managed database of 1,577 patients who received PGCSFs during chemotherapy for solid tumours. Patients with a history of any granulocyte or granulocyte‑macrophage colony‑stimulating factor administered prior to PGCSF were excluded. The incidence of secondary malignancies was assessed from the first application of PGCSF until the last patient contact, with a maximum follow‑up time until December 2023. Among the evaluated cohort of 1,577 patients with the median follow‑up time of 4.75 (0.0‑18.1) years, respectively, with 757 (36.4%) patients followed‑up for ≥5 years and 203 (18.1%) patients for ≥10 years; 7 (0.44%) patients were diagnosed with secondary haematological malignancies, including myelodysplastic syndrome in 2 patients, multiple myeloma in 3 patients and non‑Hodgkin lymphoma in 2 patients. The present study findings demonstrated that the long‑term use of PGCSFs in patients treated for solid tumours does not substantially increase the risk of secondary haematological malignancies, which supports their safety profile in clinical practice. However, a longer follow‑up is necessary to further evaluate the safety of PGCSFs, particularly for biosimilars.
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Copy and paste a formatted citation
Spandidos Publications style
Vokurka S, Mastný L, Kliment V, Kulhánková J, Dreslerová J, Šamanová T and Fínek J: Risks of haematological malignancies in patients treated for solid tumours associated with the use of pegylated granulocyte colony‑stimulating factors: A single centre study since 2005. Oncol Lett 30: 513, 2025.
APA
Vokurka, S., Mastný, L., Kliment, V., Kulhánková, J., Dreslerová, J., Šamanová, T., & Fínek, J. (2025). Risks of haematological malignancies in patients treated for solid tumours associated with the use of pegylated granulocyte colony‑stimulating factors: A single centre study since 2005. Oncology Letters, 30, 513. https://doi.org/10.3892/ol.2025.15259
MLA
Vokurka, S., Mastný, L., Kliment, V., Kulhánková, J., Dreslerová, J., Šamanová, T., Fínek, J."Risks of haematological malignancies in patients treated for solid tumours associated with the use of pegylated granulocyte colony‑stimulating factors: A single centre study since 2005". Oncology Letters 30.5 (2025): 513.
Chicago
Vokurka, S., Mastný, L., Kliment, V., Kulhánková, J., Dreslerová, J., Šamanová, T., Fínek, J."Risks of haematological malignancies in patients treated for solid tumours associated with the use of pegylated granulocyte colony‑stimulating factors: A single centre study since 2005". Oncology Letters 30, no. 5 (2025): 513. https://doi.org/10.3892/ol.2025.15259
Copy and paste a formatted citation
x
Spandidos Publications style
Vokurka S, Mastný L, Kliment V, Kulhánková J, Dreslerová J, Šamanová T and Fínek J: Risks of haematological malignancies in patients treated for solid tumours associated with the use of pegylated granulocyte colony‑stimulating factors: A single centre study since 2005. Oncol Lett 30: 513, 2025.
APA
Vokurka, S., Mastný, L., Kliment, V., Kulhánková, J., Dreslerová, J., Šamanová, T., & Fínek, J. (2025). Risks of haematological malignancies in patients treated for solid tumours associated with the use of pegylated granulocyte colony‑stimulating factors: A single centre study since 2005. Oncology Letters, 30, 513. https://doi.org/10.3892/ol.2025.15259
MLA
Vokurka, S., Mastný, L., Kliment, V., Kulhánková, J., Dreslerová, J., Šamanová, T., Fínek, J."Risks of haematological malignancies in patients treated for solid tumours associated with the use of pegylated granulocyte colony‑stimulating factors: A single centre study since 2005". Oncology Letters 30.5 (2025): 513.
Chicago
Vokurka, S., Mastný, L., Kliment, V., Kulhánková, J., Dreslerová, J., Šamanová, T., Fínek, J."Risks of haematological malignancies in patients treated for solid tumours associated with the use of pegylated granulocyte colony‑stimulating factors: A single centre study since 2005". Oncology Letters 30, no. 5 (2025): 513. https://doi.org/10.3892/ol.2025.15259
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