Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2025 Volume 30 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2025 Volume 30 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Exploring the clinical value of probiotics in the perioperative management of colorectal cancer: Meta‑analysis with trial sequential analysis

  • Authors:
    • Yang Zhang
    • Jiepin Hu
    • Qiong Xu
    • Youjie Yu
    • Haozhe Yan
    • Wei Shao
    • Feng Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, People's Hospital of Putuo District (Branch of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine), Zhoushan, Zhejiang 316100, P.R. China, Department of Oncology, People's Hospital of Putuo District (Branch of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine), Zhoushan, Zhejiang 316100, P.R. China, Department of Gastroenterology People's Hospital of Putuo District (Branch of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine), Zhoushan, Zhejiang 316100, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 515
    |
    Published online on: September 9, 2025
       https://doi.org/10.3892/ol.2025.15261
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Colorectal cancer (CRC) is the third most common malignant neoplasm, and there is currently no consensus on the clinical value of probiotics in perioperative CRC. A meta‑analysis combined with a trial sequential analysis (TSA) was performed to assess the efficacy and safety of probiotics in the adjuvant treatment of CRC to provide an evidence‑based recommendation for perioperative CRC. The present meta-analysis adhered to the Preferred Reporting Items for Systematic Reviews and Meta‑Analyses guidelines and the study protocol was registered with the International Prospective Register of Systematic Reviews (CRD42024510734). The meta‑analysis demonstrated that probiotics significantly reduced the incidence of postoperative infections in patients who underwent CRC surgery (risk ratio, 0.54; 95% CI, 0.45‑0.65; P<0.05). Although the sample size was insufficient for the required information size (n=2,897), TSA results demonstrated that cumulative Z values exceeded both the conventional and TSA cut‑offs, which indicated that this meta‑analysis barely extended the probability of false positives. Meanwhile, probiotics reduced the mean number of days of hospitalization for patients with CRC (mean difference, ‑1.23; 95% CI, ‑2.18 to ‑0.28; P<0.05). Notably, different genera of probiotics used contributed to different outcomes, with subgroup analyses indicating that Lactobacillus, Bifidobacterium, combined Lactobacillus with Bifidobacterium, and multiple combination strains significantly reduced the incidence of postoperative infections in CRC, with statistically significant differences, whereas Saccharomyces boulardii alone did not confer a potential benefit. Overall, probiotics appeared to be effective in reducing postoperative infectious complications and shortening the length of hospital stay.
View Figures

Figure 1

PRISMA flowchart detailing literature
search and screening strategy. PRISMA, Preferred Reporting Items
for Systematic Reviews and Meta-analyses; RCT, randomized
controlled trial; AACR, American Association for Cancer Research;
CBM, China Biology Medicine disc.

Figure 2

Meta-analysis of probiotics for the
incidence of postoperative infections.

Figure 3

Meta-analysis of probiotics for mean
hospitalization days.

Figure 4

Trial sequential analysis results for
probiotics for the incidence of postoperative infections. RIS,
required information size.
View References

1 

Dang HX, Krasnick BA, White BS, Grossman JG, Strand MS, Zhang J, Cabanski CR, Miller CA, Fulton RS, Goedegebuure SP, et al: The clonal evolution of metastatic colorectal cancer. Sci Adv. 6:eaay96912020. View Article : Google Scholar : PubMed/NCBI

2 

GBD 2021 Diseases, Injuries Collaborators, . Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: A systematic analysis for the Global Burden of Disease Study 2021. Lancet. 403:2133–2161. 2024.PubMed/NCBI

3 

Morgan E, Arnold M, Gini A, Lorenzoni V, Cabasag CJ, Laversanne M, Vignat J, Ferlay J, Murphy N and Bray F: Global burden of colorectal cancer in 2020 and 2040: Incidence and mortality estimates from GLOBOCAN. Gut. 72:338–344. 2023. View Article : Google Scholar : PubMed/NCBI

4 

Saffar KN, Larypoor M and Torbati MB: Analyzing of colorectal cancerrelated genes and microRNAs expression profiles in response to probiotics Lactobacillus acidophilus and Saccharomyces cerevisiae in colon cancer cell lines. Mol Biol Rep. 51:1222024. View Article : Google Scholar : PubMed/NCBI

5 

Türk S, Yılmaz A, Safari Baesmat A, Malkan UY, Ucar G and Türk C: The probiotic-induced disregulation of immune-related genes in colon cells and relation with colorectal cancer. Cell Mol Biol (Noisy-le-grand). 69:37–45. 2023. View Article : Google Scholar : PubMed/NCBI

6 

Siegel RL, Wagle NS, Cercek A, Smith RA and Jemal A: Colorectal cancer statistics, 2023. CA Cancer J Clin. 73:233–254. 2023.PubMed/NCBI

7 

Matsuda A, Maruyama H, Akagi S, Inoue T, Uemura K, Kobayashi M, Shiomi H, Watanabe M, Arai H, Kojima Y, et al: Do postoperative infectious complications really affect long-term survival in colorectal cancer surgery? A multicenter retrospective cohort study. Ann Gastroenterol Surg. 7:110–120. 2022. View Article : Google Scholar : PubMed/NCBI

8 

Guo J, Zhou B, Niu Y, Liu L and Yang L: Engineered probiotics introduced to improve intestinal microecology for the treatment of chronic diseases: present state and perspectives. J Diabetes Metab Disord. 22:1029–1038. 2023. View Article : Google Scholar : PubMed/NCBI

9 

Kim SH and Lim YJ: The role of microbiome in colorectal carcinogenesis and its clinical potential as a target for cancer treatment. Intest Res. 20:31–42. 2023. View Article : Google Scholar : PubMed/NCBI

10 

Wang X, Pan L, Wang F, Long F, Yang B and Tang D: Interventional effects of oral microecological agents on perioperative indicators of colorectal cancer: A meta-analysis. Front Oncol. 13:12291772023. View Article : Google Scholar : PubMed/NCBI

11 

Khorashadizadeh S, Abbasifar S, Yousefi M, Fayedeh F and Moodi Ghalibaf A: The role of microbiome and probiotics in chemo-radiotherapy-induced diarrhea: A narrative review of the current evidence. Cancer Rep (Hoboken). 7:e700292024.PubMed/NCBI

12 

He Z, Xie H, Xu H, Wu J, Zeng W, He Q, Jobin C, Jin S and Lan P: Chemotherapy-induced microbiota exacerbates the toxicity of chemotherapy through the suppression of interleukin-10 from macrophages. Gut Microbes. 16:23195112024. View Article : Google Scholar : PubMed/NCBI

13 

Imanbayev N, Iztleuov Y, Bekmukhambetov Y, Abdelazim IA, Donayeva A, Amanzholkyzy A, Aigul Z, Aigerim I and Aslan Y: Colorectal cancer and microbiota: Systematic review. Prz Gastroenterol. 16:380–396. 2024.PubMed/NCBI

14 

Sanders ME, Merenstein DJ, Reid G, Gibson GR and Rastall RA: Probiotics and prebiotics in intestinal health and disease: from biology to the clinic. Nat Rev Gastroenterol Hepatol. 16:605–616. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Azcárate-Peril MA, Sikes M and Bruno-Bárcena JM: The intestinal microbiota, gastrointestinal environment and colorectal cancer: A putative role for probiotics in prevention of colorectal cancer? Am J Physiol Gastrointest Liver Physiol. 301:G401–G424. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Paolillo R, Romano Carratelli C, Sorrentino S, Mazzola N and Rizzo A: Immunomodulatory effects of Lactobacillus plantarum on human colon cancer cells. Int Immunopharmacol. 9:1265–1271. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Yuan L, Zhang S, Li H, Yang F, Mushtaq N, Ullah S, Shi Y, An C and Xu J: The influence of gut microbiota dysbiosis to the efficacy of 5-Fluorouracil treatment on colorectal cancer. Biomed Pharmacother. 108:184–193. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Kumar A, Pramanik J, Batta K, Bamal P, Gaur M, Rustagi S, Prajapati BG and Bhattacharya S: Impact of metallic nanoparticles on gut microbiota modulation in colorectal cancer: A review. Cancer Innov. 3:e1502024. View Article : Google Scholar : PubMed/NCBI

19 

Zhao J, Liao Y, Wei C, Ma Y, Wang F, Chen Y, Zhao B, Ji H, Wang D and Tang D: Potential ability of probiotics in the prevention and treatment of colorectal cancer. Clin Med Insights Oncol. 17:117955492311882252023. View Article : Google Scholar : PubMed/NCBI

20 

Wu J, Ma X, Wang X, Zhu G, Wang H, Zhang Y and Li J: Efficacy and safety of compound kushen injection for advanced colorectal cancer: A systematic review and meta-analysis of randomized clinical trials with trial sequential analysis. Integr Cancer Ther. 23:153473542412584582024. View Article : Google Scholar : PubMed/NCBI

21 

Higgins JP, Savovic J and Page MJ: Chapter 8: Assessing risk of bias in a randomized trial. Cochrane Handbook for Systematic Reviews of Interventions version 6.2. Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al: Cochrane; 2021, Available from:. training.cochrane.org/handbook

22 

Weng H, Li S and Zeng XT: Application of the trial sequential analysis soft ware for meta-analysis. Chin J Evid-Based Med. 16:604–611. 2016.(In Chinese).

23 

Bajramagic S, Hodzic E, Mulabdic A, Holjan S, Smajlovic SV and Rovcanin A: Usage of probiotics and its clinical significance at surgically treated patients sufferig from colorectal carcinoma. Med Arch. 73:316–320. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Chen H, Xia Y, Shi C, Liang Y, Yang Y and Qin H: Effects of perioperative probiotics administration on patients with colorectal cancer. Chin J Clin Nutr. 22:82014.(In Chinese).

25 

Consoli ML, da Silva RS, Nicoli JR, Bruña-Romero O, da Silva RG, de Vasconcelos Generoso S and Correia MI: Randomized clinical trial: Impact of oral administration of saccharomyces boulardii on gene expression of intestinal cytokines in patients undergoing colon resection. JPEN J Parenter Enteral Nutr. 40:1114–1121. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Huang F, Li S, Chen W, Han Y, Yao Y, Yang L, Li Q, Xiao Q, Wei J, Liu Z, et al: Postoperative Probiotics administration attenuates gastrointestinal complications and gut microbiota dysbiosis caused by chemotherapy in colorectal cancer patients. Nutrients. 15:3562023. View Article : Google Scholar : PubMed/NCBI

27 

Kotzampassi K, Stavrou G, Damoraki G, Georgitsi M, Basdanis G, Tsaousi G and Giamarellos-Bourboulis EJ: A Four-Probiotics regimen reduces postoperative complications after colorectal surgery: A randomized, double-blind, placebo-controlled study. World J Surg. 39:2776–2783. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Liu Z, Qin H, Yang Z, Xia Y, Liu W, Yang J, Jiang Y, Zhang H, Yang Z, Wang Y and Zheng Q: Randomised clinical trial: The effects of perioperative probiotic treatment on barrier function and post-operative infectious complications in colorectal cancer surgery - a double-blind study. Aliment Pharmacol Ther. 33:50–63. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Liu ZH, Huang MJ, Zhang XW, Wang L, Huang NQ, Peng H, Lan P, Peng JS, Yang Z, Xia Y, et al: The effects of perioperative probiotic treatment on serum zonulin concentration and subsequent postoperative infectious complications after colorectal cancer surgery: A double-center and double-blind randomized clinical trial. Am J Clin Nutr. 97:117–126. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Liu Z, Li C, Huang M, Tong C, Zhang X, Wang L, Peng H, Lan P, Zhang P, Huang N, et al: Positive regulatory effects of perioperative probiotic treatment on postoperative liver complications after colorectal liver metastases surgery: A double-center and double-blind randomized clinical trial. BMC Gastroenterol. 15:342015. View Article : Google Scholar : PubMed/NCBI

31 

Mangell P, Thorlacius H, Syk I, Ahrné S, Molin G, Olsson C and Jeppsson B: Lactobacillus plantarum 299v does not reduce enteric bacteria or bacterial translocation in patients undergoing colon resection. Dig Dis Sci. 57:1915–1924. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Mizuta M, Endo I, Yamamoto S, Inokawa H, Kubo M, Udaka T, Sogabe O, Maeda H, Shirakawa K, Okazaki E, et al: Perioperative supplementation with bifidobacteria improves postoperative nutritional recovery, inflammatory response, and fecal microbiota in patients undergoing colorectal surgery: A prospective, randomized clinical trial. Biosci Microbiota Food Health. 35:77–87. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Park IJ, Lee JH, Kye BH, Oh HK, Cho YB, Kim YT, Kim JY, Sung NY, Kang SB, Seo JM, et al: Effects of probiotics on the symptoms and surgical ouTComes after anterior REsection of colon cancer (POSTCARE): A randomized, double-blind, placebo-controlled trial. J Clin Med. 9:21812020. View Article : Google Scholar : PubMed/NCBI

34 

Pellino G, Sciaudone G, Candilio G, Camerlingo A, Marcellinaro R, De Fatico S, Rocco F, Canonico S, Riegler G and Selvaggi F: Early postoperative administration of probiotics versus placebo in elderly patients undergoing elective colorectal surgery: A double-blind randomized controlled trial. BMC Surg. 13 (Suppl 2):S572013. View Article : Google Scholar : PubMed/NCBI

35 

Rodríguez-Padilla Á, Morales-Martín G, Pérez-Quintero R, Gómez-Salgado J, Balongo-García R and Ruiz-Frutos C: Postoperative ileus after stimulation with probiotics before ileostomy closure. Nutrients. 13:6262021. View Article : Google Scholar : PubMed/NCBI

36 

Sadahiro S, Suzuki T, Tanaka A, Okada K, Kamata H, Ozaki T and Koga Y: Comparison between oral antibiotics and probiotics as bowel preparation for elective colon cancer surgery to prevent infection: Prospective randomized trial. Surgery. 155:493–503. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Tan CK, Said S, Rajandram R, Wang Z, Roslani AC and Chin KF: Pre-surgical administration of microbial cell preparation in colorectal cancer patients: A randomized controlled trial. World J Surg. 40:1985–1992. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Xia Y, Yang Z, Chen HQ and Qin HL: Effect of bowel preparation with probiotics on intestinal barrier after surgery for colorectal cancer. Zhonghua Wei Chang Wai Ke Za Zhi. 13:528–531. 2010.(In Chinese). PubMed/NCBI

39 

Xu Q, Xu P, Cen Y and Li W: Effects of preoperative oral administration of glucose solution combined with postoperative probiotics on inflammation and intestinal barrier function in patients after colorectal cancer surgery. Oncol Lett. 18:694–698. 2019.PubMed/NCBI

40 

Yang Y, Xia Y, Chen H, Hong L, Feng J, Yang J, Yang Z, Shi C, Wu W, Gao R, et al: The effect of perioperative probiotics treatment for colorectal cancer: short-term outcomes of a randomized controlled trial. Oncotarget. 7:8432–8440. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Zaharuddin L, Mokhtar NM, Muhammad Nawawi KN and Raja Ali RA: A randomized double-blind placebo-controlled trial of probiotics in post-surgical colorectal cancer. BMC Gastroenterol. 19:1312019. View Article : Google Scholar : PubMed/NCBI

42 

Zhang W, Du P, Chen D, Cui L and Ying C: Effect of viable bifidobacterium supplementon theimmune statusand inflanunatory response inpatients undergoing resection for colorectal cancer. Chin J Gastrointest Surg. 13:40. 2010.

43 

Zhang JW, Du P, Gao J, Yang BR, Fang WJ and Ying CM: Preoperative probiotics decrease postoperative infectious complications of colorectal cancer. Am J Med Sci. 343:199–205. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Yu J, Nong C, Zhao J, Meng L and Song J: An integrative bioinformatic analysis of microbiome and transcriptome for predicting the risk of colon adenocarcinoma. Dis Markers. 2022:79940742022. View Article : Google Scholar : PubMed/NCBI

45 

Chang H, Lei L, Zhou Y, Ye F and Zhao G: Dietary flavonoids and the risk of colorectal cancer: An updated meta-analysis of epidemiological studies. Nutrients. 10:9502018. View Article : Google Scholar : PubMed/NCBI

46 

Al-Nemari R, Al-Senaidy A, Semlali A, Ismael M, Badjah-Hadj-Ahmed AY and Ben Bacha A: GC-MS profiling and assessment of antioxidant, antibacterial, and anticancer properties of extracts of Annona squamosa L. leaves. BMC Complement Med Ther. 20:2962020. View Article : Google Scholar : PubMed/NCBI

47 

Gopalakrishnan V, Spencer CN, Nezi L, Reuben A, Andrews MC, Karpinets TV, Prieto PA, Vicente D, Hoffman K, Wei SC, et al: Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science. 359:97–103. 2018. View Article : Google Scholar : PubMed/NCBI

48 

Wong CC and Yu J: Gut microbiota in colorectal cancer development and therapy. Nat Rev Clin Oncol. 20:429–452. 2023. View Article : Google Scholar : PubMed/NCBI

49 

Sun L, Zhu Z, Jia X, Ying X, Wang B, Wang P, Zhang S and Yu J: The difference of human gut microbiome in colorectal cancer with and without metastases. Front Oncol. 12:9827442022. View Article : Google Scholar : PubMed/NCBI

50 

Zhang W, An Y, Qin X, Wu X, Wang X, Hou H, Song X, Liu T, Wang B, Huang X and Cao H: Gut microbiota-derived metabolites in colorectal cancer: The bad and the challenges. Front Oncol. 11:7396482021. View Article : Google Scholar : PubMed/NCBI

51 

Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, et al: Expert consensus document. The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 11:506–514. 2014. View Article : Google Scholar : PubMed/NCBI

52 

Suez J, Zmora N, Segal E and Elinav E: The pros, cons, and many unknowns of probiotics. Nat Med. 25:716–729. 2019. View Article : Google Scholar : PubMed/NCBI

53 

Sonnenburg JL and Bäckhed F: Diet-microbiota interactions as moderators of human metabolism. Nature. 535:56–64. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Szajewska H and Kołodziej M: Systematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea. Aliment Pharmacol Ther. 42:793–801. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Szajewska H, Guarino A, Hojsak I, Indrio F, Kolacek S, Shamir R, Vandenplas Y and Weizman Z; European Society for Pediatric Gastroenterology, Hepatology, Nutrition, : Use of probiotics for management of acute gastroenteritis: A position paper by the ESPGHAN Working Group for Probiotics and Prebiotics. J Pediatr Gastroenterol Nutr. 58:531–539. 2014. View Article : Google Scholar : PubMed/NCBI

56 

Cani PD and Jordan BF: Gut microbiota-mediated inflammation in obesity: A link with gastrointestinal cancer. Nat Rev Gastroenterol Hepatol. 15:671–682. 2018. View Article : Google Scholar : PubMed/NCBI

57 

Huang HC, Cai BH, Suen CS, Lee HY, Hwang MJ, Liu FT and Kannagi R: BGN/TLR4/NF-B mediates epigenetic silencing of immunosuppressive siglec ligands in colon cancer cells. Cells. 9:3972020. View Article : Google Scholar : PubMed/NCBI

58 

Wu R, Shen Q, Li P and Shang N: Sturgeon chondroitin sulfate restores the balance of gut microbiota in colorectal cancer bearing mice. Int J Mol Sci. 23:37232022. View Article : Google Scholar : PubMed/NCBI

59 

Persson JE, Viana P, Persson M, Relvas JH and Danielski LG: Perioperative or postoperative probiotics reduce treatment-related complications in adult colorectal cancer patients undergoing surgery: A systematic review and meta-analysis. J Gastrointest Cancer. 55:740–748. 2024. View Article : Google Scholar : PubMed/NCBI

60 

An S, Kim K, Kim MH, Jung JH and Kim Y: Perioperative probiotics application for preventing postoperative complications in patients with colorectal cancer: A systematic review and meta-analysis. Medicina (Kaunas). 58:16442022. View Article : Google Scholar : PubMed/NCBI

61 

Araújo MM, Montalvão-Sousa TM, Teixeira PDC, Figueiredo ACMG and Botelho PB: The effect of probiotics on postsurgical complications in patients with colorectal cancer: A systematic review and meta-analysis. Nutr Rev. 81:493–510. 2023. View Article : Google Scholar : PubMed/NCBI

62 

Chen C, Wen T and Zhao Q: Probiotics used for postoperative infections in patients undergoing colorectal cancer surgery. Biomed Res Int. 2020:57347182020. View Article : Google Scholar : PubMed/NCBI

63 

Chen Y, Qi A, Teng D, Li S, Yan Y, Hu S and Du X: Probiotics and synbiotics for preventing postoperative infectious complications in colorectal cancer patients: A systematic review and meta-analysis. Tech Coloproctol. 26:425–436. 2022. View Article : Google Scholar : PubMed/NCBI

64 

Jaye K, Li CG and Bhuyan DJ: The complex interplay of gut microbiota with the five most common cancer types: From carcinogenesis to therapeutics to prognoses. Crit Rev Oncol Hematol. 165:1034292021. View Article : Google Scholar : PubMed/NCBI

65 

Iida N, Dzutsev A, Stewart CA, Smith L, Bouladoux N, Weingarten RA, Molina DA, Salcedo R, Back T, Cramer S, et al: Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science. 342:967–970. 2013. View Article : Google Scholar : PubMed/NCBI

66 

Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, et al: Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science. 359:91–97. 2018. View Article : Google Scholar : PubMed/NCBI

67 

Belkaid Y and Hand TW: Role of the microbiota in immunity and inflammation. Cell. 157:121–41. 2014. View Article : Google Scholar : PubMed/NCBI

68 

Zhang F, Aschenbrenner D, Yoo JY and Zuo T: The gut mycobiome in health, disease, and clinical applications in association with the gut bacterial microbiome assembly. Lancet Microbe. 3:e969–e983. 2022. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Hu J, Xu Q, Yu Y, Yan H, Shao W and Zhang F: Exploring the clinical value of probiotics in the perioperative management of colorectal cancer: Meta‑analysis with trial sequential analysis. Oncol Lett 30: 515, 2025.
APA
Zhang, Y., Hu, J., Xu, Q., Yu, Y., Yan, H., Shao, W., & Zhang, F. (2025). Exploring the clinical value of probiotics in the perioperative management of colorectal cancer: Meta‑analysis with trial sequential analysis. Oncology Letters, 30, 515. https://doi.org/10.3892/ol.2025.15261
MLA
Zhang, Y., Hu, J., Xu, Q., Yu, Y., Yan, H., Shao, W., Zhang, F."Exploring the clinical value of probiotics in the perioperative management of colorectal cancer: Meta‑analysis with trial sequential analysis". Oncology Letters 30.5 (2025): 515.
Chicago
Zhang, Y., Hu, J., Xu, Q., Yu, Y., Yan, H., Shao, W., Zhang, F."Exploring the clinical value of probiotics in the perioperative management of colorectal cancer: Meta‑analysis with trial sequential analysis". Oncology Letters 30, no. 5 (2025): 515. https://doi.org/10.3892/ol.2025.15261
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Hu J, Xu Q, Yu Y, Yan H, Shao W and Zhang F: Exploring the clinical value of probiotics in the perioperative management of colorectal cancer: Meta‑analysis with trial sequential analysis. Oncol Lett 30: 515, 2025.
APA
Zhang, Y., Hu, J., Xu, Q., Yu, Y., Yan, H., Shao, W., & Zhang, F. (2025). Exploring the clinical value of probiotics in the perioperative management of colorectal cancer: Meta‑analysis with trial sequential analysis. Oncology Letters, 30, 515. https://doi.org/10.3892/ol.2025.15261
MLA
Zhang, Y., Hu, J., Xu, Q., Yu, Y., Yan, H., Shao, W., Zhang, F."Exploring the clinical value of probiotics in the perioperative management of colorectal cancer: Meta‑analysis with trial sequential analysis". Oncology Letters 30.5 (2025): 515.
Chicago
Zhang, Y., Hu, J., Xu, Q., Yu, Y., Yan, H., Shao, W., Zhang, F."Exploring the clinical value of probiotics in the perioperative management of colorectal cancer: Meta‑analysis with trial sequential analysis". Oncology Letters 30, no. 5 (2025): 515. https://doi.org/10.3892/ol.2025.15261
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team