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Review Open Access

Tumor‑associated microbiota: Multi‑cancer landscape, mechanistic insights and clinical translation (Review)

  • Authors:
    • Jindi Yang
    • Yige Dong
    • Yi Chen
    • Hong Liang
    • Shengyu Rong
    • Zhe Liu
    • Qiulei Lang
  • View Affiliations / Copyright

    Affiliations: School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, P.R. China, Lc‑bio Technologies Hangzhou Co., Ltd., Hangzhou, Zhejiang 310018, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 527
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    Published online on: September 16, 2025
       https://doi.org/10.3892/ol.2025.15273
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Abstract

Intratumoral microbiota, a critical component of the tumor microenvironment, notably impacts tumor progression through various complex mechanisms such as metabolic regulation, immune system remodeling and genotoxicity. The present review focuses on eight prevalent solid tumors (breast, colorectal, lung, pancreatic, gastric, ovarian, prostate cancers and melanoma), detailing the intratumoral microbial compositional heterogeneity within these malignancies. The present review analyzes the heterogeneous carcinogenic mechanisms mediated by these microorganisms, including gene instability, immune microenvironment remodeling and metabolic intervention. The diagnostic value of microbial markers in liquid biopsy and in situ tissue detection is explored, and the potential for synergistic strategies combining microbial‑targeted therapy and immunotherapy is discussed. Finally, the review suggests future research directions, such as spatiotemporal dynamic analysis and organoid‑microorganism co‑culture, offering new insights for precise cancer treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Yang J, Dong Y, Chen Y, Liang H, Rong S, Liu Z and Lang Q: Tumor‑associated microbiota: Multi‑cancer landscape, mechanistic insights and clinical translation (Review). Oncol Lett 30: 527, 2025.
APA
Yang, J., Dong, Y., Chen, Y., Liang, H., Rong, S., Liu, Z., & Lang, Q. (2025). Tumor‑associated microbiota: Multi‑cancer landscape, mechanistic insights and clinical translation (Review). Oncology Letters, 30, 527. https://doi.org/10.3892/ol.2025.15273
MLA
Yang, J., Dong, Y., Chen, Y., Liang, H., Rong, S., Liu, Z., Lang, Q."Tumor‑associated microbiota: Multi‑cancer landscape, mechanistic insights and clinical translation (Review)". Oncology Letters 30.5 (2025): 527.
Chicago
Yang, J., Dong, Y., Chen, Y., Liang, H., Rong, S., Liu, Z., Lang, Q."Tumor‑associated microbiota: Multi‑cancer landscape, mechanistic insights and clinical translation (Review)". Oncology Letters 30, no. 5 (2025): 527. https://doi.org/10.3892/ol.2025.15273
Copy and paste a formatted citation
x
Spandidos Publications style
Yang J, Dong Y, Chen Y, Liang H, Rong S, Liu Z and Lang Q: Tumor‑associated microbiota: Multi‑cancer landscape, mechanistic insights and clinical translation (Review). Oncol Lett 30: 527, 2025.
APA
Yang, J., Dong, Y., Chen, Y., Liang, H., Rong, S., Liu, Z., & Lang, Q. (2025). Tumor‑associated microbiota: Multi‑cancer landscape, mechanistic insights and clinical translation (Review). Oncology Letters, 30, 527. https://doi.org/10.3892/ol.2025.15273
MLA
Yang, J., Dong, Y., Chen, Y., Liang, H., Rong, S., Liu, Z., Lang, Q."Tumor‑associated microbiota: Multi‑cancer landscape, mechanistic insights and clinical translation (Review)". Oncology Letters 30.5 (2025): 527.
Chicago
Yang, J., Dong, Y., Chen, Y., Liang, H., Rong, S., Liu, Z., Lang, Q."Tumor‑associated microbiota: Multi‑cancer landscape, mechanistic insights and clinical translation (Review)". Oncology Letters 30, no. 5 (2025): 527. https://doi.org/10.3892/ol.2025.15273
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