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Preoperative C‑reactive protein‑albumin‑lymphocyte index predicts survival outcomes in patients with stage I‑III colorectal cancer: A retrospective cohort study

  • Authors:
    • Jinquan Li
    • Xiaosheng Hu
    • Shanzhong Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, The Jingdezhen First People's Hospital, Jingdezhen, Jiangxi 333000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 535
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    Published online on: September 18, 2025
       https://doi.org/10.3892/ol.2025.15281
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Abstract

Colorectal cancer (CRC) is a major cause of cancer‑related mortality worldwide. The present study aimed to investigate the value of the preoperative C‑reactive protein‑albumin‑lymphocyte (CALLY) index in predicting recurrence‑free survival (RFS) and overall survival (OS) rates in patients with stage I‑III CRC. A retrospective analysis was conducted on 255 patients with stage I‑III CRC who underwent radical resection. The optimal cutoff value of the CALLY index was determined by receiver operating characteristic curve analysis, and patients were stratified into high‑ and low‑CALLY groups accordingly to assess its prognostic value for RFS and OS. The CALLY index had an area under the curve of 0.739 for predicting CRC prognosis. With a cutoff value of 6.790, patients in the high‑CALLY group exhibited significantly better RFS and OS rates compared with those in the low‑CALLY group. Multivariate Cox regression analysis confirmed CALLY as an independent prognostic factor. In conclusion, the preoperative CALLY index is an effective prognostic biomarker for predicting RFS and OS rates in patients with stage I‑III CRC, demonstrating potential clinical utility.
View Figures

Figure 1

Patient screening flowchart for
patients with stage I–III CRC undergoing radical resection. CRC,
colorectal cancer; CALLY, C-reactive
protein-albumin-lymphocyte.

Figure 2

Receiver operating characteristic
curve and AUC for the inflammatory markers. CALLY, C-reactive
protein-albumin-lymphocyte; AUC, area under the curve; CI,
confidence interval; TPR, true-positive rate (sensitivity); FPR,
false-positive rate (1-specificity).

Figure 3

Kaplan-Meier analysis of RFS in
patients with colorectal cancer stratified by CALLY index. CALLY,
C-reactive protein-albumin-lymphocyte; RFS, recurrence-free
survival.

Figure 4

Kaplan-Meier analysis of OS in
patients with colorectal cancer stratified by CALLY index. CALLY,
C-reactive protein-albumin-lymphocyte; OS, overall survival.
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Copy and paste a formatted citation
Spandidos Publications style
Li J, Hu X and Zhang S: Preoperative C‑reactive protein‑albumin‑lymphocyte index predicts survival outcomes in patients with stage I‑III colorectal cancer: A retrospective cohort study. Oncol Lett 30: 535, 2025.
APA
Li, J., Hu, X., & Zhang, S. (2025). Preoperative C‑reactive protein‑albumin‑lymphocyte index predicts survival outcomes in patients with stage I‑III colorectal cancer: A retrospective cohort study. Oncology Letters, 30, 535. https://doi.org/10.3892/ol.2025.15281
MLA
Li, J., Hu, X., Zhang, S."Preoperative C‑reactive protein‑albumin‑lymphocyte index predicts survival outcomes in patients with stage I‑III colorectal cancer: A retrospective cohort study". Oncology Letters 30.5 (2025): 535.
Chicago
Li, J., Hu, X., Zhang, S."Preoperative C‑reactive protein‑albumin‑lymphocyte index predicts survival outcomes in patients with stage I‑III colorectal cancer: A retrospective cohort study". Oncology Letters 30, no. 5 (2025): 535. https://doi.org/10.3892/ol.2025.15281
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Hu X and Zhang S: Preoperative C‑reactive protein‑albumin‑lymphocyte index predicts survival outcomes in patients with stage I‑III colorectal cancer: A retrospective cohort study. Oncol Lett 30: 535, 2025.
APA
Li, J., Hu, X., & Zhang, S. (2025). Preoperative C‑reactive protein‑albumin‑lymphocyte index predicts survival outcomes in patients with stage I‑III colorectal cancer: A retrospective cohort study. Oncology Letters, 30, 535. https://doi.org/10.3892/ol.2025.15281
MLA
Li, J., Hu, X., Zhang, S."Preoperative C‑reactive protein‑albumin‑lymphocyte index predicts survival outcomes in patients with stage I‑III colorectal cancer: A retrospective cohort study". Oncology Letters 30.5 (2025): 535.
Chicago
Li, J., Hu, X., Zhang, S."Preoperative C‑reactive protein‑albumin‑lymphocyte index predicts survival outcomes in patients with stage I‑III colorectal cancer: A retrospective cohort study". Oncology Letters 30, no. 5 (2025): 535. https://doi.org/10.3892/ol.2025.15281
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