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Case Report Open Access

Advanced dual primary male breast cancer and lung cancer: A case report and literature review

  • Authors:
    • Xiaoxiao Xing
    • Junyi Li
    • Yue Wang
    • Shiyun Zhang
    • Jun Li
    • Yun Wang
    • Dongpo Zhang
    • Daixiang Liao
  • View Affiliations / Copyright

    Affiliations: Department of Surgery and Pathology, Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100000, P.R. China
    Copyright: © Xing et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 2
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    Published online on: October 22, 2025
       https://doi.org/10.3892/ol.2025.15355
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Abstract

The current report presents a unique case of advanced male invasive breast cancer coexisting with synchronous primary lung adenocarcinoma, a rare clinical manifestation. The case contributes to the limited literature on male breast cancer and its association with multiple primary malignancies. The patient, a 59‑year‑old man, presented with a large ulcerative mass in the left breast (14x10 cm) and ground‑glass opacities with calcified nodules in the right lower lung lobe (14x14 mm). Imaging and pathology confirmed stage IIIB invasive ductal carcinoma of the breast [human epidermal growth factor receptor‑2‑positive, estrogen receptor‑positive (80%) and progesterone receptor‑positive (5%)] and minimally invasive lung adenocarcinoma. Treatment consisted of neoadjuvant chemotherapy (epirubicin + carboplatin + trastuzumab + pertuzumab), a modified radical mastectomy with latissimus dorsi flap reconstruction and a thoracoscopic lung wedge resection. The therapeutic approach resulted in partial remission of the breast cancer prior to surgery and a stable disease status in the lung, with no recurrence at the 1‑year follow‑up. This case underscores the importance of comprehensive, integrative strategies and long‑term follow‑up for managing rare, complex cancer cases.
View Figures

Figure 1

Breast tumor (pre-treatment
ulcerative breast mass) image captured in June 2023.

Figure 2

Pre-treatment CT images from June
2023. (A) CT scan showing enlarged axillary lymph nodes (yellow
arrow). (B) CT scan showing the breast tumor (yellow arrow). (C) CT
scan showing the lung tumor (yellow arrow). CT, computed
tomography.

Figure 3

Pre-treatment Ultrasonograms from
June 2023. (A) Ultrasonogram of the left breast mass (yellow
arrow). (B) Ultrasonogram of the left axillary lymph nodes (yellow
arrow).

Figure 4

Pathological sections diagnosing
invasive ductal carcinoma with labeled expression of specific
receptors. (A) Hematoxylin and eosin staining of the left breast
tissue showing invasive ductal carcinoma with Paget's-like spread
(magnification, ×400; scale bar, 100 µm). (B) Hematoxylin and eosin
staining of the intravascular tumor thrombus (magnification, ×400;
scale bar, 100 µm). (C) EnVision staining of progesterone receptor
(magnification, ×400; scale bar, 100 µm). (D) EnVision staining of
estrogen receptor (magnification, ×400; scale bar, 100 µm). (E)
EnVision staining of HER-2 (magnification, ×400; scale bar, 100
µm).

Figure 5

Post-chemotherapy images in October
2023 showing significant reduction of the breast tumor. (A)
Computed tomography scan showing the reduced breast tumor size
(yellow arrow). (B) Outward appearance of the breast tumor.

Figure 6

Surgical outcome after mastectomy
(October 2023).

Figure 7

Post-chemotherapy computed tomography
image (October 2023) showing stable lung nodule (yellow arrow).
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Copy and paste a formatted citation
Spandidos Publications style
Xing X, Li J, Wang Y, Zhang S, Li J, Wang Y, Zhang D and Liao D: Advanced dual primary male breast cancer and lung cancer: A case report and literature review. Oncol Lett 31: 2, 2026.
APA
Xing, X., Li, J., Wang, Y., Zhang, S., Li, J., Wang, Y. ... Liao, D. (2026). Advanced dual primary male breast cancer and lung cancer: A case report and literature review. Oncology Letters, 31, 2. https://doi.org/10.3892/ol.2025.15355
MLA
Xing, X., Li, J., Wang, Y., Zhang, S., Li, J., Wang, Y., Zhang, D., Liao, D."Advanced dual primary male breast cancer and lung cancer: A case report and literature review". Oncology Letters 31.1 (2026): 2.
Chicago
Xing, X., Li, J., Wang, Y., Zhang, S., Li, J., Wang, Y., Zhang, D., Liao, D."Advanced dual primary male breast cancer and lung cancer: A case report and literature review". Oncology Letters 31, no. 1 (2026): 2. https://doi.org/10.3892/ol.2025.15355
Copy and paste a formatted citation
x
Spandidos Publications style
Xing X, Li J, Wang Y, Zhang S, Li J, Wang Y, Zhang D and Liao D: Advanced dual primary male breast cancer and lung cancer: A case report and literature review. Oncol Lett 31: 2, 2026.
APA
Xing, X., Li, J., Wang, Y., Zhang, S., Li, J., Wang, Y. ... Liao, D. (2026). Advanced dual primary male breast cancer and lung cancer: A case report and literature review. Oncology Letters, 31, 2. https://doi.org/10.3892/ol.2025.15355
MLA
Xing, X., Li, J., Wang, Y., Zhang, S., Li, J., Wang, Y., Zhang, D., Liao, D."Advanced dual primary male breast cancer and lung cancer: A case report and literature review". Oncology Letters 31.1 (2026): 2.
Chicago
Xing, X., Li, J., Wang, Y., Zhang, S., Li, J., Wang, Y., Zhang, D., Liao, D."Advanced dual primary male breast cancer and lung cancer: A case report and literature review". Oncology Letters 31, no. 1 (2026): 2. https://doi.org/10.3892/ol.2025.15355
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