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Primary pulmonary angiosarcoma: A case study with genetic insights and potential therapeutic targets

  • Authors:
    • Yanling Zhu
    • Chunfang Guo
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Affiliated Banan Hospital of Chongqing Medical University, Chongqing 401320, P.R. China, Department of Pathology, Affiliated Banan Hospital of Chongqing Medical University, Chongqing 401320, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 15
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    Published online on: October 31, 2025
       https://doi.org/10.3892/ol.2025.15368
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Abstract

This case report describes a 71‑year‑old man who presented with hemoptysis, chest pain and shortness of breath. Computed tomography‑guided biopsy and immunohistochemical analysis revealed positivity for markers CD34, CD31 and vimentin, confirming the diagnosis of primary pulmonary vascular sarcoma. Genetic testing revealed actionable mutations in CD274 (programmed cell death ligand 1), kinase insert domain receptor, KIT and platelet‑derived growth factor receptor α, which may provide targeted treatment options. Unfortunately, the patient's condition rapidly worsened, and he died before therapy was initiated. This case emphasizes the difficulties in diagnosing pulmonary angiosarcoma and highlights potential molecular targets for therapy. Swift disease progression emphasizes the critical need for early detection and accurate diagnosis. Furthermore, the identified genetic alterations offer a basis for personalized targeted therapies, underscoring the importance of further research and clinical trials to enhance patient outcomes.
View Figures

Figure 1

Computed tomography of the chest. (A)
Lung window indicates a mass in the right lung (measuring ~147×113
mm). (B) Mediastinal window shows no evidence of calcification. The
affected area has been marked with arrows.

Figure 2

Patient's routine chest radiography
examination. The right lung and right lower part of the left lung
appear to be affected by the tumor. The affected areas have been
marked with arrows.

Figure 3

HE staining result. The cell nucleus
is deeply stained, has an abnormal shape, and there are numerous
instances of nuclear division (scale bars, 40 µm).

Figure 4

Immunohistochemical staining of lung
biopsy specimen. (A) Positive vimentin staining; (B) positive CD31
staining; (C) positive CD34 staining; (D) positive ETS-related gene
staining (scale bars, 40 µm).

Figure 5

Immunohistochemical staining of PD-L1
and VIII-RA. (A) Positive PD-L1 staining; (B) Positive VIII-RA
staining (scale bars, 40 µm). PD-L1, programmed death ligand 1;
VIII-RA, factor VIII-related antigen.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu Y and Guo C: Primary pulmonary angiosarcoma: A case study with genetic insights and potential therapeutic targets. Oncol Lett 31: 15, 2026.
APA
Zhu, Y., & Guo, C. (2026). Primary pulmonary angiosarcoma: A case study with genetic insights and potential therapeutic targets. Oncology Letters, 31, 15. https://doi.org/10.3892/ol.2025.15368
MLA
Zhu, Y., Guo, C."Primary pulmonary angiosarcoma: A case study with genetic insights and potential therapeutic targets". Oncology Letters 31.1 (2026): 15.
Chicago
Zhu, Y., Guo, C."Primary pulmonary angiosarcoma: A case study with genetic insights and potential therapeutic targets". Oncology Letters 31, no. 1 (2026): 15. https://doi.org/10.3892/ol.2025.15368
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Spandidos Publications style
Zhu Y and Guo C: Primary pulmonary angiosarcoma: A case study with genetic insights and potential therapeutic targets. Oncol Lett 31: 15, 2026.
APA
Zhu, Y., & Guo, C. (2026). Primary pulmonary angiosarcoma: A case study with genetic insights and potential therapeutic targets. Oncology Letters, 31, 15. https://doi.org/10.3892/ol.2025.15368
MLA
Zhu, Y., Guo, C."Primary pulmonary angiosarcoma: A case study with genetic insights and potential therapeutic targets". Oncology Letters 31.1 (2026): 15.
Chicago
Zhu, Y., Guo, C."Primary pulmonary angiosarcoma: A case study with genetic insights and potential therapeutic targets". Oncology Letters 31, no. 1 (2026): 15. https://doi.org/10.3892/ol.2025.15368
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