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Case Report Open Access

Photodynamic therapy with local‑targeted perfusion for recurrent tracheal adenoid cystic carcinoma achieving 12‑year survival: A case report

  • Authors:
    • Luoqi Yang
    • Lu Wang
    • Hongwu Wang
    • Heng Zou
  • View Affiliations / Copyright

    Affiliations: Respiratory Disease Center, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 18
    |
    Published online on: November 3, 2025
       https://doi.org/10.3892/ol.2025.15371
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Abstract

Adenoid cystic carcinoma (ACC) is a malignant tumor that originates from the ductal epithelium of the secretory glands and has a tendency for perineural invasion. Primary tracheal ACC is a clinically rare subtype, with an annual incidence rate of 0.04‑0.2%, accounting for <1% of all tracheal malignant tumors. Surgery and radiotherapy remain the standard treatments, but there are clinical challenges with the high recurrence rate. The present article reports the case of a patient who relapsed after partial tracheal resection and was considered inoperable. Bronchoscopy was used for airway assessment and interventional treatment, including submucosal injection and photodynamic therapy. After this intervention, the overall survival of the patient exceeded 12 years.
View Figures

Figure 1

Tracheal adenoid cystic carcinoma. (A)
CT scan of tracheal space-occupying lesion. (B and C) CT scan after
silicone stent implantation. (B) CT scan showing the upper edge of
the silicone stent after implantation. The silicone stent is
closely attached to the trachea, and the image displays the
condition of the upper part of the stent within the tracheal
structure, with the stent fitting well in this region. (C) CT scan
depicting the lower edge of the silicone stent post-implantation.
The silicone stent is fitted closely to the trachea, and the image
presents the condition of the lower part of the stent in relation
to the trachea and surrounding lung tissue, indicating the position
of the lower section of the stent. CT, computed tomography.

Figure 2

Bronchoscopy examination and
interventional treatment. (A) Broad pedicle mass in tracheal area
II. (B) Upper edge of the silicone stent. (C) Lower edge of the
silicone stent, with the black arrow indicating the site of tumor
recurrence. (D) Under bronchoscopy, the bronchoscope and the
optical fiber (white columnar object) for PDT were visible, closely
attached to the tumor recurrence site. (E) Local mucosal redness
and swelling after PDT. (F) Bronchoscopy reexamination 1 month
after PDT showed white necrotic material. PDT, photodynamic
therapy.

Figure 3

Comprehensive patient treatment
timeline. TACC, tracheal adenoic cystic carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Yang L, Wang L, Wang H and Zou H: Photodynamic therapy with local‑targeted perfusion for recurrent tracheal adenoid cystic carcinoma achieving 12‑year survival: A case report. Oncol Lett 31: 18, 2026.
APA
Yang, L., Wang, L., Wang, H., & Zou, H. (2026). Photodynamic therapy with local‑targeted perfusion for recurrent tracheal adenoid cystic carcinoma achieving 12‑year survival: A case report. Oncology Letters, 31, 18. https://doi.org/10.3892/ol.2025.15371
MLA
Yang, L., Wang, L., Wang, H., Zou, H."Photodynamic therapy with local‑targeted perfusion for recurrent tracheal adenoid cystic carcinoma achieving 12‑year survival: A case report". Oncology Letters 31.1 (2026): 18.
Chicago
Yang, L., Wang, L., Wang, H., Zou, H."Photodynamic therapy with local‑targeted perfusion for recurrent tracheal adenoid cystic carcinoma achieving 12‑year survival: A case report". Oncology Letters 31, no. 1 (2026): 18. https://doi.org/10.3892/ol.2025.15371
Copy and paste a formatted citation
x
Spandidos Publications style
Yang L, Wang L, Wang H and Zou H: Photodynamic therapy with local‑targeted perfusion for recurrent tracheal adenoid cystic carcinoma achieving 12‑year survival: A case report. Oncol Lett 31: 18, 2026.
APA
Yang, L., Wang, L., Wang, H., & Zou, H. (2026). Photodynamic therapy with local‑targeted perfusion for recurrent tracheal adenoid cystic carcinoma achieving 12‑year survival: A case report. Oncology Letters, 31, 18. https://doi.org/10.3892/ol.2025.15371
MLA
Yang, L., Wang, L., Wang, H., Zou, H."Photodynamic therapy with local‑targeted perfusion for recurrent tracheal adenoid cystic carcinoma achieving 12‑year survival: A case report". Oncology Letters 31.1 (2026): 18.
Chicago
Yang, L., Wang, L., Wang, H., Zou, H."Photodynamic therapy with local‑targeted perfusion for recurrent tracheal adenoid cystic carcinoma achieving 12‑year survival: A case report". Oncology Letters 31, no. 1 (2026): 18. https://doi.org/10.3892/ol.2025.15371
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