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Case Report Open Access

Remarkable response to Osimertinib plus Gumarontinib for EGFR mutation and concomitant MET exon 14 skipping in a patient with lung adenocarcinoma: A case report

  • Authors:
    • Xuquan Jing
    • Li Li
    • Shuangqing Lu
    • Xiaoyang Zhai
    • Hui Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China
    Copyright: © Jing et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 32
    |
    Published online on: November 12, 2025
       https://doi.org/10.3892/ol.2025.15385
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Abstract

The evaluation of individuals with lung cancer for the presence of oncogenic mutations and the subsequent administration of personalized targeted therapies are of significance in clinical practice. Epidermal growth factor receptor (EGFR) mutation and mesenchymal‑epithelial transition (MET) exon 14 skipping mutation were previously found to be mutually exclusive. The co‑occurrence of these mutations in individuals diagnosed with adenocarcinomas signifies a distinctive and uncommon molecular subtype of non‑small cell lung cancer. A 70‑year‑old man was admitted to Shandong Cancer Hospital and Institute (Jinan, Chian) with a 1‑month history of chest pain. The CT scanning findings indicated the presence of a 5.8x5.6 cm mass in the left lower lobe, accompanied by enlarged mediastinal and hilar lymph nodes, as well as metastases in both lungs and bones. Analysis of a biopsy specimen showed lung adenocarcinoma. Gene examination revealed EGFR Del19 mutation and concomitant MET exon 14 skipping mutation. Osimertinib and Gumarontinib were administered for 8 months and the efficacy was determined to be a partial response. The present study marks the initial discovery of MET exon 14 skipping and EGFR Del19 in a single patient, who achieved partial response through a treatment plan involving Osimertinib and Gumarontinib. These findings provide valuable perspectives on treatment approaches for individuals sharing similar genetic profiles.
View Figures

Figure 1

CT scans of the patient showing a left
lower lobe nodule (A) prior to treatment with osimertinib and
gumarontinib and at (B) one month, (C) 3 months and (D) 6 months
follow-up. CT imaging indicated a partial response according to the
Response Evaluation Criteria In Solid Tumors.

Figure 2

(A) H&E staining of the lung
biopsy showed lung adenocarcinoma (scale bar, 50 µm; original
magnification, ×400). (B) Mutation of EGFR exon 19 deletion. (C)
Mutation of MET exon 14 skipping. (D) Immunohistochemical analysis
of programmed cell death ligand 1 (PD-L1) expression.
Representative photomicrograph shows negative PD-L1 staining in
tumor cells. Note the positive brown membranous staining in
adjacent infiltrating immune cells, which serves as an positive
control. Tissue sections were counterstained with hematoxylin
(scale bar, 50 µm; original magnification, ×400).
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Copy and paste a formatted citation
Spandidos Publications style
Jing X, Li L, Lu S, Zhai X and Zhu H: Remarkable response to Osimertinib plus Gumarontinib for EGFR mutation and concomitant MET exon 14 skipping in a patient with lung adenocarcinoma: A case report. Oncol Lett 31: 32, 2026.
APA
Jing, X., Li, L., Lu, S., Zhai, X., & Zhu, H. (2026). Remarkable response to Osimertinib plus Gumarontinib for EGFR mutation and concomitant MET exon 14 skipping in a patient with lung adenocarcinoma: A case report. Oncology Letters, 31, 32. https://doi.org/10.3892/ol.2025.15385
MLA
Jing, X., Li, L., Lu, S., Zhai, X., Zhu, H."Remarkable response to Osimertinib plus Gumarontinib for EGFR mutation and concomitant MET exon 14 skipping in a patient with lung adenocarcinoma: A case report". Oncology Letters 31.1 (2026): 32.
Chicago
Jing, X., Li, L., Lu, S., Zhai, X., Zhu, H."Remarkable response to Osimertinib plus Gumarontinib for EGFR mutation and concomitant MET exon 14 skipping in a patient with lung adenocarcinoma: A case report". Oncology Letters 31, no. 1 (2026): 32. https://doi.org/10.3892/ol.2025.15385
Copy and paste a formatted citation
x
Spandidos Publications style
Jing X, Li L, Lu S, Zhai X and Zhu H: Remarkable response to Osimertinib plus Gumarontinib for EGFR mutation and concomitant MET exon 14 skipping in a patient with lung adenocarcinoma: A case report. Oncol Lett 31: 32, 2026.
APA
Jing, X., Li, L., Lu, S., Zhai, X., & Zhu, H. (2026). Remarkable response to Osimertinib plus Gumarontinib for EGFR mutation and concomitant MET exon 14 skipping in a patient with lung adenocarcinoma: A case report. Oncology Letters, 31, 32. https://doi.org/10.3892/ol.2025.15385
MLA
Jing, X., Li, L., Lu, S., Zhai, X., Zhu, H."Remarkable response to Osimertinib plus Gumarontinib for EGFR mutation and concomitant MET exon 14 skipping in a patient with lung adenocarcinoma: A case report". Oncology Letters 31.1 (2026): 32.
Chicago
Jing, X., Li, L., Lu, S., Zhai, X., Zhu, H."Remarkable response to Osimertinib plus Gumarontinib for EGFR mutation and concomitant MET exon 14 skipping in a patient with lung adenocarcinoma: A case report". Oncology Letters 31, no. 1 (2026): 32. https://doi.org/10.3892/ol.2025.15385
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