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Article

TAS‑102 plus bevacizumab as salvage treatment in colorectal cancer: A retrospective study

  • Authors:
    • Keita Matsumoto
    • Ryoma Yokoi
    • Chika Mizutani
    • Ryuichi Asai
    • Jesse Yu Tajima
    • Masahide Endo
    • Yuji Hatanaka
    • Takeshi Horaguchi
    • Masahiro Fukada
    • Itaru Yasufuku
    • Yuta Sato
    • Yoshihiro Tanaka
    • Katsutoshi Murase
    • Nobuhisa Matsuhashi
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Graduate School of Medicine, Gifu University Hospital, Gifu University, Gifu, Gifu 501‑1194, Japan
  • Article Number: 34
    |
    Published online on: November 14, 2025
       https://doi.org/10.3892/ol.2025.15387
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Abstract

The current study aimed to evaluate the efficacy and safety of TAS‑102 plus bevacizumab therapy as a salvage treatment for colorectal cancer, focusing on the differences between colon and rectal cancers. The present single‑center retrospective study enrolled 101 patients treated with TAS‑102 between October 2016 and December 2023 (median age, 67 years; 65 men and 36 women). The tumors included 16, 23 and 62 lesions in the right colon, left colon and rectum, respectively. The chemotherapy history included fluoropyrimidine (101 patients, 100%), oxaliplatin (95 patients, 94.1%), irinotecan (82 patients, 81.2%), anti‑vascular endothelial growth factor antibody (92 patients, 91.1%) and anti‑epidermal growth factor receptor antibody (41 patients, accounting for 87.2% of the RAS wild‑type subgroup). The median duration of TAS‑102 plus bevacizumab treatment was 184 days. A subsequent line of chemotherapy was administered in 66 patients (65.3%). The progression‑free survival (PFS) time was 5.6 months, whereas the overall survival (OS) time was 14.2 months. Colon and rectal cancers exhibited a PFS of 4.0 and 6.9 months, and an OS of 11.0 and 17.6 months, respectively. The results of the present study suggested that TAS‑102 combined with bevacizumab in subsequent treatment may have greater efficacy in rectal cancer than in colon cancer, possibly due to the lower frequency of liver metastases in rectal cancer. However, this finding is exploratory and requires further validation via larger prospective studies.
View Figures

Figure 1

(A) Distribution of TAS-102 plus BEV
treatment duration. The median duration was 184 days, with most
patients discontinuing the treatment within 9 months and the
longest treatment duration lasting nearly 2 years. (B) Relationship
between TAS-102 treatment days and BEV administration, with a
positive correlation between the two parameters. Generally,
patients with a longer TAS-102 treatment course underwent more BEV
cycles. BEV, bevacizumab.

Figure 2

Kaplan-Meier curves of OS and PFS in
101 patients with colorectal cancer treated with TAS-102 plus
bevacizumab. The median OS was 14.2 months (95% CI, 12.1–17.4), and
the median PFS was 5.6 months (95% CI, 4.0–6.9). OS, overall
survival; PFS, progression-free survival; CI, confidence
interval.

Figure 3

Comparison of OS and PFS according to
(A) RAS status, (B) colon or rectal cancer, (C) history of
anti-VEGF antibody administration and (D) timing of treatment
administration. Median survival times with 95% CIs and hazard
ratios were estimated using the Cox proportional hazards model
(univariable analysis). Survival curves were compared using the
log-rank and Gehan-Breslow-Wilcoxon tests. OS, overall survival;
PFS, progression-free survival; VEGF, vascular endothelial growth
factor; CI, confidence interval.

Figure 4

Comparison of OS and PFS according to
liver metastasis status. Median survival times with 95% CIs and
hazard ratios were estimated using the Cox proportional hazards
model (univariable analysis). Survival curves were compared using
the log-rank and Gehan-Breslow-Wilcoxon tests. OS, overall
survival; PFS, progression-free survival; CI, confidence
interval.
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Copy and paste a formatted citation
Spandidos Publications style
Matsumoto K, Yokoi R, Mizutani C, Asai R, Tajima JY, Endo M, Hatanaka Y, Horaguchi T, Fukada M, Yasufuku I, Yasufuku I, et al: TAS‑102 plus bevacizumab as salvage treatment in colorectal cancer: A retrospective study. Oncol Lett 31: 34, 2026.
APA
Matsumoto, K., Yokoi, R., Mizutani, C., Asai, R., Tajima, J.Y., Endo, M. ... Matsuhashi, N. (2026). TAS‑102 plus bevacizumab as salvage treatment in colorectal cancer: A retrospective study. Oncology Letters, 31, 34. https://doi.org/10.3892/ol.2025.15387
MLA
Matsumoto, K., Yokoi, R., Mizutani, C., Asai, R., Tajima, J. Y., Endo, M., Hatanaka, Y., Horaguchi, T., Fukada, M., Yasufuku, I., Sato, Y., Tanaka, Y., Murase, K., Matsuhashi, N."TAS‑102 plus bevacizumab as salvage treatment in colorectal cancer: A retrospective study". Oncology Letters 31.1 (2026): 34.
Chicago
Matsumoto, K., Yokoi, R., Mizutani, C., Asai, R., Tajima, J. Y., Endo, M., Hatanaka, Y., Horaguchi, T., Fukada, M., Yasufuku, I., Sato, Y., Tanaka, Y., Murase, K., Matsuhashi, N."TAS‑102 plus bevacizumab as salvage treatment in colorectal cancer: A retrospective study". Oncology Letters 31, no. 1 (2026): 34. https://doi.org/10.3892/ol.2025.15387
Copy and paste a formatted citation
x
Spandidos Publications style
Matsumoto K, Yokoi R, Mizutani C, Asai R, Tajima JY, Endo M, Hatanaka Y, Horaguchi T, Fukada M, Yasufuku I, Yasufuku I, et al: TAS‑102 plus bevacizumab as salvage treatment in colorectal cancer: A retrospective study. Oncol Lett 31: 34, 2026.
APA
Matsumoto, K., Yokoi, R., Mizutani, C., Asai, R., Tajima, J.Y., Endo, M. ... Matsuhashi, N. (2026). TAS‑102 plus bevacizumab as salvage treatment in colorectal cancer: A retrospective study. Oncology Letters, 31, 34. https://doi.org/10.3892/ol.2025.15387
MLA
Matsumoto, K., Yokoi, R., Mizutani, C., Asai, R., Tajima, J. Y., Endo, M., Hatanaka, Y., Horaguchi, T., Fukada, M., Yasufuku, I., Sato, Y., Tanaka, Y., Murase, K., Matsuhashi, N."TAS‑102 plus bevacizumab as salvage treatment in colorectal cancer: A retrospective study". Oncology Letters 31.1 (2026): 34.
Chicago
Matsumoto, K., Yokoi, R., Mizutani, C., Asai, R., Tajima, J. Y., Endo, M., Hatanaka, Y., Horaguchi, T., Fukada, M., Yasufuku, I., Sato, Y., Tanaka, Y., Murase, K., Matsuhashi, N."TAS‑102 plus bevacizumab as salvage treatment in colorectal cancer: A retrospective study". Oncology Letters 31, no. 1 (2026): 34. https://doi.org/10.3892/ol.2025.15387
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