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Article

Retrospective analysis of the association between monocyte percentage and outcomes in newly diagnosed diffuse large B‑cell lymphoma

  • Authors:
    • Chaoqiang Zheng
    • Xiaoqin Xin
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Ganzhou People's Hospital, Ganzhou, Jiangxi 341000, P.R. China
  • Article Number: 58
    |
    Published online on: November 28, 2025
       https://doi.org/10.3892/ol.2025.15411
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Abstract

The aim of the present study was to analyze the prognostic value of monocyte percentage (MP) at diagnosis in patients with diffuse large B‑cell lymphoma (DLBCL). Overall, 169 patients with newly diagnosed DLBCL who were treated with rituximab‑based therapy at the Department of Hematology, Ganzhou People's Hospital (Ganzhou, China) between January 2015 and December 2023 were retrospectively analyzed. Univariate and multivariate analyses were used to assess the impact of MP and clinical characteristics on prognosis. Kaplan‑Meier curves and log‑rank tests were used to analyze progression‑free survival (PFS) and overall survival (OS). The prediction performance for OS was assessed using receiver operating characteristic (ROC) analysis. A total of 16 patients passed away during the follow‑up, whereas 53 patients experienced disease progression/relapse. Patients were divided into groups with low (≤10%) and high (>10%) MPs, with 10% serving as the cutoff. A high MP was independently associated with worse PFS (hazard ratio, 2.54; 95% confidence interval, 1.08‑5.99; P=0.033) and OS (P<0.05). When MP was combined with International Prognostic Index (IPI) scores, predictive accuracy was significantly higher than upon using IPI alone (area under the ROC curve, 0.907 vs. 0.792, respectively; P=0.043). In conclusion, in patients with DLBCL, a high MP at diagnosis is significantly associated with poor survival outcomes. Combining MP with IPI score improves prognostic stratification.
View Figures

Figure 1

Kaplan-Meier curves for (A) PFS and
(B) OS probability comparing low (≤10%) and high (>10%) MP. (C)
Receiver operating characteristic curve analysis for the prediction
of OS in patients with diffuse large B-cell lymphoma. Model 1
(blue) represents IPI scores, model 2 (red) includes IPI scores and
MP. MP, monocyte percentage; IPI, International Prognostic Index;
PFS, progression-free survival; OS, overall survival; AUC, area
under the receiver operating characteristic curve.
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Copy and paste a formatted citation
Spandidos Publications style
Zheng C and Xin X: Retrospective analysis of the association between monocyte percentage and outcomes in newly diagnosed diffuse large B‑cell lymphoma. Oncol Lett 31: 58, 2026.
APA
Zheng, C., & Xin, X. (2026). Retrospective analysis of the association between monocyte percentage and outcomes in newly diagnosed diffuse large B‑cell lymphoma. Oncology Letters, 31, 58. https://doi.org/10.3892/ol.2025.15411
MLA
Zheng, C., Xin, X."Retrospective analysis of the association between monocyte percentage and outcomes in newly diagnosed diffuse large B‑cell lymphoma". Oncology Letters 31.2 (2026): 58.
Chicago
Zheng, C., Xin, X."Retrospective analysis of the association between monocyte percentage and outcomes in newly diagnosed diffuse large B‑cell lymphoma". Oncology Letters 31, no. 2 (2026): 58. https://doi.org/10.3892/ol.2025.15411
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng C and Xin X: Retrospective analysis of the association between monocyte percentage and outcomes in newly diagnosed diffuse large B‑cell lymphoma. Oncol Lett 31: 58, 2026.
APA
Zheng, C., & Xin, X. (2026). Retrospective analysis of the association between monocyte percentage and outcomes in newly diagnosed diffuse large B‑cell lymphoma. Oncology Letters, 31, 58. https://doi.org/10.3892/ol.2025.15411
MLA
Zheng, C., Xin, X."Retrospective analysis of the association between monocyte percentage and outcomes in newly diagnosed diffuse large B‑cell lymphoma". Oncology Letters 31.2 (2026): 58.
Chicago
Zheng, C., Xin, X."Retrospective analysis of the association between monocyte percentage and outcomes in newly diagnosed diffuse large B‑cell lymphoma". Oncology Letters 31, no. 2 (2026): 58. https://doi.org/10.3892/ol.2025.15411
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