Epstein‑Barr virus<sup>+</sup> inflammatory follicular dendritic cell sarcoma with clonal immunoglobulin heavy chain gene rearrangement: A case report and literature review

Ye,Qian; Zhao,Juan; He,Jiao; Zhang,Weishan

doi:10.3892/ol.2025.15426

February-2026 Volume 31 Issue 2

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February-2026 Volume 31 Issue 2

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Case Report Open Access

Epstein‑Barr virus⁺ inflammatory follicular dendritic cell sarcoma with clonal immunoglobulin heavy chain gene rearrangement: A case report and literature review

Authors:
- Qian Ye
- Juan Zhao
- Jiao He
- Weishan Zhang
View Affiliations / Copyright

Affiliations: Department of Pathology, Suining Central Hospital, Suining, Sichuan 629000, P.R. China

Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 73
|
Published online on: December 9, 2025

https://doi.org/10.3892/ol.2025.15426
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Abstract

Epstein‑Barr virus⁺ inflammatory follicular dendritic cell sarcoma (EBV⁺ IFDCS) is a tumor with relatively inert biological behavior and low malignancy. Due to the lack of clinical features and non‑specific imaging examinations, EBV⁺ IFDCS is difficult to diagnose preoperatively. The histological morphology and immunophenotype of EBV⁺ IFDCS are very broad, in which the presentation of EBV⁺ IFDCS with marked granulomatous changes is rare and can be confused with other granulomatous diseases. The present study reported a case of EBV⁺ IFDCS with marked granuloma formation. Notably, the present case report detected gene rearrangements using PCR‑capillary electrophoresis and identified an amplification peak in the DH7‑JH region of the immunoglobulin heavy chain, which has rarely been reported in previous cases, to the best of our knowledge. We hypothesized that this rearrangement may be associated with background B cells.

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