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Article

Construction of a novel prediction model based on albumin‑hemoglobin score and serum microRNA-497‑5p for prognosis of patients with stage II‑III colorectal cancer

  • Authors:
    • Qian Wang
    • Hailiang Wang
    • Lingling Liu
    • Zhen Wang
  • View Affiliations / Copyright

    Affiliations: Department of Basic Medical Sciences, Tianjin Medical College, Tianjin 300222, P.R. China, Department of General Surgery, Tianjin Haihe Hospital, Tianjin 300350, P.R. China, Department of Radiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, P.R. China, Siemens Healthineers, Beijing 100102, P.R. China
  • Article Number: 79
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    Published online on: December 17, 2025
       https://doi.org/10.3892/ol.2025.15432
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Abstract

Stage II‑III colorectal cancer (CRC) represents the initial phase of tumor invasion and lymph node metastasis. Surgery is the preferred treatment option for patients at this stage, however, due to the complex progression mechanisms of the disease, incomplete tumor resection, postoperative cancer cell metastasis, and the development of drug resistance to chemotherapy often lead to poor prognosis. The present study aimed to investigate the status of poor postoperative prognosis in patients with stage II‑III CRC following radical surgery, analyze the impact of preoperative albumin‑hemoglobin (ALB‑Hb) score and serum microRNA‑497‑5p (miR‑497‑5p) levels on adverse outcomes and develop a predictive model for poor prognosis. Baseline data of 154 patients with stage II‑III CRC treated at Tianjin Haihe Hospital (Tianjin, China) or Guangzhou First People's Hospital (Guangzhou, China) between December 2021 and December 2024 were retrospectively selected. Patients were stratified into the poor and good prognosis groups based on clinical outcomes. Univariate analysis was performed on baseline characteristics and laboratory parameters. Variables demonstrating notable differences were subsequently evaluated for multicollinearity. Factors without collinearity were incorporated into a Cox proportional hazards regression model to identify determinants of postoperative prognosis in patients treated with radical resection. These predictors were then used to construct a prognostic nomogram, with model accuracy verified through calibration curves. Among the 154 patients with stage II‑III CRC, 63 cases (40.91%) had poor prognosis and 91 cases (59.09%) had good prognosis. Univariate and collinearity analyses revealed marked differences in preoperative levels of miR‑497‑5p, Kallikrein‑related peptidase 5 (KLK5), angiopoietin‑2 (Ang‑2) and ALB‑Hb scores, with no collinearity observed (P<0.05; variation inflation factor ≤10; tolerance ≥0.1). Cox proportional hazards regression model demonstrated that all these indicators were independent factors influencing poor prognosis following radical surgery in patients with stage II‑III CRC (all P<0.05). Based on these findings, a nomogram was constructed and calibration curves closely approximated the ideal curve. Preoperative ALB, Hb, miR‑497‑5p, KLK5, Ang‑2 levels and ALB‑Hb scores were notable prognostic factors for patients with stage II‑III CRC following radical resection, demonstrating high predictive value for poor postoperative outcomes. The present study provided clinically relevant indicators to screen high‑risk patients with potential poor prognosis following radical surgery for stages II‑III CRC.
View Figures

Figure 1

Nomogram and calibration curves to
predict the prognosis of patients with stage II–III colorectal
cancer. (A) Nomogram; (B) Calibration curve. ALB, albumin; Hb,
hemoglobin; miR, microRNA; KLK5, Kallikrein-related peptidase 5;
Ang-2, angiopoeitin-2.
View References

1 

Siegel RL, Wagle NS, Cercek A, Smith RA and Jemal A: Colorectal cancer statistics, 2023. CA Cancer J Clin. 73:233–254. 2023.PubMed/NCBI

2 

Li X, Jonnagaddala J, Yang S, Zhang H and Xu XS: A retrospective analysis using deep-learning models for prediction of survival outcome and benefit of adjuvant chemotherapy in stage II/III colorectal cancer. J Cancer Res Clin Oncol. 148:1955–1963. 2022. View Article : Google Scholar : PubMed/NCBI

3 

Nakamura Y, Yamaura T, Kinjo Y, Harada K, Kawase M, Kawabata Y, Kanto S, Ogo Y and Kuroda N: Level of inferior mesenteric artery ligation in sigmoid colon and rectal cancer surgery: analysis of apical lymph node metastasis and recurrence. Dig Surg. 40:167–177. 2023. View Article : Google Scholar : PubMed/NCBI

4 

Geng S, Yu X and Yu S: Efficacy and safety of natural killer cells injection combined with XELOX chemotherapy in postoperative patients with stage III colorectal cancer in China: A prospective randomised controlled clinical trial study protocol. BMJ Open. 14:e0803772024. View Article : Google Scholar : PubMed/NCBI

5 

Kobayashi K, Ono Y, Kitano Y, Oba A, Sato T, Ito H, Mise Y, Shinozaki E, Inoue Y, Yamaguchi K, et al: Prognostic impact of tumor markers (CEA and CA19-9) on patients with resectable colorectal liver metastases stratified by tumor number and size: Potentially valuable biologic markers for preoperative treatment. Ann Surg Oncol. 30:7338–7347. 2023. View Article : Google Scholar : PubMed/NCBI

6 

Grange R, Rousset P, Williet N, Guesnon M, Milot L, Passot G, Phelip JM, Le Roy B, Glehen O and Kepenekian V: Metastatic colorectal cancer treated with combined liver resection, cytoreductive surgery, and hyperthermic intraperitoneal chemotherapy (HIPEC): Predictive factors for early recurrence. Ann Surg Oncol. 31:2378–2390. 2024. View Article : Google Scholar : PubMed/NCBI

7 

Elfiky AM, Eid MM, El-Manawaty M, Elshahid ZA, Youssef EM and Mahmoud K: Production of novel theranostic nano-vector based on superparamagnetic iron oxide nanoparticles/miR-497 targeting colorectal cancer. Sci Rep. 15:42472025. View Article : Google Scholar : PubMed/NCBI

8 

Han S, Chen Y, Wang Y and Xu H: Application of problem-oriented nursing model combined with early enteral nutrition support in the perioperative period of stage II/III gastric cancer patients. Nutr Cancer. 77:1028–1034. 2025. View Article : Google Scholar : PubMed/NCBI

9 

Zhao Q, Li Y and Wang T: Development and validation of prediction model for early warning of ovarian metastasis risk of endometrial carcinoma. Medicine (Baltimore). 102:e354392023. View Article : Google Scholar : PubMed/NCBI

10 

Lu J, Du L, Lei X and Zhang Z: Prognostic value of esophageal cancer immune prognostic index in advanced esophageal squamous cell carcinoma patients with anti-programmed cell death-1 therapy. Cancer Med. 12:11334–11343. 2023. View Article : Google Scholar : PubMed/NCBI

11 

Peng Q, Shen Y, Zhao P, Cheng M, Wu Y and Zhu Y: Biomarker implication of kallikrein-related peptidases as prognostic tissue substrates of poor survival in colorectal cancer. Cancer Cell Int. 20:2602020. View Article : Google Scholar : PubMed/NCBI

12 

Abuduhadeer X, Xu X, Aihesan K, Yilihamu M, Zhao Y and Zhang W: Clinical significance of kallikrein 5 as a novel prognostic biomarker in gastric adenocarcinoma. J Clin Lab Anal. 35:e239582021. View Article : Google Scholar : PubMed/NCBI

13 

Huang X, Zheng S, Li S, Huang Y, Zhang W, Liu F and Cao Q: Machine learning-based pathomics model predicts angiopoietin-2 expression and prognosis in hepatocellular carcinoma. Am J Pathol. 195:561–574. 2025. View Article : Google Scholar : PubMed/NCBI

14 

Zheng J, Du PZ, Yang C, Tao YY, Li L, Li ZM and Yang L: DCE-MRI-based radiomics in predicting angiopoietin-2 expression in hepatocellular carcinoma. Abdom Radiol (NY). 48:3343–3352. 2023. View Article : Google Scholar : PubMed/NCBI

15 

Saeed A, Park R, Pathak H, Al-Bzour AN, Dai J, Phadnis M, Al-Rajabi R, Kasi A, Baranda J, Sun W, et al: Clinical and biomarker results from a phase II trial of combined cabozantinib and durvalumab in patients with chemotherapy-refractory colorectal cancer (CRC): CAMILLA CRC cohort. Nat Commun. 15:15332024. View Article : Google Scholar : PubMed/NCBI

16 

Ishikawa S, Hirano Y, Deguchi K, Ishii T, Ishiyama Y, Okazaki N, Fujii T, Kataoka A, Sasaki M, Shimamura S and Yonezawa H: Risk factors for lymph node metastasis and recurrence in T1 colorectal cancer: analysis of 801 patients in a single institute. Am Surg. 89:5312–5317. 2023. View Article : Google Scholar : PubMed/NCBI

17 

Ishimaru K, Kawai K, Nozawa H, Sasaki K, Murono K, Emoto S, Ishii H, Anzai H, Sonoda H, Yamauchi S, et al: Hazard function analysis of metastatic recurrence after colorectal cancer surgery-A nationwide retrospective study. J Surg Oncol. 123:1015–1022. 2021. View Article : Google Scholar : PubMed/NCBI

18 

Koedam TWA, Bootsma BT, Deijen CL, van de Brug T, Kazemier G, Cuesta MA, Fürst A, Lacy AM, Haglind E, Tuynman JB, et al: Oncological outcomes after anastomotic leakage after surgery for colon or rectal cancer: Increased risk of local recurrence. Ann Surg. 275:e420–e427. 2022. View Article : Google Scholar : PubMed/NCBI

19 

Alkader MS, Al-Majthoub MZ, Al-Qerem WA, Alkhader DM, Alhusban AM, Abdulkareem MA, Abweny B, Hamawi AT, Muslem HF, Omeish RA, et al: Prognostic factors influencing survival in stage II and stage III colorectal cancer patients. Cureus. 15:e465752023.PubMed/NCBI

20 

Dinart D, Bellera C and Rondeau V: Sample size estimation for cancer randomized trials in the presence of heterogeneous populations. Biometrics. 78:1662–1673. 2022. View Article : Google Scholar : PubMed/NCBI

21 

Argilés G, Tabernero J, Labianca R, Hochhauser D, Salazar R, Iveson T, Laurent-Puig P, Quirke P, Yoshino T, Taieb J, et al: Localised colon cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 31:1291–1305. 2020. View Article : Google Scholar : PubMed/NCBI

22 

Morris VK, Kennedy EB, Baxter NN, Benson AB III, Cercek A, Cho M, Ciombor KK, Cremolini C, Davis A, Deming DA, et al: Treatment of metastatic colorectal cancer: ASCO guideline. J Clin Oncol. 41:678–700. 2023. View Article : Google Scholar : PubMed/NCBI

23 

Yang Y, Yang Z, Lyu Z, Ouyang K, Wang J, Wu D and Li Y: Pathological-features-modified TNM staging system improves prognostic accuracy for rectal cancer. Dis Colon Rectum. 67:645–654. 2024. View Article : Google Scholar : PubMed/NCBI

24 

Shiina O, Kudo SE, Ichimasa K, Takashina Y, Kouyama Y, Mochizuki K, Morita Y, Kuroki T, Kato S, Nakamura H, et al: Differentiation grade as a risk factor for lymph node metastasis in T1 colorectal cancer. DEN Open. 4:e3242023. View Article : Google Scholar : PubMed/NCBI

25 

Joanito I, Wirapati P, Zhao N, Nawaz Z, Yeo G, Lee F, Eng CLP, Macalinao DC, Kahraman M, Srinivasan H, et al: Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer. Nat Genet. 54:963–975. 2022. View Article : Google Scholar : PubMed/NCBI

26 

Tan Y, Liu R, Xue JW and Feng Z: Construction and validation of artificial intelligence pathomics models for predicting pathological staging in colorectal cancer: Using multimodal data and clinical variables. Cancer Med. 13:e69472024. View Article : Google Scholar : PubMed/NCBI

27 

Yu C and Zhang F: LncRNA AC009022.1 enhances colorectal cancer cells proliferation, migration, and invasion by promoting ACTR3B expression via suppressing miR-497-5p. J Cell Biochem. 121:1934–1944. 2020. View Article : Google Scholar : PubMed/NCBI

28 

Zhou J and Yang D: Prognostic significance of hemoglobin, albumin, lymphocyte and platelet (HALP) score in hepatocellular carcinoma. J Hepatocell Carcinoma. 10:821–831. 2023. View Article : Google Scholar : PubMed/NCBI

29 

Zhang W, Zhang X, Zhao D, Hu M, Ge X and Xia L: An individualized EMT-related gene signature to predict recurrence-free survival in stage II/III colorectal cancer patients. Dig Dis Sci. 67:5116–5126. 2022. View Article : Google Scholar : PubMed/NCBI

30 

Gattuso G, Longo F, Spoto G, Ricci D, Lavoro A, Candido S, Di Cataldo A, Broggi G, Salvatorelli L, Magro G, et al: Diagnostic and prognostic significance of a four-miRNA signature in colorectal cancer. Int J Mol Sci. 26:12192025. View Article : Google Scholar : PubMed/NCBI

31 

Li J, Lei C, Chen B and Zhu Q: LncRNA FGD5-AS1 facilitates the radioresistance of breast cancer cells by enhancing MACC1 expression through competitively sponging miR-497-5p. Front Oncol. 11:6718532021. View Article : Google Scholar : PubMed/NCBI

32 

Kattan SW, Hobani YH, Abubakr Babteen N, Alghamdi SA, Toraih EA, Ibrahiem AT, Fawzy MS and Faisal S: Association of B-cell lymphoma 2/microRNA-497 gene expression ratio score with metastasis in patients with colorectal cancer: A propensity-matched cohort analysis. J Clin Lab Anal. 36:e242272022. View Article : Google Scholar : PubMed/NCBI

33 

Song M and Liu J: Circ_0067717 promotes colorectal cancer cell growth, invasion and glutamine metabolism by serving as a miR-497-5p sponge to upregulate SLC7A5. Histol Histopathol. 38:53–64. 2023.PubMed/NCBI

34 

Bai J, Xu J, Zhao J and Zhang R: lncRNA SNHG1 cooperated with miR-497/miR-195-5p to modify epithelial-mesenchymal transition underlying colorectal cancer exacerbation. J Cell Physiol. 235:1453–1468. 2020. View Article : Google Scholar : PubMed/NCBI

35 

Chen K, Wang Z, Zong QB, Zhou MY and Chen QF: miR-497-5p-RSPO2 axis inhibits cell growth and metastasis in glioblastoma. J Cancer. 13:1241–1251. 2022. View Article : Google Scholar : PubMed/NCBI

36 

Zhao X, Dou LZ, Zhang YM, Liu Y, He S, Ke Y, Liu XD, Liu YM, Wu HR, Li ZQ, et al: Risk factors for residual cancer or lymph node metastasis after endoscopic noncurable resection of early colorectal cancer. Zhonghua Zhong Liu Za Zhi. 45:335–339. 2023.(In Chinese). PubMed/NCBI

37 

Wang L, Chen X, Zhang H, Hong L, Wang J, Shao L, Chen G and Wu J: Comprehensive analysis of transient receptor potential channels-related signature for prognosis, tumor immune microenvironment, and treatment response of colorectal cancer. Front Immunol. 13:10148342022. View Article : Google Scholar : PubMed/NCBI

38 

Zhang Z, Liang Y, Zhong D, Dai Z, Shang J, Lai C, Zou H, Yao Y, Feng T and Huang X: Prognostic value of inflammation-immunity-nutrition score in patients with hepatocellular carcinoma treated with anti-PD-1 therapy. J Clin Lab Anal. 36:e243362022. View Article : Google Scholar : PubMed/NCBI

39 

Lv Q, Rao SQ and Xiang Z: Preoperative hemoglobin to albumin ratio as a prognostic predictor for patients with colorectal cancer surgery. Updates Surg. 77:761–769. 2025. View Article : Google Scholar : PubMed/NCBI

40 

Záhorec R, Marek V, Waczulikova I, Veselovský T, Palaj J, Kečkéš Š and Durdík Š: Predictive model using hemoglobin, albumin, fibrinogen, and neutrophil-to-lymphocyte ratio to distinguish patients with colorectal cancer from those with benign adenoma. Neoplasma. 68:1292–1300. 2021. View Article : Google Scholar : PubMed/NCBI

41 

Li K, Yan J, Zhang H, Lu C, Wang W, Guo M, Zhang X and Zhang Z: Prognostic value of preoperative white blood cell to hemoglobin ratio and fibrinogen to albumin ratio in patients with colorectal cancer. Medicine (Baltimore). 103:e370312024. View Article : Google Scholar : PubMed/NCBI

42 

Ambrosio MR, Spagnoli L, Perotti B, Petrelli F, Caini S, Saieva C, Usai S, Bianchini M, Cavazzana A, Arganini M and Amorosi A: Paving the path for immune enhancing nutrition in colon cancer: Modulation of tumor microenvironment and optimization of outcomes and costs. Cancers (Basel). 15:4372023. View Article : Google Scholar : PubMed/NCBI

43 

Fang Y, Lin L, Ruan H and Qin X: Natural orifice specimen extraction surgery yields superior long-term oncological outcomes compared to traditional laparoscopic surgery in stage II–III rectal cancer. Am J Cancer Res. 15:3286–3298. 2025. View Article : Google Scholar : PubMed/NCBI

44 

Pei J, Gao Y and Wu A: An inflammation-related subtype classification for analyzing tumor microenvironment and clinical prognosis in colorectal cancer. Front Immunol. 15:13697262024. View Article : Google Scholar : PubMed/NCBI

45 

Chang JS, Kim N, Kim JY, Do SI, Cho Y, Kim HS and Kim YB: Kallikrein 5 overexpression is associated with poor prognosis in uterine cervical cancer. J Gynecol Oncol. 31:e782020. View Article : Google Scholar : PubMed/NCBI

46 

Alves MG, Kodama MH, da Silva EZM, Gomes BBM, da Silva RAA, Vieira GV, Alves VM, da Fonseca CK, Santana AC, Cecílio NT, et al: Relative expression of KLK5 to LEKTI is associated with aggressiveness of oral squamous cell carcinoma. Transl Oncol. 14:1009702021. View Article : Google Scholar : PubMed/NCBI

47 

Ao J, Chiba T, Kanzaki H, Kanayama K, Shibata S, Kurosugi A, Iwanaga T, Kan M, Sakuma T, Qiang N, et al: Serum angiopoietin 2 acts as a diagnostic and prognostic biomarker in hepatocellular carcinoma. J Cancer. 12:2694–2701. 2021. View Article : Google Scholar : PubMed/NCBI

48 

Song Y, Bai G, Li X, Zhou L, Si Y, Liu X, Deng Y and Shi Y: Bioinformatics analysis of human kallikrein 5 (KLK5) expression in metaplastic triple-negative breast cancer. Cancer Innov. 2:376–390. 2023. View Article : Google Scholar : PubMed/NCBI

49 

Kraljević M, Marijanović I, Barbarić M, Sokolović E, Bukva M, Cerić T and Buhovac T: Prognostic and predictive significance of VEGF, CD31, and Ang-1 in patients with metastatic clear cell renal cell carcinoma treated with first-line sunitinib. Biomol Biomed. 23:161–169. 2023. View Article : Google Scholar : PubMed/NCBI

50 

Papachristopoulou G, Malachias A, Devetzi M, Kamouza E, Scorilas A, Xynopoulos D and Talieri M: Uncovering the clinical impact of kallikrein-related peptidase 5 (KLK5) mRNA expression in the colorectal adenoma-carcinoma sequence. Clin Chem Lab Med. 57:1251–1260. 2019. View Article : Google Scholar : PubMed/NCBI

51 

Antoniotti C, Marmorino F, Boccaccino A, Martini S, Antista M, Rossini D, Zuco V, Prisciandaro M, Conca V, Zucchelli G, et al: Early modulation of Angiopoietin-2 plasma levels predicts benefit from regorafenib in patients with metastatic colorectal cancer. Eur J Cancer. 165:116–124. 2022. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang Q, Wang H, Liu L and Wang Z: Construction of a novel prediction model based on albumin‑hemoglobin score and serum microRNA-497‑5p for prognosis of patients with stage II‑III colorectal cancer. Oncol Lett 31: 79, 2026.
APA
Wang, Q., Wang, H., Liu, L., & Wang, Z. (2026). Construction of a novel prediction model based on albumin‑hemoglobin score and serum microRNA-497‑5p for prognosis of patients with stage II‑III colorectal cancer. Oncology Letters, 31, 79. https://doi.org/10.3892/ol.2025.15432
MLA
Wang, Q., Wang, H., Liu, L., Wang, Z."Construction of a novel prediction model based on albumin‑hemoglobin score and serum microRNA-497‑5p for prognosis of patients with stage II‑III colorectal cancer". Oncology Letters 31.2 (2026): 79.
Chicago
Wang, Q., Wang, H., Liu, L., Wang, Z."Construction of a novel prediction model based on albumin‑hemoglobin score and serum microRNA-497‑5p for prognosis of patients with stage II‑III colorectal cancer". Oncology Letters 31, no. 2 (2026): 79. https://doi.org/10.3892/ol.2025.15432
Copy and paste a formatted citation
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Spandidos Publications style
Wang Q, Wang H, Liu L and Wang Z: Construction of a novel prediction model based on albumin‑hemoglobin score and serum microRNA-497‑5p for prognosis of patients with stage II‑III colorectal cancer. Oncol Lett 31: 79, 2026.
APA
Wang, Q., Wang, H., Liu, L., & Wang, Z. (2026). Construction of a novel prediction model based on albumin‑hemoglobin score and serum microRNA-497‑5p for prognosis of patients with stage II‑III colorectal cancer. Oncology Letters, 31, 79. https://doi.org/10.3892/ol.2025.15432
MLA
Wang, Q., Wang, H., Liu, L., Wang, Z."Construction of a novel prediction model based on albumin‑hemoglobin score and serum microRNA-497‑5p for prognosis of patients with stage II‑III colorectal cancer". Oncology Letters 31.2 (2026): 79.
Chicago
Wang, Q., Wang, H., Liu, L., Wang, Z."Construction of a novel prediction model based on albumin‑hemoglobin score and serum microRNA-497‑5p for prognosis of patients with stage II‑III colorectal cancer". Oncology Letters 31, no. 2 (2026): 79. https://doi.org/10.3892/ol.2025.15432
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