Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
February-2026 Volume 31 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2026 Volume 31 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
Case Report Open Access

Individualized management strategies for advanced non‑small cell lung cancer with EGFR exon 19 deletion and L861Q compound mutations based on circulating tumor DNA monitoring: A case report

  • Authors:
    • Xiaobang Zhu
    • Ye Sun
    • Ruirui Cai
    • Wenbin Zhang
    • Xiangwei Zhang
    • Ailing Song
    • Xiaoyan Chen
    • Cuicui Liu
    • Jianping Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care Medicine, Wuxi Branch, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Wuxi, Jiangsu 214000, P.R. China, Department of Pathology, Wuxi Branch, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Wuxi, Jiangsu 214000, P.R. China, Geneseeq Research Institute, Nanjing Geneseeq Technology Inc., Nanjing, Jiangsu 210032, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 88
    |
    Published online on: December 23, 2025
       https://doi.org/10.3892/ol.2025.15441
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Epidermal growth factor receptor (EGFR) mutations are major oncogenic drivers in non‑small cell lung cancer (NSCLC). These alterations, particularly prevalent in lung adenocarcinoma among the Chinese population, include the exon 19 deletion (19del), L858R point mutation and the less frequent L861Q variant. However, to the best of our knowledge, no standardized treatment regimen exists for patients harboring both common and rare EGFR mutations. The current study presents a case of advanced metastatic lung adenocarcinoma with concurrent EGFR 19del and L861Q mutations, managed with tyrosine kinase inhibitors targeting EGFR and dynamic plasma circulating tumor DNA (ctDNA) monitoring. The patient achieved a progression‑free survival time of 11 months. Serial plasma ctDNA monitoring detected molecular progression, characterized by an increase in total ctDNA and a rising EGFR C797S allele fraction, prior to radiographic changes. The present case emphasized the importance of individualized management and the key role of ctDNA in real‑time treatment monitoring, offering a potentially novel approach for precise disease evaluation in the future. Further research and the development of novel therapies are warranted to potentially improve outcomes in patients with advanced EGFR‑mutated NSCLC.

Related Articles

  • Abstract
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhu X, Sun Y, Cai R, Zhang W, Zhang X, Song A, Chen X, Liu C and Zhou J: Individualized management strategies for advanced non‑small cell lung cancer with <em>EGFR</em> exon 19 deletion and L861Q compound mutations based on circulating tumor DNA monitoring: A case report. Oncol Lett 31: 88, 2026.
APA
Zhu, X., Sun, Y., Cai, R., Zhang, W., Zhang, X., Song, A. ... Zhou, J. (2026). Individualized management strategies for advanced non‑small cell lung cancer with <em>EGFR</em> exon 19 deletion and L861Q compound mutations based on circulating tumor DNA monitoring: A case report. Oncology Letters, 31, 88. https://doi.org/10.3892/ol.2025.15441
MLA
Zhu, X., Sun, Y., Cai, R., Zhang, W., Zhang, X., Song, A., Chen, X., Liu, C., Zhou, J."Individualized management strategies for advanced non‑small cell lung cancer with <em>EGFR</em> exon 19 deletion and L861Q compound mutations based on circulating tumor DNA monitoring: A case report". Oncology Letters 31.2 (2026): 88.
Chicago
Zhu, X., Sun, Y., Cai, R., Zhang, W., Zhang, X., Song, A., Chen, X., Liu, C., Zhou, J."Individualized management strategies for advanced non‑small cell lung cancer with <em>EGFR</em> exon 19 deletion and L861Q compound mutations based on circulating tumor DNA monitoring: A case report". Oncology Letters 31, no. 2 (2026): 88. https://doi.org/10.3892/ol.2025.15441
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu X, Sun Y, Cai R, Zhang W, Zhang X, Song A, Chen X, Liu C and Zhou J: Individualized management strategies for advanced non‑small cell lung cancer with <em>EGFR</em> exon 19 deletion and L861Q compound mutations based on circulating tumor DNA monitoring: A case report. Oncol Lett 31: 88, 2026.
APA
Zhu, X., Sun, Y., Cai, R., Zhang, W., Zhang, X., Song, A. ... Zhou, J. (2026). Individualized management strategies for advanced non‑small cell lung cancer with <em>EGFR</em> exon 19 deletion and L861Q compound mutations based on circulating tumor DNA monitoring: A case report. Oncology Letters, 31, 88. https://doi.org/10.3892/ol.2025.15441
MLA
Zhu, X., Sun, Y., Cai, R., Zhang, W., Zhang, X., Song, A., Chen, X., Liu, C., Zhou, J."Individualized management strategies for advanced non‑small cell lung cancer with <em>EGFR</em> exon 19 deletion and L861Q compound mutations based on circulating tumor DNA monitoring: A case report". Oncology Letters 31.2 (2026): 88.
Chicago
Zhu, X., Sun, Y., Cai, R., Zhang, W., Zhang, X., Song, A., Chen, X., Liu, C., Zhou, J."Individualized management strategies for advanced non‑small cell lung cancer with <em>EGFR</em> exon 19 deletion and L861Q compound mutations based on circulating tumor DNA monitoring: A case report". Oncology Letters 31, no. 2 (2026): 88. https://doi.org/10.3892/ol.2025.15441
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team