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February-2026 Volume 31 Issue 2

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Case Report Open Access

Metastatic urothelial carcinoma of the urethra and glans penis with reported implantation via the urine: A case report

  • Authors:
    • Piotr Kalinowski
    • Paweł Nalej
    • Beata Grochulska‑Nalazek
    • Tomasz Kalinowski
    • Tomasz Demkow
    • Olga Kuczkiewicz‑Siemion
    • Roman Romaniuk

  • View Affiliations / Copyright

    Affiliations: Department of Urogenital Cancer, Maria Skłodowska‑Curie National Research Institute of Oncology, 02‑781 Warsaw, Poland, Department of Pathology and Laboratory Diagnostics, Maria Skłodowska‑Curie National Research Institute of Oncology, 02‑781 Warsaw, Poland
    Copyright: © Kalinowski et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 91
    |
    Published online on: December 31, 2025
       https://doi.org/10.3892/ol.2025.15444
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Abstract

Urothelial carcinoma accounts for the vast majority of diagnosed bladder cancer cases. Urothelial carcinoma is prone to recurrence and metastasis despite complete resection of the lesions. The present case report describes a patient who underwent cystoprostatectomy due to a diagnosis of recurrent bladder cancer, with a penile lesion found several years after surgery. A partial penectomy was performed and the subsequent histopathology result showed urothelial carcinoma of the urethra and the epithelium of the glans and foreskin nested by micturition. The present case is an extremely rare incidence of the spread of cancer through the urine. To date, only a few such cases have been reported in the literature.
View Figures

Figure 1

Typical high grade urothelial carcinoma morphology. (A) Neoplasm with papillary configuration and architectural disorder, enlarged pleomorphic oval shaped hyperchromatic nuclei, with prominent nucleoli and frequent mitotic figures; black arrow (hematoxylin and eosin stain; magnification, ×200). (B) Gland penis with visible border between high grade urothelial carcinoma of the external meatus of the urethra (black arrow) and implantation of urothelial carcinoma within squamous epithelium (white arrow) (hematoxylin and eosin stain; magnification, ×20). (C) Visible border between non-invasive high grade urothelial carcinoma of the urethra and normal squamous epithelium of the glans penis (black arrow). Further within the epithelium, morphologically identical urothelial carcinoma was observed replacing normal squamous epithelium of the glans penis surface (white arrow). There is no direct connection between the urethral carcinoma and the glans penis surface (hematoxylin and eosin stain; magnification ×40).

Figure 2

(A) Strong nuclear GATA binding protein 3 staining in the urethral tumor, with negative staining in the normal squamous epithelium of the glans penis (magnification, ×100). (B) Cytoplasmic cytokeratin 7 staining in the urethral tumor, with negative staining in the normal squamous epithelium of the glans penis (magnification, ×100).

Figure 3

(A) Positive S100 calcium binding protein P (nuclear) staining in majority of tumor cells (magnification, ×200). (B) Negative p16 staining in all tumor cells, compared with normal squamous epithelium (magnification, ×100).

Figure 4

(A) Negative cytokeratin 20 staining in tumor cells and normal squamous epithelium (magnification, ×40). (B) Upregulation of p53 in urothelial carcinoma (magnification, ×100). (C) High proliferation index indicated by Ki-67 staining in tumor cells compared with normal squamous epithelium (magnification, ×40).
View References

1 

van der Heijden AG, Bruins HM, Carrion A, Cathomas R, Compérat E, Dimitropoulos K, Efstathiou JA, Fietkau R, Kailavasan M, Lorch A, et al: EAU Guidelines on Muscle-invasive and Metastatic Bladder Cancer. European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2025 Guidelines. Eur Urol. 87:582–600. 2025. View Article : Google Scholar : PubMed/NCBI

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018.PubMed/NCBI

3 

Chavan S, Bray F, Lortet-Tieulent J, Goodman M and Jemal A: International variations in bladder cancer incidence and mortality. Eur Urol. 66:59–73. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Mari A, Campi R, Tellini R, Gandaglia G, Albisinni S, Abufaraj M, Hatzichristodoulou G, Montorsi F, van Velthoven R, Carini M, et al: Patterns and predictors of recurrence after open radical cystectomy for bladder cancer: A comprehensive review of the literature. World J Urol. 36:157–170. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Polanco-Pujol L, Caño-Velasco J, Moralejo-Garate M, Bataller-Monfort V, Subirá-Ríos D and Hernández FC: Penile metastasis from urothelial carcinoma: Review of literature. Arch Esp Urol. 74:208–214. 2021.PubMed/NCBI

6 

Yu T, Cui X, Liang N, Wu S and Lin C: Postoperative metachronous metastasis of bladder cancer to penis: A case report. Arch Esp Urol. 76:622–626. 2023. View Article : Google Scholar : PubMed/NCBI

7 

Sönmez NC, Coşkun B, Arisan S, Güney S and Dalkılıç A: Early penile metastasis from primary bladder cancer as the first systemic manifestation: A case report. Cases J. 2:72812009. View Article : Google Scholar : PubMed/NCBI

8 

Brierley JD, Gospodarowicz MK and Wittekind C: TNM Classification of Malignant Tumours. 8th edition. John Wiley & Sons Ltd.; Oxford: 2017

9 

Guvel S, Kilinc F, Torun D, Egilmez T and Ozkardes H: Malignant priapism secondary to bladder cancer. J Androl. 24:499–500. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Weeratunga GN: Cutaneous metastatic implantation of ureteric urothelial carcinoma to the glans and prepuce. Urol Case Rep. 47:1023392023.PubMed/NCBI

11 

Ogiso S, Maeno A, Yamashita M, Souma T, Nakamura K and Okuno H: Micturitional disturbance due to labial adhesion as a cause of vaginal implantation of bladder urothelial carcinoma. Int J Urol. 13:1454–1455. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Makino T, Kitagawa Y and Namiki M: Metastatic urothelial carcinoma of the prepuce and glans penis: Suspected implantation of non-muscle-invasive bladder cancer via urine. Case Rep Oncol. 7:509–512. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Miyamoto T, Ikehara A, Araki M, Akaeda T and Mihara M: Cutaneous metastatic carcinoma of the penis: Suspected metastasis implantation from a bladder tumor. J Urol. 163:15192000. View Article : Google Scholar : PubMed/NCBI

14 

European Association of Urology (EAU), . ASCO Guidelines on Penile Cancer. EAU Central Office; Arnhem: 2025, https://uroweb.org/guidelines/penile-cancerAugust 8–2025

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Copy and paste a formatted citation
Spandidos Publications style
Kalinowski P, Nalej P, Grochulska‑Nalazek B, Kalinowski T, Demkow T, Kuczkiewicz‑Siemion O and Romaniuk R: Metastatic urothelial carcinoma of the urethra and glans penis with reported implantation via the urine: A case report. Oncol Lett 31: 91, 2026.
APA
Kalinowski, P., Nalej, P., Grochulska‑Nalazek, B., Kalinowski, T., Demkow, T., Kuczkiewicz‑Siemion, O., & Romaniuk, R. (2026). Metastatic urothelial carcinoma of the urethra and glans penis with reported implantation via the urine: A case report. Oncology Letters, 31, 91. https://doi.org/10.3892/ol.2025.15444
MLA
Kalinowski, P., Nalej, P., Grochulska‑Nalazek, B., Kalinowski, T., Demkow, T., Kuczkiewicz‑Siemion, O., Romaniuk, R."Metastatic urothelial carcinoma of the urethra and glans penis with reported implantation via the urine: A case report". Oncology Letters 31.2 (2026): 91.
Chicago
Kalinowski, P., Nalej, P., Grochulska‑Nalazek, B., Kalinowski, T., Demkow, T., Kuczkiewicz‑Siemion, O., Romaniuk, R."Metastatic urothelial carcinoma of the urethra and glans penis with reported implantation via the urine: A case report". Oncology Letters 31, no. 2 (2026): 91. https://doi.org/10.3892/ol.2025.15444
Copy and paste a formatted citation
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Spandidos Publications style
Kalinowski P, Nalej P, Grochulska‑Nalazek B, Kalinowski T, Demkow T, Kuczkiewicz‑Siemion O and Romaniuk R: Metastatic urothelial carcinoma of the urethra and glans penis with reported implantation via the urine: A case report. Oncol Lett 31: 91, 2026.
APA
Kalinowski, P., Nalej, P., Grochulska‑Nalazek, B., Kalinowski, T., Demkow, T., Kuczkiewicz‑Siemion, O., & Romaniuk, R. (2026). Metastatic urothelial carcinoma of the urethra and glans penis with reported implantation via the urine: A case report. Oncology Letters, 31, 91. https://doi.org/10.3892/ol.2025.15444
MLA
Kalinowski, P., Nalej, P., Grochulska‑Nalazek, B., Kalinowski, T., Demkow, T., Kuczkiewicz‑Siemion, O., Romaniuk, R."Metastatic urothelial carcinoma of the urethra and glans penis with reported implantation via the urine: A case report". Oncology Letters 31.2 (2026): 91.
Chicago
Kalinowski, P., Nalej, P., Grochulska‑Nalazek, B., Kalinowski, T., Demkow, T., Kuczkiewicz‑Siemion, O., Romaniuk, R."Metastatic urothelial carcinoma of the urethra and glans penis with reported implantation via the urine: A case report". Oncology Letters 31, no. 2 (2026): 91. https://doi.org/10.3892/ol.2025.15444
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