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Meta‑analysis of the clinical efficacy of anti‑PD‑1/L1 + paclitaxel/albumin‑paclitaxel + platinum vs. paclitaxel/albumin‑paclitaxel + platinum in the treatment of patients with advanced non‑small cell lung cancer

  • Authors:
    • Feng Li
    • Suyun Yan
    • Liping Liu
  • View Affiliations / Copyright

    Affiliations: Intensive Care Unit, Zibo Wanjie Cancer Hospital, Zibo, Shandong 255200, P.R. China, Department of Oncology, Zibo Wanjie Cancer Hospital, Zibo, Shandong 255200, P.R. China, Department of Oncology, Qingdao Endocrine and Diabetes Hospital, Qingdao, Shandong 266000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 101
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    Published online on: January 9, 2026
       https://doi.org/10.3892/ol.2026.15454
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Abstract

Platinum‑based dual‑drug chemotherapy is the standard first‑line treatment for non‑small cell lung cancer. It inhibits tumor proliferation through cytotoxic effects. However, in clinical practice, 30‑40% of patients will experience disease progression due to primary or secondary drug resistance. The present study aimed to analyze the clinical efficacy and adverse reactions of anti‑PD‑1/L1 + paclitaxel/albumin‑paclitaxel + platinum and paclitaxel/albumin‑paclitaxel + platinum in the treatment of advanced non‑small cell lung cancer. Computer searches were conducted in PubMed, The Cochrane Library, EMbase, China National Knowledge Infrastructure, Wanfang Data, VIPernet and China Biology Medicine databases. Randomized controlled trials on the clinical efficacy of taxel/albumin‑paclitaxel + platinum and the combination of taxel/albumin‑paclitaxel + platinum immunotherapy drugs in patients with non‑small cell lung cancer were collected from the establishment of the database to May 2025. Meta‑analysis was conducted using RevMan 5.4 software. A total of five randomized controlled trials were included, involving a total of 3,683 patients. The meta‑analysis showed that the median survival rate and the incidence of asymptomatic recurrence in the experimental group (anti‑PD‑1/L1 + paclitaxel/albumin‑paclitaxel + platinum combined immunotherapy drugs) for the treatment of non‑small cell lung cancer were higher than those in the control group (paclitaxel/albumin‑paclitaxel + platinum). The median progression‑free and overall survival time in the experimental group were longer than those in the control group, and the incidence of side effects was higher than that in the control group. The experimental group had advantages in treating non‑small cell lung cancer during the asymptomatic remission period and prolonging survival time, but the incidence of adverse reactions decreased.

View Figures

Figure 1

Literature screening process.

Figure 2

Risk of bias map. RCT, randomized
control trial.

Figure 3

Forest plot of the median overall
survival rate of patients with non-small cell lung cancer. There
was no statistical heterogeneity among the studies (P=0.07,
I2=49). A random-effects model was used for
meta-analysis; overall survival of the T group was significantly
higher than that of the C group [OR=20.43, 95%CI (18.81, 22.19),
P<0.001]. C, control; T, test;-HR, Hazard Ratio; df, degrees of
freedom; IV, Information Value; CI, confidence interval.

Figure 4

Forest plots of the median
asymptomatic survival of patients with non-small cell lung cancer.
There was no statistical heterogeneity among the studies (P=0.14,
I2=38). A random-effects model was used for
meta-analysis; asymptomatic survival of the T group was
significantly higher than that of the C group [OR=7.24, 95%CI
(6.93, 7.78), P<0.001]. C, control group; T, the test group; HR,
Hazard Ratio; df, degrees of freedom; IV, Information Value; CI,
confidence interval.

Figure 5

Forest plots of the occurrence of
adverse reactions in patients with non-small cell lung cancer.
There was no statistical heterogeneity among the studies
(P<0.00001, I2=84). A random-effects model was used
for meta-analysis; incidence of adverse events in the T group was
significantly lower than that in the C group [OR=2.47, 95%CI (1.16,
5.25), P=0.02]. C, control; T, test; OR, odds ratio; df, degrees of
freedom; IV, Information Value; CI, confidence interval.
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Copy and paste a formatted citation
Spandidos Publications style
Li F, Yan S and Liu L: <p>Meta‑analysis of the clinical efficacy of anti‑PD‑1/L1 + paclitaxel/albumin‑paclitaxel + platinum vs. paclitaxel/albumin‑paclitaxel + platinum in the treatment of patients with advanced non‑small cell lung cancer</p>. Oncol Lett 31: 101, 2026.
APA
Li, F., Yan, S., & Liu, L. (2026). <p>Meta‑analysis of the clinical efficacy of anti‑PD‑1/L1 + paclitaxel/albumin‑paclitaxel + platinum vs. paclitaxel/albumin‑paclitaxel + platinum in the treatment of patients with advanced non‑small cell lung cancer</p>. Oncology Letters, 31, 101. https://doi.org/10.3892/ol.2026.15454
MLA
Li, F., Yan, S., Liu, L."<p>Meta‑analysis of the clinical efficacy of anti‑PD‑1/L1 + paclitaxel/albumin‑paclitaxel + platinum vs. paclitaxel/albumin‑paclitaxel + platinum in the treatment of patients with advanced non‑small cell lung cancer</p>". Oncology Letters 31.3 (2026): 101.
Chicago
Li, F., Yan, S., Liu, L."<p>Meta‑analysis of the clinical efficacy of anti‑PD‑1/L1 + paclitaxel/albumin‑paclitaxel + platinum vs. paclitaxel/albumin‑paclitaxel + platinum in the treatment of patients with advanced non‑small cell lung cancer</p>". Oncology Letters 31, no. 3 (2026): 101. https://doi.org/10.3892/ol.2026.15454
Copy and paste a formatted citation
x
Spandidos Publications style
Li F, Yan S and Liu L: <p>Meta‑analysis of the clinical efficacy of anti‑PD‑1/L1 + paclitaxel/albumin‑paclitaxel + platinum vs. paclitaxel/albumin‑paclitaxel + platinum in the treatment of patients with advanced non‑small cell lung cancer</p>. Oncol Lett 31: 101, 2026.
APA
Li, F., Yan, S., & Liu, L. (2026). <p>Meta‑analysis of the clinical efficacy of anti‑PD‑1/L1 + paclitaxel/albumin‑paclitaxel + platinum vs. paclitaxel/albumin‑paclitaxel + platinum in the treatment of patients with advanced non‑small cell lung cancer</p>. Oncology Letters, 31, 101. https://doi.org/10.3892/ol.2026.15454
MLA
Li, F., Yan, S., Liu, L."<p>Meta‑analysis of the clinical efficacy of anti‑PD‑1/L1 + paclitaxel/albumin‑paclitaxel + platinum vs. paclitaxel/albumin‑paclitaxel + platinum in the treatment of patients with advanced non‑small cell lung cancer</p>". Oncology Letters 31.3 (2026): 101.
Chicago
Li, F., Yan, S., Liu, L."<p>Meta‑analysis of the clinical efficacy of anti‑PD‑1/L1 + paclitaxel/albumin‑paclitaxel + platinum vs. paclitaxel/albumin‑paclitaxel + platinum in the treatment of patients with advanced non‑small cell lung cancer</p>". Oncology Letters 31, no. 3 (2026): 101. https://doi.org/10.3892/ol.2026.15454
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