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LINC00473 modulates protein expression to promote ovarian cancer progression and overcome cisplatin resistance

  • Authors:
    • Cairong Zhang
    • Jie Ma
    • Wenling Wang
    • Min Guo
    • Cuiliu Han
    • Madinamu Sadike
    • Kaichun Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, People's Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, Xinjiang Uygur Autonomous Region 830000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 103
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    Published online on: January 12, 2026
       https://doi.org/10.3892/ol.2026.15456
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Abstract

The present study aimed to systematically investigate the biological role of the long non‑coding RNA (lncRNA) LINC00473 in the pathogenesis and progression of ovarian cancer and to explore its potential as a novel therapeutic target for clinical translation. LINC00473 expression was specifically silenced in SK‑OV‑3 and A2780 ovarian cancer cell lines using small interfering RNA technology. Enhanced Cell Counting Kit‑8 and Transwell invasion assays were performed to evaluate the regulatory effects of LINC00473 on malignant phenotypes (proliferation, migration, invasion and apoptosis) and chemosensitivity to cisplatin (CDDP). Western blotting was utilized to detect changes in the expression levels of apoptosis‑related proteins [poly (adenosine diphosphate‑ribose) polymerase (PARP) and caspase‑3] and stemness/drug resistance‑associated proteins [Sox2 and Yes‑associated protein 1 (YAP1)]. Knockdown of LINC00473 significantly inhibited ovarian cancer cell proliferation (SK‑OV‑3, 23.1%, P<0.001; A2780, 41.5%, P<0.001) and induced apoptosis (apoptosis rate 18.0‑25.2%; P<0.001), while reducing migration and invasion by 30.7‑55.4% and 31.9‑54.5% (both P<0.001), respectively, accompanied by pseudopodia retraction and cellular rounding. At the molecular level, LINC00473 knockdown upregulated PARP/caspase‑3 expression (1.7‑ and 2.3‑fold) and downregulated Sox2/YAP1 (0.5‑ and 0.6‑fold), with A2780 cells exhibiting 25% higher sensitivity to intervention compared with SK‑OV‑3 cells. Combined with CDDP treatment, the proliferation rate of A2780 further decreased to 35.5% (P<0.001)‌. These findings indicate that LINC00473 may promote ovarian cancer progression by suppressing apoptosis and activating oncogenic pathways (Sox2/YAP1)‌. Furthermore, silencing LINC00473 synergistically enhanced CDDP efficacy, particularly in A2780 cells exhibiting heightened sensitivity‌. These findings suggest that targeting LINC00473 may represent a novel therapeutic strategy for ovarian cancer; however further exploration of its molecular network and in vivo validation are warranted in the future‌.
View Figures

Figure 1

LINC00473 knockdown efficiency in
ovarian cancer cell lines. Quantitative analysis of LINC00473
expression in (A) SK-OV-3 and (B) A2780 cells after transfection
with siLINC00473, compared with siNC and untreated controls. Data
are presented as the mean±SD. ***P<0.001. LINC, long non-coding
RNA; NC, negative control; si, small interfering RNA.

Figure 2

Silencing LINC00473 significantly
inhibits cell proliferation and induces apoptosis. Proliferation of
(A) SK-OV-3 and (B) A2780 cells after transfection with
siLINC00473, siNC and untreated controls (C). Proliferation
inhibition rates of both cell lines post-transfection. Apoptosis
status of (D) SK-OV-3 and (E) A2780 cells. Data are presented as
the mean±SD. ***P<0.001. LINC, long non-coding RNA; NC, negative
control; si, small interfering RNA.

Figure 3

Cell migration and invasion after
siLINC00473 transfection. Transfection of siLINC00473 markedly
reduced both (A-C) migration and (D-F) invasion of ovarian cancer
cells compared with those transfected with siNC. Representative
crystal violet-stained microscopic images (×200 magnification)
illustrate the (A) migrated and (D) invaded cells, with
quantitative analyses confirming statistically significant
inhibition of (B and C) migration and (E and F) invasion. Data are
presented as mean±SD; ***P<0.001. LINC, long non-coding RNA; NC,
negative control; si, small interfering RNA.

Figure 4

Cellular protein expression after
siLINC00473 transfection. (A) Differential expression patterns of
five proteins in two ovarian cancer cell lines after transfection
with siLINC00473 vs. the scrambled siNC. Semi-quantitative analysis
of relative expression levels of (B) PARP, (C) caspase-3, (D) Sox2
and (E) YAP1 normalized to GAPDH, demonstrating significant
downregulation in siLINC00473-treated cells compared with siNC.
Data are presented as the mean±SD; ***P<0.001. LINC, long
non-coding RNA; NC, negative control; PARP, poly (adenosine
diphosphate-ribose) polymerase; si, small interfering RNA; YAP1,
yes-associated protein 1.

Figure 5

Effect of siLINC00473 transfection on
cellular sensitivity to CDDP. Comparison of cellular sensitivity to
CDDP after transfection of (A) SK-OV-3 and (B) A2780 cells with
siLINC00473, compared with the siNC group and the blank control
group. ***P<0.001. LINC, long non-coding RNA; CDDP, cisplatin;
NC, negative control; si, small interfering RNA.
View References

1 

Siegel RL, Miller KD, Wagle NS and Jemal A: Cancer statistics, 2023. CA Cancer J Clin. 73:17–48. 2023.PubMed/NCBI

2 

Lheureux S, Braunstein M and Oza AM: Epithelial ovarian cancer: Evolution of management in the era of precision medicine. CA Cancer J Clin. 69:280–304. 2019.PubMed/NCBI

3 

Bhan A, Soleimani M and Mandal SS: Long noncoding RNA and cancer: A new paradigm. Cancer Res. 77:3965–3981. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Zhang X, Wang W, Zhu W, Dong J, Cheng Y, Yin Z and Shen F: Mechanisms and functions of long non-coding RNAs at multiple regulatory levels. Int J Mol Sci. 20:55732019. View Article : Google Scholar : PubMed/NCBI

5 

Slack FJ and Chinnaiyan AM: The Role of non-coding RNAs in oncology. Cell. 179:1033–1055. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Li L, Zhang X, Liu N, Chen X and Peng C: LINC00473: A novel oncogenic long noncoding RNA in human cancers. J Cell Physiol. 236:4174–4183. 2021. View Article : Google Scholar : PubMed/NCBI

7 

Yang WZ, Zhou H and Yan Y: XIAP underlies apoptosis resistance of renal cell carcinoma cells. Mol Med Rep. 17:125–130. 2018.PubMed/NCBI

8 

Yang L, Xie HJ, Li YY, Wang X, Liu XX and Mai J: Molecular mechanisms of platinum-based chemotherapy resistance in ovarian cancer (review). Oncol Rep. 47:822022. View Article : Google Scholar : PubMed/NCBI

9 

Zanconato F, Cordenonsi M and Piccolo S: YAP/TAZ at the roots of cancer. Cancer Cell. 29:783–803. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Chen Y, Li Z, Chen X and Zhang S: Long non-coding RNAs: From disease code to drug role. Acta Pharm Sin B. 11:340–354. 2021. View Article : Google Scholar : PubMed/NCBI

11 

Mo J, Li B, Zhou Y, Xu Y, Jiang H, Cheng X, Wu X and Zhang Y: LINC00473 promotes hepatocellular carcinoma progression via acting as a ceRNA for microRNA-195 and increasing HMGA2 expression. Biomed Pharmacother. 120:1094032019. View Article : Google Scholar : PubMed/NCBI

12 

Wang JY, Lu AQ and Chen LJ: LncRNAs in ovarian cancer. Clin Chim Acta. 490:17–27. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Shankaraiah RC, Veronese A, Sabbioni S and Negrini M: Non-coding RNAs in the reprogramming of glucose metabolism in cancer. Cancer Lett. 419:167–174. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Leeper NJ and Maegdefessel L: Non-coding RNAs: Key regulators of smooth muscle cell fate in vascular disease. Cardiovasc Res. 114:611–621. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Zhang Q, Wang G, Xu L, Yao Z and Song L: Long non-coding RNA LINC00473 promotes glioma cells proliferation and invasion by impairing miR-637/CDK6 axis. Artif Cells Nanomed Biotechnol. 47:3896–3903. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Zhu S, Fu W, Zhang L, Fu K, Hu J, Jia W and Liu G: LINC00473 antagonizes the tumour suppressor miR-195 to mediate the pathogenesis of Wilms tumour via IKKα. Cell Prolif. 51:e124162018. View Article : Google Scholar : PubMed/NCBI

18 

Wang H, Gao L, Chen Y, Zhang L, Bai Y, Zhao C, Zhang L, Zuo L and Sun H: Identification of hub genes in bladder transitional cell carcinoma through ceRNA network construction integrated with gene network analysis. J Cell Mol Med. 28:e179792024. View Article : Google Scholar : PubMed/NCBI

19 

Li J, Qian Y, Zhang C, Wang W, Qiao Y, Song H, Li L, Guo J, Lu D and Deng X: LncRNA LINC00473 is involved in the progression of invasive pituitary adenoma by upregulating KMT5A via ceRNA-mediated miR-502-3p evasion. Cell Death Dis. 12:5802021. View Article : Google Scholar : PubMed/NCBI

20 

Zhang C and Yang T: Long Non-coding RNA LINC00473 promotes breast cancer progression via miR-424-5p/CCNE1 pathway. Protein Pept Lett. 30:72–84. 2023. View Article : Google Scholar : PubMed/NCBI

21 

Xu SH, Bo YH, Ma HC, Zhang HN and Shao MJ: lncRNA LINC00473 promotes proliferation, migration, invasion and inhibition of apoptosis of non-small cell lung cancer cells by acting as a sponge of miR-497-5p. Oncol Lett. 21:4292021. View Article : Google Scholar : PubMed/NCBI

22 

Xu Y, Jiang Y, Wang Y, Zhao Z and Li T: LINC00473 rescues human bone marrow mesenchymal stem cells from apoptosis induced by dexamethasone through the PEBP1-mediated Akt/Bad/Bcl-2 signaling pathway. Int J Mol Med. 47:171–182. 2021. View Article : Google Scholar : PubMed/NCBI

23 

Yeung K, Seitz T, Li S, Janosch P, McFerran B, Kaiser C, Fee F, Katsanakis KD, Rose DW, Mischak H, et al: Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Nature. 401:173–177. 1999. View Article : Google Scholar : PubMed/NCBI

24 

Noh HS, Hah YS, Zada S, Ha JH, Sim G, Hwang JS, Lai TH, Nguyen HQ, Park JY, Kim HJ, et al: PEBP1, a RAF kinase inhibitory protein, negatively regulates starvation-induced autophagy by direct interaction with LC3. Autophagy. 12:2183–2196. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Zhang Y, Song X, Wang X, Hu J and Jiang L: Silencing of LncRNA HULC enhances chemotherapy induced apoptosis in human gastric cancer. J Med Biochem. 35:137–143. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Zhou Y, Zhang Y, Shao Y, Yue X, Chu Y, Yang C and Chen D: LncRNA HOTAIR down-expression inhibits the invasion and tumorigenicity of epithelial ovarian cancer cells by suppressing TGF-β1 and ZEB1. Discov Oncol. 14:2282023. View Article : Google Scholar : PubMed/NCBI

27 

Casagrande N, Borghese C, Agostini F, Durante C, Mazzucato M, Colombatti A and Aldinucci D: In ovarian cancer multicellular spheroids, platelet releasate promotes growth, expansion of ALDH+ and CD133+ cancer stem cells, and protection against the cytotoxic effects of cisplatin, carboplatin and paclitaxel. Int J Mol Sci. 22:30192021. View Article : Google Scholar : PubMed/NCBI

28 

Ma N, Zhang M, Hu J, Wei Z and Zhang S: Daphnetin induces ferroptosis in ovarian cancer by inhibiting NAD(P)H:Quinone oxidoreductase 1 (NQO1). Phytomedicine. 132:1558762024. View Article : Google Scholar : PubMed/NCBI

29 

Wojtowicz K and Nowicki M: The characterization of the sensitive ovarian cancer cell lines A2780 and W1 in response to ovarian CAFs. Biochem Biophys Res Commun. 662:1–7. 2023. View Article : Google Scholar : PubMed/NCBI

30 

Li X, Guo Y, Xing Z, Gong T, Yang L, Yang T, Chang B, Wang X, Yu B and Guo R: ABT-737 increases cisplatin sensitivity through the ROS-ASK1-JNK MAPK signaling axis in human ovarian cancer cisplatin-resistant A2780/DDP cells. Oncol Rep. 52:1222024. View Article : Google Scholar : PubMed/NCBI

31 

Wang DY, Li N and Cui YL: Long non-coding RNA CCAT1 sponges miR-454 to promote chemoresistance of ovarian cancer cells to cisplatin by regulation of surviving. Cancer Res Treat. 52:798–814. 2020. View Article : Google Scholar : PubMed/NCBI

32 

Wang B, Liu M, Zhuang R, Jiang J, Gao J, Wang H, Chen H, Zhang Z, Kuang Y and Li P: Long non-coding RNA CCAT2 promotes epithelial-mesenchymal transition involving Wnt/β-catenin pathway in epithelial ovarian carcinoma cells. Oncol Lett. 15:3369–3375. 2018.PubMed/NCBI

33 

Wang H, Ge W, Jiang W, Li D and Ju X: SRPK1-siRNA suppresses K562 cell growth and induces apoptosis via the PARP-caspase3 pathway. Mol Med Rep. 17:2070–2076. 2018.PubMed/NCBI

34 

Li S, Lv C, Li J, Xie T, Liu X, Zheng Z, Qin Z, Hui X and Yu Y: LncRNA LINC00473 promoted colorectal cancer cell proliferation and invasion by targeting miR-195 expression. Am J Transl Res. 13:6066–6075. 2021.PubMed/NCBI

35 

Ding LN, Yu YY, Ma CJ, Lei CJ and Zhang HB: SOX2-associated signaling pathways regulate biological phenotypes of cancers. Biomed Pharmacother. 160:1143362023. View Article : Google Scholar : PubMed/NCBI

36 

Liu C, Barger CJ and Karpf AR: FOXM1: A multifunctional oncoprotein and emerging therapeutic target in ovarian cancer. Cancers (Basel). 13:30652021. View Article : Google Scholar : PubMed/NCBI

37 

Disis ML, Taylor MH, Kelly K, Beck JT, Gordon M, Moore KM, Patel MR, Chaves J, Park H, Mita AC, et al: Efficacy and safety of Avelumab for patients with recurrent or refractory ovarian cancer: Phase 1b results from the JAVELIN solid tumor trial. JAMA Oncol. 5:393–401. 2019. View Article : Google Scholar : PubMed/NCBI

38 

Fu Y, Zhang Y, Cui J, Yang G, Peng S, Mi W, Yin X, Yu Y, Jiang J, Liu Q, et al: SNP rs12982687 affects binding capacity of lncRNA UCA1 with miR-873-5p: involvement in smoking-triggered colorectal cancer progression. Cell Commun Signal. 18:372020. View Article : Google Scholar : PubMed/NCBI

39 

Wang X, Zhang H, Yin S, Yang Y, Yang H, Yang J, Zhou Z, Li S, Ying G and Ba Y: lncRNA-encoded pep-AP attenuates the pentose phosphate pathway and sensitizes colorectal cancer cells to oxaliplatin. EMBO Rep. 23:e531402022. View Article : Google Scholar : PubMed/NCBI

40 

Jiang J, Wang S, Wang Z, Cai J, Han L, Xie L, Han Q, Wang W, Zhang Y, He X and Yang C: HOTAIR promotes paclitaxel resistance by regulating CHEK1 in ovarian cancer. Cancer Chemother Pharmacol. 86:295–305. 2020. View Article : Google Scholar : PubMed/NCBI

41 

Kielbik M, Szulc-Kielbik I and Klink M: Impact of selected signaling proteins on SNAIL 1 and SNAIL 2 expression in ovarian cancer cell lines in relation to cells' cisplatin resistance and EMT markers level. Int J Mol Sci. 22:9802021. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang C, Ma J, Wang W, Guo M, Han C, Sadike M and Zhu K: LINC00473 modulates protein expression to promote ovarian cancer progression and overcome cisplatin resistance. Oncol Lett 31: 103, 2026.
APA
Zhang, C., Ma, J., Wang, W., Guo, M., Han, C., Sadike, M., & Zhu, K. (2026). LINC00473 modulates protein expression to promote ovarian cancer progression and overcome cisplatin resistance. Oncology Letters, 31, 103. https://doi.org/10.3892/ol.2026.15456
MLA
Zhang, C., Ma, J., Wang, W., Guo, M., Han, C., Sadike, M., Zhu, K."LINC00473 modulates protein expression to promote ovarian cancer progression and overcome cisplatin resistance". Oncology Letters 31.3 (2026): 103.
Chicago
Zhang, C., Ma, J., Wang, W., Guo, M., Han, C., Sadike, M., Zhu, K."LINC00473 modulates protein expression to promote ovarian cancer progression and overcome cisplatin resistance". Oncology Letters 31, no. 3 (2026): 103. https://doi.org/10.3892/ol.2026.15456
Copy and paste a formatted citation
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Spandidos Publications style
Zhang C, Ma J, Wang W, Guo M, Han C, Sadike M and Zhu K: LINC00473 modulates protein expression to promote ovarian cancer progression and overcome cisplatin resistance. Oncol Lett 31: 103, 2026.
APA
Zhang, C., Ma, J., Wang, W., Guo, M., Han, C., Sadike, M., & Zhu, K. (2026). LINC00473 modulates protein expression to promote ovarian cancer progression and overcome cisplatin resistance. Oncology Letters, 31, 103. https://doi.org/10.3892/ol.2026.15456
MLA
Zhang, C., Ma, J., Wang, W., Guo, M., Han, C., Sadike, M., Zhu, K."LINC00473 modulates protein expression to promote ovarian cancer progression and overcome cisplatin resistance". Oncology Letters 31.3 (2026): 103.
Chicago
Zhang, C., Ma, J., Wang, W., Guo, M., Han, C., Sadike, M., Zhu, K."LINC00473 modulates protein expression to promote ovarian cancer progression and overcome cisplatin resistance". Oncology Letters 31, no. 3 (2026): 103. https://doi.org/10.3892/ol.2026.15456
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