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Endostar combined with docetaxel or cisplatin in the management of malignant ascites through hyperthermic intraperitoneal chemotherapy: A retrospective cohort study

  • Authors:
    • Jing Wu
    • Dashan Yin
    • Jin Qian
    • Yi Zhou
    • Yajun Wu
    • Ganlu Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Zhejiang Hospital, Hangzhou, Zhejiang 310030, P.R. China, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China, The Second School of Clinical Medical, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China, Department of Traditional Chinese Medicine Pharmacy, Zhejiang Hospital, Hangzhou, Zhejiang 310030, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 111
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    Published online on: January 14, 2026
       https://doi.org/10.3892/ol.2026.15463
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Abstract

Peritoneal metastases (PM) are a prevalent and treatment‑resistant form of recurrence in patients with abdominal tumors. The present study retrospectively examined the clinical performance and potential adverse effects of combining Endostar with docetaxel/cisplatin chemotherapeutic hyperthermic intraperitoneal chemotherapy (HIPEC) for treating malignant ascites (MA). Subjects diagnosed with malignancies confirmed by ascites cell block results and clinical presentations were included within the study, constituting a total of 48 MA cases. The docetaxel group (n=25) was treated with Endostar combined with docetaxel for two cycles. The cisplatin group (n=23) was treated with Endostar combined with cisplatin for two cycles. The objective response rate (ORR; defined as CR + PR), disease control rate (DCR; defined as CR + PR + SD), ascites control time, improvement rate of the Karnofsky Performance Status (KPS) and incidence of major adverse reactions were statistically analyzed. There were no significant differences in the ORR (64.0 vs. 56.5%), DCR (92.0 vs. 91.3%), improvement rate of KPS (48.0 vs. 43.5%) or ascites control time (55 vs. 46 days) between the docetaxel and cisplatin groups (all P>0.05). Renal function impairment developed in 7 patients (30.4%) in the cisplatin group compared with 1 patient (4.0%) in the docetaxel group (P<0.05). Except for renal injury and blood pressure, there were no statistically significant differences in the incidences of other adverse reactions or treatment‑related deaths between the two groups. Overall, the combined application of Endostar and docetaxel/cisplatin HIPEC yielded promising clinical outcomes in the treatment of MA, as indicated by high ORRs and DCRs, significantly improving the quality of life for affected individuals. However, it is worth noting that the incidence of nephrotoxicity was higher in the cisplatin treatment group compared with that in the docetaxel treatment group. Therefore, clinicians should be cautious about nephrotoxicity when administering cisplatin in high‑risk patients with PM.

View Figures

Figure 1

Schematic diagram of
docetaxel/cisplatin HIPEC combined with IP Endostar. Point 1:
Endostar was injected intraperitoneally. Point 2: Docetaxel or
cisplatin was heated and circulated. A thermometer was placed in
the rectum to monitor the patient's temperature. IP,
intraperitoneal; HIPEC, hyperthermic IP chemotherapy.

Figure 2

Process scheme of the study. A total
of 48 patients were included for the final analysis, including 16
patients with gastric cancer, 14 patients with colorectal cancer,
13 patients with ovarian cancer and 5 patients with pancreatic
cancer. IP, intraperitoneal; HIPEC, hyperthermic IP chemotherapy;
KPS, Karnofsky Performance Status.

Figure 3

Comparison of ascites control between
the two groups of patients.

Figure 4

Mechanisms of docetaxel/cisplatin
HIPEC combined with IP Endostar in the treatment of MA. As shown in
point 1, the IP Endostar injection inhibits VEGF expression,
reduces MA and reduces vascular permeability. A shown in point 2,
when HIPEC is performed, drug concentration and temperature
increase. As shown in points 3 and 4, the addition of cisplatin can
prevent DNA replication and transcription, while the addition of
docetaxel can stabilize the aggregation of tubulin and prevent
depolymerization. MA, malignant ascites; IP, intraperitoneal;
HIPEC, hyperthermic IP chemotherapy; FCC, free cancer cell. Created
in BioRender, https://app.biorender.com/illustrations/64297f7a20eede8ed30124a8?slideId=3d6d849d-02c8-4b18-b5ee-18396b8d452e.
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Spandidos Publications style
Wu J, Yin D, Qian J, Zhou Y, Wu Y and Zhang G: <p>Endostar combined with docetaxel or cisplatin in the management of malignant ascites through hyperthermic intraperitoneal chemotherapy: A retrospective cohort study</p>. Oncol Lett 31: 111, 2026.
APA
Wu, J., Yin, D., Qian, J., Zhou, Y., Wu, Y., & Zhang, G. (2026). <p>Endostar combined with docetaxel or cisplatin in the management of malignant ascites through hyperthermic intraperitoneal chemotherapy: A retrospective cohort study</p>. Oncology Letters, 31, 111. https://doi.org/10.3892/ol.2026.15463
MLA
Wu, J., Yin, D., Qian, J., Zhou, Y., Wu, Y., Zhang, G."<p>Endostar combined with docetaxel or cisplatin in the management of malignant ascites through hyperthermic intraperitoneal chemotherapy: A retrospective cohort study</p>". Oncology Letters 31.3 (2026): 111.
Chicago
Wu, J., Yin, D., Qian, J., Zhou, Y., Wu, Y., Zhang, G."<p>Endostar combined with docetaxel or cisplatin in the management of malignant ascites through hyperthermic intraperitoneal chemotherapy: A retrospective cohort study</p>". Oncology Letters 31, no. 3 (2026): 111. https://doi.org/10.3892/ol.2026.15463
Copy and paste a formatted citation
x
Spandidos Publications style
Wu J, Yin D, Qian J, Zhou Y, Wu Y and Zhang G: <p>Endostar combined with docetaxel or cisplatin in the management of malignant ascites through hyperthermic intraperitoneal chemotherapy: A retrospective cohort study</p>. Oncol Lett 31: 111, 2026.
APA
Wu, J., Yin, D., Qian, J., Zhou, Y., Wu, Y., & Zhang, G. (2026). <p>Endostar combined with docetaxel or cisplatin in the management of malignant ascites through hyperthermic intraperitoneal chemotherapy: A retrospective cohort study</p>. Oncology Letters, 31, 111. https://doi.org/10.3892/ol.2026.15463
MLA
Wu, J., Yin, D., Qian, J., Zhou, Y., Wu, Y., Zhang, G."<p>Endostar combined with docetaxel or cisplatin in the management of malignant ascites through hyperthermic intraperitoneal chemotherapy: A retrospective cohort study</p>". Oncology Letters 31.3 (2026): 111.
Chicago
Wu, J., Yin, D., Qian, J., Zhou, Y., Wu, Y., Zhang, G."<p>Endostar combined with docetaxel or cisplatin in the management of malignant ascites through hyperthermic intraperitoneal chemotherapy: A retrospective cohort study</p>". Oncology Letters 31, no. 3 (2026): 111. https://doi.org/10.3892/ol.2026.15463
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