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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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March-2026 Volume 31 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article Open Access

Recent development on hyperthermia: An effective cotreatment improving radiotherapy outcome (Review)

  • Authors:
    • Hanyue Ying
    • Ke Zhang
    • Yu Chen
    • Qinghua Deng
    • Chun Mao
    • Jiawei Li

  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou, Zhejiang 310006, P.R China, National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, Jiangsu 210023, P.R. China
    Copyright: © Ying et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 112
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    Published online on: January 19, 2026
       https://doi.org/10.3892/ol.2026.15465
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Abstract

Tumor hyperthermia, a treatment that employs various heating techniques to elevate the temperature of tumor lesions and induce tumor cell death, has been utilized in clinical practice for nearly four decades. As an adjunct to radiotherapy and chemotherapy, hyperthermia enhances the therapeutic efficacy against both primary and recurrent tumors. The present review explores the mechanisms underlying the synergy between radiotherapy and hyperthermia, while reviewing the outcomes of relevant clinical trials. The focus is on the molecular and biological basis for the roles of hyperthermia as a radiosensitizer, as demonstrated in vitro and in vivo experiments, and on optimizing its clinical application. Key mechanisms of action include inhibition of DNA repair, reduction of hypoxic tumor cell populations, enhancement of drug uptake and improved perfusion and oxygenation. Existing randomized, non‑randomized and observational studies provide substantial evidence supporting the benefits of combining hyperthermia with radiotherapy.

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Copy and paste a formatted citation
Spandidos Publications style
Ying H, Zhang K, Chen Y, Deng Q, Mao C and Li J: <p>Recent development on hyperthermia: An effective cotreatment improving radiotherapy outcome (Review)</p>. Oncol Lett 31: 112, 2026.
APA
Ying, H., Zhang, K., Chen, Y., Deng, Q., Mao, C., & Li, J. (2026). <p>Recent development on hyperthermia: An effective cotreatment improving radiotherapy outcome (Review)</p>. Oncology Letters, 31, 112. https://doi.org/10.3892/ol.2026.15465
MLA
Ying, H., Zhang, K., Chen, Y., Deng, Q., Mao, C., Li, J."<p>Recent development on hyperthermia: An effective cotreatment improving radiotherapy outcome (Review)</p>". Oncology Letters 31.3 (2026): 112.
Chicago
Ying, H., Zhang, K., Chen, Y., Deng, Q., Mao, C., Li, J."<p>Recent development on hyperthermia: An effective cotreatment improving radiotherapy outcome (Review)</p>". Oncology Letters 31, no. 3 (2026): 112. https://doi.org/10.3892/ol.2026.15465
Copy and paste a formatted citation
x
Spandidos Publications style
Ying H, Zhang K, Chen Y, Deng Q, Mao C and Li J: <p>Recent development on hyperthermia: An effective cotreatment improving radiotherapy outcome (Review)</p>. Oncol Lett 31: 112, 2026.
APA
Ying, H., Zhang, K., Chen, Y., Deng, Q., Mao, C., & Li, J. (2026). <p>Recent development on hyperthermia: An effective cotreatment improving radiotherapy outcome (Review)</p>. Oncology Letters, 31, 112. https://doi.org/10.3892/ol.2026.15465
MLA
Ying, H., Zhang, K., Chen, Y., Deng, Q., Mao, C., Li, J."<p>Recent development on hyperthermia: An effective cotreatment improving radiotherapy outcome (Review)</p>". Oncology Letters 31.3 (2026): 112.
Chicago
Ying, H., Zhang, K., Chen, Y., Deng, Q., Mao, C., Li, J."<p>Recent development on hyperthermia: An effective cotreatment improving radiotherapy outcome (Review)</p>". Oncology Letters 31, no. 3 (2026): 112. https://doi.org/10.3892/ol.2026.15465
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