Malignant adenomyoepithelioma with <em>HRAS</em> G13R mutation:&nbsp;A case report

Kuwabara,Hiroko; Takeda,Reika; Utsumi,Yoshitaka; Nagao,Toshitaka; Kimura,Kosei; Hirose,Yoshinobu; Iwamoto,Mitsuhiko

doi:10.3892/ol.2026.15475

April-2026 Volume 31 Issue 4

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April-2026 Volume 31 Issue 4

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Case Report Open Access

Malignant adenomyoepithelioma with HRAS G13R mutation: A case report

Authors:
- Hiroko Kuwabara
- Reika Takeda
- Yoshitaka Utsumi
- Toshitaka Nagao
- Kosei Kimura
- Yoshinobu Hirose
- Mitsuhiko Iwamoto
View Affiliations / Copyright

Affiliations: Department of Pathology, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka 569‑8686, Japan, Department of Pathology, Tokyo Medical University, Tokyo 160‑8402, Japan, Department of Breast Surgery, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka 569‑8686, Japan

Copyright: © Kuwabara et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 122
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Published online on: January 30, 2026

https://doi.org/10.3892/ol.2026.15475
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Abstract

Adenomyoepithelioma (AME) of the breast is a rare tumor characterized by epithelial and myoepithelial differentiation, with a hotspot mutation in HRAS Q61. Malignant transformation occurs from either the luminal or myoepithelial component. In the present study, a malignant AME (M‑AME) with pulmonary metastasis is reported. M‑AME is rare, and the present report highlights the genomic alteration of primary and metastatic lesions. A 53‑year‑old Japanese woman presented to a neighboring clinic with a palpable and non‑tender mass in the left breast. The mass was suspected to be AME, and left mastectomy was performed at Osaka Medical and Pharmaceutical University (Takatsuki, Japan). Breast tumor specimens exhibited epithelial and myoepithelial proliferation with myoepithelial mitoses and necrosis, and the tumor was diagnosed as M‑AME. Following chemotherapy, a lung tumor was identified 2 years after the operation. The pulmonary tumor indicated myoepithelial cell proliferation along the bronchiolar epithelium, and myoepithelial cells exhibited clear or epithelioid features. Both the breast and lung tumor exhibited the HRAS G13R mutation, which is frequently observed in M‑AME. This mutation may be considered a driver mutation in mammary M‑AME.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Malignant adenomyoepithelioma with HRAS G13R mutation: A case report

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Abstract

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