|
1
|
Zhang C, Liu X, Jin S, Chen Y and Guo R:
Ferroptosis in cancer therapy: A novel approach to reversing drug
resistance. Mol Cancer. 21:472022. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Diao J, Jia Y, Dai E, Liu J, Kang R, Tang
D, Han L, Zhong Y and Meng L: Ferroptotic therapy in cancer:
Benefits, side effects, and risks. Mol Cancer. 23:892024.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Xu S, Tuo QZ, Meng J, Wu XL, Li CL and Lei
P: Thrombin induces ferroptosis in triple-negative breast cancer
through the cPLA2α/ACSL4 signaling pathway. Transl Oncol.
39:1018172024. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Kim J, Harper A, McCormack V, Sung H,
Houssami N, Morgan E, Mutebi M, Garvey G, Soerjomataram I and
Fidler-Benaoudia MM: Global patterns and trends in breast cancer
incidence and mortality across 185 countries. Nat Med.
31:1154–1162. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Xu T, Ma D, Chen S, Tang R, Yang J, Meng
C, Feng Y, Liu L, Wang J, Luo H and Yu K: High GPER expression in
triple-negative breast cancer is linked to pro-metastatic pathways
and predicts poor patient outcomes. NPJ Breast Cancer. 8:1002022.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Hsu JY, Chang CJ and Cheng JS: Survival,
treatment regimens and medical costs of women newly diagnosed with
metastatic triple-negative breast cancer. Sci Rep. 12:7292022.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Li J, He D, Li S, Xiao J and Zhu Z:
Ferroptosis: The emerging player in remodeling triple-negative
breast cancer. Front Immunol. 14:12840572023. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Raymundo DP, Doultsinos D, Guillory X,
Carlesso A, Eriksson LA and Chevet E: Pharmacological targeting of
IRE1 in cancer. Trends Cancer. 6:1018–1030. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Unal B, Kuzu OF, Jin Y, Osorio D, Kildal
W, Pradhan M, Kung SHY, Oo HZ, Daugaard M, Vendelbo M, et al:
Targeting IRE1alpha reprograms the tumor microenvironment and
enhances anti-tumor immunity in prostate cancer. Nat Commun.
15:88952024. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Shi M, Chai Y, Zhang J and Chen X:
Endoplasmic reticulum Stress-associated neuronal death and innate
immune response in neurological diseases. Front Immunol.
12:7945802021. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Jiang D, Guo Y, Wang T, Wang L, Yan Y, Xia
L, Bam R, Yang Z, Lee H, Iwawaki T, et al: IRE1α determines
ferroptosis sensitivity through regulation of glutathione
synthesis. Nat Commun. 15:41142024. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Zheng X, Wei J, Li W, Li X, Wang W, Guo J
and Fu Z: PRDX2 removal inhibits the cell cycle and autophagy in
colorectal cancer cells. Aging (Albany NY). 12:16390–16409. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Jiao L, Li X, Luo Y, Wei J, Ding X, Xiong
H, Liu X and Lei P: Iron metabolism mediates microglia
susceptibility in ferroptosis. Front Cell Neurosci. 16:9950842022.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Wang X, Chen X, Zhou W, Men H, Bao T, Sun
Y, Wang Q, Tan Y, Keller BB, Tong Q, et al: Ferroptosis is
essential for diabetic cardiomyopathy and is prevented by
sulforaphane via AMPK/NRF2 pathways. Acta Pharm Sin B. 12:708–722.
2022. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Huang H, Zhang S, Li Y, Liu Z, Mi L, Cai
Y, Wang X, Chen L, Ran H, Xiao D, et al: Suppression of
mitochondrial ROS by prohibitin drives glioblastoma progression and
therapeutic resistance. Nat Commun. 12:37202021. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Yang X, Wang Z, Samovich SN, Kapralov AA,
Amoscato AA, Tyurin VA, Dar HH, Li Z, Duan S, Kon N, et al:
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct
ferroptotic response during tumor suppression. Cell Metab.
36:762–777.e9. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Chen L, Zhao X, Sheng R, Lazarovici P and
Zheng W: Artemisinin alleviates astrocyte overactivation and
neuroinflammation by modulating the IRE1/NF-κB signaling pathway in
in vitro and in vivo Alzheimer's disease models. Free Radic Biol
Med. 229:96–110. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Sanese P, Fasano C, Buscemi G, Bottino C,
Corbetta S, Fabini E, Silvestri V, Valentini V, Disciglio V, Forte
G, et al: Targeting SMYD3 to sensitize homologous
Recombination-proficient tumors to PARP-Mediated synthetic
lethality. iScience. 23:1016042020. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Chandrashekar DS, Karthikeyan SK, Korla
PK, Patel H, Shovon AR, Athar M, Netto GJ, Qin ZS, Kumar S, Manne
U, et al: UALCAN: An update to the integrated cancer data analysis
platform. Neoplasia. 25:18–27. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Tang Z, Li C, Kang B, Gao G, Li C and
Zhang Z: GEPIA: A web server for cancer and normal gene expression
profiling and interactive analyses. Nucleic Acids Res. 45:W98–W102.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Gyorffy B, Lanczky A, Eklund AC, Denkert
C, Budczies J, Li Q and Szallasi Z: An online survival analysis
tool to rapidly assess the effect of 22,277 genes on breast cancer
prognosis using microarray data of 1,809 patients. Breast Cancer
Res Treat. 123:725–731. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Sabatier R, Finetti P, Adelaide J, Guille
A, Borg JP, Chaffanet M, Lane L, Birnbaum D and Bertucci F:
Down-regulation of ECRG4, a candidate tumor suppressor gene, in
human breast cancer. PLoS One. 6:e276562011. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Zhang W, Sun Y, Bai L, Zhi L, Yang Y, Zhao
Q, Chen C, Qi Y, Gao W, He W, et al: RBMS1 regulates lung cancer
ferroptosis through translational control of SLC7A11. J Clin
Invest. 131:e1520672021. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Wang X, Wang Q, Wang H, Cai G, An Y, Liu
P, Zhou H, Chen HW, Ji S, Ye J, et al: Small protein ERSP encoded
by LINC02870 promotes triple negative breast cancer progression via
IRE1α/XBP1s activation. Cell Death Differ. 32:1014–1025. 2025.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Alanko J, Tanner M, Vanninen R, Auvinen A
and Isola J: Triple-negative and HER2-positive breast cancers found
by mammography screening show excellent prognosis. Breast Cancer
Res Treat. 187:267–274. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Hoeferlin LA, C EC and Park MA: Challenges
in the treatment of triple negative and HER2-Overexpressing breast
cancer. J Surg Sci. 1:3–7. 2013.PubMed/NCBI
|
|
28
|
Park H, Shin DH, Sim JR, Aum S and Lee MG:
IRE1α kinase-mediated unconventional protein secretion rescues
misfolded CFTR and pendrin. Sci Adv. 6:eaax99142020. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Jiang Y and Sun M: SLC7A11: The Achilles
heel of tumor? Front Immunol. 15:14388072024. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Makhov P, Naito S, Haifler M, Kutikov A,
Boumber Y, Uzzo RG and Kolenko VM: The convergent roles of NF-κB
and ER stress in sunitinib-mediated expression of pro-tumorigenic
cytokines and refractory phenotype in renal cell carcinoma. Cell
Death Dis. 9:3742018. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Tang X, Teder T, Samuelsson B and
Haeggstrom JZ: The IRE1α Inhibitor KIRA6 blocks leukotriene
biosynthesis in human phagocytes. Front Pharmacol. 13:8062402022.
View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Gawel S, Wardas M, Niedworok E and Wardas
P: Malondialdehyde (MDA) as a lipid peroxidation marker. Wiad Lek.
57:453–455. 2004.(In Polish). PubMed/NCBI
|
|
33
|
Koppula P, Zhuang L and Gan B: Cystine
transporter SLC7A11/xCT in cancer: Ferroptosis, nutrient
dependency, and cancer therapy. Protein Cell. 12:599–620. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Xu L, Peng F, Luo Q, Ding Y, Yuan F, Zheng
L, He W, Zhang SS, Fu X, Liu J, et al: IRE1α silences dsRNA to
prevent taxane-induced pyroptosis in triple-negative breast cancer.
Cell. 187:7248–7266.e34. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Harnoss JM, Le Thomas A, Shemorry A,
Marsters SA, Lawrence DA, Lu M, Chen YA, Qing J, Totpal K, Kan D,
et al: Disruption of IRE1α through its kinase domain attenuates
multiple myeloma. Proc Natl Acad Sci USA. 116:16420–16429. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Abbasi S, Rivand H, Eshaghi F, Moosavi MA,
Amanpour S, McDermott MF and Rahmati M: Inhibition of IRE1 RNase
activity modulates tumor cell progression and enhances the response
to chemotherapy in colorectal cancer. Med Oncol. 40:2472023.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Cross BC, Bond PJ, Sadowski PG, Jha BK,
Zak J, Goodman JM, Silverman RH, Neubert TA, Baxendale IR, Ron D,
et al: The molecular basis for selective inhibition of
unconventional mRNA splicing by an IRE1-binding small molecule.
Proc Natl Acad Sci USA. 109:E869–E878. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Chan KY, Yu Y, Kong Y, Cheng L, Yao R, Yin
Chair PS, Wang P, Wang R, Sun WY, He RR, et al: GPX4-dependent
ferroptosis sensitivity is a fitness trade-off for cell
enlargement. iScience. 28:1123632025. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Li C, Tan YP, Gao D, Su R, Xu K, Liu SC,
Li XF, Lu YH, Yi LT, Wang G, et al: IRE1alpha RNase activity is
critical for early embryo development by degrading maternal
transcripts. Nucleic Acids Res. 53:gkaf5202025. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Read A and Schroder M: The unfolded
protein response: An overview. Biology (Basel).
10:3842021.PubMed/NCBI
|
|
41
|
Kim P: Understanding the unfolded protein
response (UPR) pathway: Insights into neuropsychiatric disorders
and therapeutic potentials. Biomol Ther (Seoul). 32:183–191. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Saini KK, Chaturvedi P, Sinha A, Singh MP,
Khan MA, Verma A, Nengroo MA, Satrusal SR, Meena S, Singh A, et al:
Loss of PERK function promotes ferroptosis by downregulating
SLC7A11 (System Xc−) in colorectal cancer. Redox Biol.
65:1028332023. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Oka OB, van Lith M, Rudolf J, Tungkum W,
Pringle MA and Bulleid NJ: ERp18 regulates activation of ATF6alpha
during unfolded protein response. EMBO J. 38:e1009902019.
View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Zhao R, Lv Y, Feng T, Zhang R, Ge L, Pan
J, Han B, Song G and Wang L: ATF6α promotes prostate cancer
progression by enhancing PLA2G4A-mediated arachidonic acid
metabolism and protecting tumor cells against ferroptosis.
Prostate. 82:617–629. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Ghosh R, Wang L, Wang ES, Perera BG,
Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, et
al: Allosteric inhibition of the IRE1α RNase preserves cell
viability and function during endoplasmic reticulum stress. Cell.
158:534–548. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Hourihan JM, Moronetti Mazzeo LE,
Fernandez-Cardenas LP and Blackwell TK: Cysteine sulfenylation
directs IRE-1 to activate the SKN-1/Nrf2 antioxidant response. Mol
Cell. 63:553–566. 2016. View Article : Google Scholar : PubMed/NCBI
|
