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Case Report

Gastric cancer in pregnancy: A case report

  • Authors:
    • Jianhua Niu
    • Yan Gao
    • Yu Sun
    • Huixia Yang
  • View Affiliations / Copyright

    Affiliations: Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus, Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, P.R. China, Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus, Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, P.R. China
  • Article Number: 142
    |
    Published online on: February 24, 2026
       https://doi.org/10.3892/ol.2026.15495
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Abstract

Gastric cancer during pregnancy is uncommon but associated with a high maternal mortality rate. Symptoms are often non‑specific, leading to delayed diagnosis due to pregnancy‑related limitations in diagnostic approaches. The present report describes the case of a 35‑year‑old pregnant patient diagnosed with advanced gastric cancer. Although supportive therapies were administered, the condition of the patient deteriorated and they ultimately passed away shortly thereafter. The report highlights how early detection is vital for improving outcomes, underscoring the importance of prompt evaluation of maternal symptoms and targeted diagnostic examinations. Moreover, treatment strategies should be tailored according to the cancer stage and the developmental stage of the fetus. Notably, metastatic sites of gastric cancer during pregnancy can include the placenta, ovaries, lungs, bones and breasts, with fetal metastasis posing a notable clinical concern.

View Figures

Figure 1

Pelvic magnetic resonance imaging and
ultrasonography showing maternal ascites and the intrauterine
fetus. (A) Coronal view and (B) transverse section of pelvic MRI,
with ascites indicated by the red arrow. (C) Abdominal ultrasound,
with ascites indicated by the red arrow. (D) Obstetric ultrasound,
with the fetus indicated by the white arrow.

Figure 2

Abdominal computed tomography,
endoscopy, cytology and histology of gastric signet-ring cell
carcinoma. (A) Coronal view and (B) transverse section of abdominal
CT, with the tumor indicated by the white arrow. (C) Endoscopic
view of the gastric lesion, with the tumor indicated by the white
arrow. (D) Cytological smear of ascitic fluid (magnification,
×400). (E) Microscopic examination of the biopsy (magnification,
×100). (F) Microscopic examination of the biopsy, revealing gastric
primary malignant cells with the signet ring cell indicated by the
red arrow (magnification, ×400).

Figure 3

Timeline of the medical journey of the
patient. GW, gestation week; EGD, esophagogastroduodenoscopy.
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Copy and paste a formatted citation
Spandidos Publications style
Niu J, Gao Y, Sun Y and Yang H: <p>Gastric cancer in pregnancy: A case report</p>. Oncol Lett 31: 142, 2026.
APA
Niu, J., Gao, Y., Sun, Y., & Yang, H. (2026). <p>Gastric cancer in pregnancy: A case report</p>. Oncology Letters, 31, 142. https://doi.org/10.3892/ol.2026.15495
MLA
Niu, J., Gao, Y., Sun, Y., Yang, H."<p>Gastric cancer in pregnancy: A case report</p>". Oncology Letters 31.4 (2026): 142.
Chicago
Niu, J., Gao, Y., Sun, Y., Yang, H."<p>Gastric cancer in pregnancy: A case report</p>". Oncology Letters 31, no. 4 (2026): 142. https://doi.org/10.3892/ol.2026.15495
Copy and paste a formatted citation
x
Spandidos Publications style
Niu J, Gao Y, Sun Y and Yang H: <p>Gastric cancer in pregnancy: A case report</p>. Oncol Lett 31: 142, 2026.
APA
Niu, J., Gao, Y., Sun, Y., & Yang, H. (2026). <p>Gastric cancer in pregnancy: A case report</p>. Oncology Letters, 31, 142. https://doi.org/10.3892/ol.2026.15495
MLA
Niu, J., Gao, Y., Sun, Y., Yang, H."<p>Gastric cancer in pregnancy: A case report</p>". Oncology Letters 31.4 (2026): 142.
Chicago
Niu, J., Gao, Y., Sun, Y., Yang, H."<p>Gastric cancer in pregnancy: A case report</p>". Oncology Letters 31, no. 4 (2026): 142. https://doi.org/10.3892/ol.2026.15495
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