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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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June-2026 Volume 31 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Review Open Access

Hypoxia‑inducible factors: Regulatory functions and status as a therapeutic target in gastric cancer (Review)

  • Authors:
    • Jia Xu
    • Guangzhi Ding
    • Yiming Wang
    • Chang Liu

  • View Affiliations / Copyright

    Affiliations: Gastroenterology Center, Qingdao Traditional Chinese Medicine Hospital, Qingdao Hiser Hospital Affiliated of Qingdao University, Qingdao, Shandong 266000, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 224
    |
    Published online on: April 8, 2026
       https://doi.org/10.3892/ol.2026.15578
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Abstract

Hypoxia, defined as a condition of insufficient tissue oxygenation, is recognized as a key characteristic of solid tumors and is closely associated with their aggressive phenotypic traits. The cellular response to hypoxia is regulated by hypoxia‑inducible factors (HIFs), a family of transcription factors that promote the transcription of gene products involved in driving tumor progression, including processes such as proliferation, angiogenesis, metastasis and drug resistance. In the field of cancer therapeutics, targeting the HIF pathway has emerged as a promising strategy, and the Food and Drug Administration approval in 2021 of Welireg, a novel agent designed to target HIF‑2α for the primary treatment of von Hippel‑Lindau syndrome, has further validated its favorable prospects in tumor therapy. Gastric cancer (GC) continues to pose a notable global health challenge, as it accounts for ~1 million new cases of cancer each year and is responsible for >650,000 mortalities annually. Currently, a range of therapeutic approaches are available for patients diagnosed with GC, yet the 5‑year survival rate remains suboptimal for those with advanced‑stage disease. The present review summarizes the regulatory and target roles of HIFs in GC, thus providing references for GC treatment and emphasizing the potential of HIF‑targeted therapies to disrupt cancer‑associated signaling pathways.

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Copy and paste a formatted citation
Spandidos Publications style
Xu J, Ding G, Wang Y and Liu C: Hypoxia‑inducible factors: Regulatory functions and status as a therapeutic target in gastric cancer (Review). Oncol Lett 31: 224, 2026.
APA
Xu, J., Ding, G., Wang, Y., & Liu, C. (2026). Hypoxia‑inducible factors: Regulatory functions and status as a therapeutic target in gastric cancer (Review). Oncology Letters, 31, 224. https://doi.org/10.3892/ol.2026.15578
MLA
Xu, J., Ding, G., Wang, Y., Liu, C."Hypoxia‑inducible factors: Regulatory functions and status as a therapeutic target in gastric cancer (Review)". Oncology Letters 31.6 (2026): 224.
Chicago
Xu, J., Ding, G., Wang, Y., Liu, C."Hypoxia‑inducible factors: Regulatory functions and status as a therapeutic target in gastric cancer (Review)". Oncology Letters 31, no. 6 (2026): 224. https://doi.org/10.3892/ol.2026.15578
Copy and paste a formatted citation
x
Spandidos Publications style
Xu J, Ding G, Wang Y and Liu C: Hypoxia‑inducible factors: Regulatory functions and status as a therapeutic target in gastric cancer (Review). Oncol Lett 31: 224, 2026.
APA
Xu, J., Ding, G., Wang, Y., & Liu, C. (2026). Hypoxia‑inducible factors: Regulatory functions and status as a therapeutic target in gastric cancer (Review). Oncology Letters, 31, 224. https://doi.org/10.3892/ol.2026.15578
MLA
Xu, J., Ding, G., Wang, Y., Liu, C."Hypoxia‑inducible factors: Regulatory functions and status as a therapeutic target in gastric cancer (Review)". Oncology Letters 31.6 (2026): 224.
Chicago
Xu, J., Ding, G., Wang, Y., Liu, C."Hypoxia‑inducible factors: Regulatory functions and status as a therapeutic target in gastric cancer (Review)". Oncology Letters 31, no. 6 (2026): 224. https://doi.org/10.3892/ol.2026.15578
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