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![Machine learning-based prognostic
model in LUAD. (A) Heatmap of mean C-index values for 101 model
combinations across TCGA, GSE31210 and GSE72094; the StepCox
[forward]+Ridge model is highlighted. Kaplan-Meier curves for
high-vs. low-risk groups in (B) TCGA, (C) GSE31210 and (D)
GSE72094; HR, 95% CI and P-value shown). (E) Time-dependent ROC
curves at 1, 3 and 5 years for the selected model in all three
cohorts. LUAD, lung adenocarcinoma; TCGA, The Cancer Genome Atlas;
HR, hazard ratio; ROC, receiver operating characteristic; CI,
confidence interval.](/article_images/ol/32/3/ol-32-03-15774-g02.jpg)
