Clinicopathological study of hepatocellular carcinoma with peliotic change

Fujimoto,Masaru; Nakashima,Osamu; Komuta,Mina; Miyaaki,Toshimitsu; Kojiro,Masamichi; Yano,Hirohisa

doi:10.3892/ol_00000003

January-February 2010 Volume 1 Issue 1

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

January-February 2010 Volume 1 Issue 1

Full Size Image

Article

Clinicopathological study of hepatocellular carcinoma with peliotic change

Authors:
- Masaru Fujimoto
- Osamu Nakashima
- Mina Komuta
- Toshimitsu Miyaaki
- Masamichi Kojiro
- Hirohisa Yano
View Affiliations / Copyright

Affiliations: Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan
Pages: 17-21
|
Published online on: January 1, 2010

https://doi.org/10.3892/ol_00000003
Expand metrics +

Abstract

Peliosis hepatis-like blood-filled cavities are frequently observed in the tumors of hepatocellular carcinoma (HCC). This finding is generally referred to as ‘peliotic change’ in HCC. However, the clinicopathological features of HCC with peliotic change (PHCC) are not fully understood. These issues are addressed in the present study. Among 294 consecutively surgically resected HCCs, the clinicopathological features of PHCC were compared with those of a common type of HCC (control). PHCC was observed in 116 (39.5%) of 294 HCCs. The mean tumor diameter of 3.4±0.9 cm of the PHCC group was significantly larger than that of the 2.5±0.9 cm of the control, and the incidence of PHCC was related to increased tumor diameter. In the 116 PHCCs, the tumors were completely or incompletely encapsulated. On ultrasonography, PHCCs showed hyperechoic and/or mosaic patterns. The mean diameter of 3.5±0.8 cm of PHCCs with a hyperechoic and/or mosaic pattern was significantly larger than that of 2.3±0.9 cm in the control. In conclusion, it is necessary for clinicians and pathologists to discern the characteristics of peliotic change as a morphological feature that modifies ultrasound findings.

View Figures

View References

1	Karasawa T, Shikata T and Roger DS: Peliosis hepatis: report of nine cases. Acta Pathol Jpn. 29:457–469. 1979.PubMed/NCBI
2	Zafrani ES, Cazier A, Baudelot AM and Feldmann G: Ultrastructural lesions of the liver in human peliosis. A report of 12 cases. Am J Pathol. 114:349–359. 1984.PubMed/NCBI
3	Asano S, Wakasa H, Kaise S, Nishimaki T and Kasukawa R: Peliosis hepatis: Report of two autopsy cases with a review of literature. Acta Pathol Jpn. 32:861–877. 1982.PubMed/NCBI
4	Wagner E: Fall von Blutcysten der Leber (In German). Arch Heilk. 2:369–370. 1861.
5	Kojiro M: Peliosis hepatis (In Japanese). Acta Hepatol Jpn (KANZO). 38:583–586. 1997. View Article : Google Scholar
6	Grazioli L, Morana G, Caudana R, et al: Hepatocellular carcinoma: correlation between gadobenate dimeglumine-enhanced MRI and pathological findings. Invest Radiol. 35:25–34. 2000. View Article : Google Scholar
7	Brancatelli G, Baron RL, Peterson MS and Marsh W: Helical CT screening for hepatocellular carcinoma in patient with cirrhosis: frequency and cases of false-positive interpretation. Am J Roentgenol. 180:1007–1014. 2003. View Article : Google Scholar : PubMed/NCBI
8	Loomus GN, Aneja P and Bota RA: A case of peliosis hepatis in association with tamoxifen therapy. Am J Clin Pathol. 80:881–882. 1983.PubMed/NCBI
9	Dejgaard A, Krogsgaard K and Jacobsen M: Veno-occlusive disease and peliosis of the liver after thorotrast administration. Virchows Arch A Pathol Anat Histopathol. 403:87–94. 1984. View Article : Google Scholar : PubMed/NCBI
10	Czapar CA, Weldon-Linne CM, Moore DM and Rhone DP: Peliosis hepatis in the acquired immunodeficiency syndrome. Arch Pathol Lab Med. 110:611–613. 1986.PubMed/NCBI
11	Russmann S, Zimmermann A, Krahenbuhl S, Kern B and Reichen J: Veno-occlusive disease, nodular regenerative hyperplasia and hepatocellular carcinoma after azathioprine treatment in a patient with uncreative colitis. Eur J Gastroenterol Hepatol. 13:287–290. 2001. View Article : Google Scholar
12	Drevelengas A, Chourmouzi D and Boulogianni G: Peliosis of the liver in a patient with prostate carcinoma. JBR-BTR. 86:158–159. 2003.PubMed/NCBI
13	Shim SG, Paik SW, Hyun JG, et al: Lipiodol accumulation in focal peliosis hepatis with sinusoidal dilatation. J Clin Gastroenterol. 32:356–358. 2001. View Article : Google Scholar : PubMed/NCBI
14	Sugimachi K, Tanaka S, Taguchi K, Aishima S, Shimada M and Tsuneyoshi M: Angiopoietin switching regulates angiogenesis and progression of human hepatocellular carcinoma. J Clin Pathol. 56:854–860. 2003. View Article : Google Scholar : PubMed/NCBI
15	Kutami R, Nakashima Y, Nakashima O, Shiota K and Kojiro M: Pathomorphologic study on the mechanism of fatty change in small hepatocellular carcinoma of humans. J Hepatol. 33:282–289. 2000. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinicopathological study of hepatocellular carcinoma with peliotic change

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Related Articles