In vivo anti-tumor activity of photodynamic therapy with intravenous administration of acridine orange, followed by illumination with high-power flash wave light in a mouse osteosarcoma model

Dougherty TJ and Marcus SL: Photodynamic therapy. Eur J Cancer. 28A:1734–1742. 1992. View Article : Google Scholar : PubMed/NCBI

Moan J and Berg K: Photochemotherapy of cancer: experimental research. Photochem Photobiol. 55:931–948. 1992. View Article : Google Scholar

Kusuzaki K, Murata H, Matsubara T, et al: Clinical trial of photodynamic therapy using acridine orange with/without low dose radiation as new limb salvage modality in musculoskeletal sarcomas. Anticancer Res. 25:1225–1236. 2005.PubMed/NCBI

Kusuzaki K, Murata H, Matsubara T, et al: Clinical outcome of a novel photodynamic therapy technique using acridine orange for synovial sarcomas. Photochem Photobiol. 81:705–709. 2005. View Article : Google Scholar : PubMed/NCBI

Yoshida K, Kusuzaki K, Matsubara T, et al: Periosteal Ewing’s sarcoma treated by photodynamic therapy with acridine orange. Oncol Rep. 13:279–282. 2005.

Kusuzaki K, Murata H, Matsubara T, Satonaka H, Wakabayashi T, Matsumine A and Uchida A: Acridine orange could be an innovative anticancer agent under photon energy (Review). In Vivo. 21:205–214. 2007.PubMed/NCBI

Nakamura T, Kusuzaki K, Matsubara T, Matsumine A, Murata H and Uchida A: A new limb salvage surgery in cases of high-grade soft tissue sarcoma using photodynamic surgery, followed by photo- and radiodynamic therapy with acridine orange. J Surg Oncol. 97:523–528. 2008. View Article : Google Scholar

Ueda H, Murata H, Takeshita H, Minami G, Hashiguchi S and Kubo T: Unfiltered xenon light is useful for photodynamic therapy with acridine orange. Anticancer Res. 25:3979–3984. 2005.PubMed/NCBI

Satonaka H, Kusuzaki K, Matsubara T, et al: Flash wave light strongly enhanced the cytocidal effect of photodynamic therapy with acridine orange on a mouse osteosarcoma cell line. Anticancer Res. 27:3339–3344. 2007.PubMed/NCBI

Satonaka H, Kusuzaki K, Matsubara T, Shintani K, Wakabayashi T, Matsumine A and Uchida A: Extracorporeal photodynamic image detection of mouse osteosarcoma in soft tissues utilizing fluorovisualization effect of acridine orange. Oncology. 70:465–473. 2006. View Article : Google Scholar

Asai T, Ueda T, Itoh K, Yoshioka K, Aoki Y, Mori S and Yoshikawa H: Establishment and characterization of a murine osteosarcoma cell line (LM8) with high metastatic potential to the lung. Int J Cancer. 76:418–422. 1998. View Article : Google Scholar : PubMed/NCBI

Kimura M, Kashikura K, Yokoi S, Koiwa Y, Tokuoka Y and Kawashima N: Photodynamic therapy for cancer cells using a flash wave light xenon lamp. Opt Rev. 12:207–210. 2005. View Article : Google Scholar

Ovejera AA, Houchens DP and Barker AD: Chemotherapy of human tumor xenografts in genetically athymic mice. Ann Clin Lab Sci. 8:50–56. 1978.PubMed/NCBI

Kusuzaki K, Suginoshita T, Minami G, et al: Fluorovisualization effect of acridine orange on mouse osteosarcoma. Anticancer Res. 20:3019–3024. 2000.PubMed/NCBI

Kusuzaki K, Minami G, Takeshita H, et al: Photodynamic inactivation with acridine orange on a multidrug-resistant mouse osteosarcoma cell line. Jpn J Cancer Res. 91:439–445. 2000. View Article : Google Scholar : PubMed/NCBI

Matsubara T, Kusuzaki K, Matsumine A, Shintani K, Satonaka H and Uchida A: Acridine orange used for photodynamic therapy accumulates in malignant musculoskeletal tumors depending on pH gradient. Anticancer Res. 26:187–194. 2006.PubMed/NCBI

Kusuzaki K, Murata H, Takeshita H, et al: Intracellular binding sites of acridine orange in living osteosarcoma cells. Anticancer Res. 20:971–976. 2000.PubMed/NCBI

Kusuzaki K, Aomori K, Suginoshita T, et al: Total tumor cell elimination with minimum damage to normal tissues in musculoskeletal sarcomas following photodynamic therapy with acridine orange. Oncology. 59:174–180. 2000. View Article : Google Scholar

Hashiguchi S, Kusuzaki K, Murata H, et al: Acridine orange excited by low-dose radiation has a strong cytocidal effect on mouse osteosarcoma. Oncology. 65:85–93. 2005.PubMed/NCBI

Kessel D and Luo Y: Mitochondrial photodamage and PDT-induced apoptosis. Photochem Photobiol. 42:89–85. 1998. View Article : Google Scholar : PubMed/NCBI

Zdolsek JM, Olson M and Brunk UT: Photooxidative damage to lysosomes of cultured macrophages by acridine orange. Photochem Photobiol. 51:67–76. 1990. View Article : Google Scholar : PubMed/NCBI