Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-February 2010 Volume 1 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-February 2010 Volume 1 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Diagnostic value of 18F-fluorodeoxyglucose positron emission tomography for pancreatic neuroendocrine tumors with reference to the World Health Organization classification

  • Authors:
    • Toshihiko Masui
    • Ryuichiro Doi
    • Tatsuo Ito
    • Kazuhiro Kami
    • Kohei Ogawa
    • Daisuke Harada
    • Shinji Uemoto
  • View Affiliations / Copyright

    Affiliations: Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Kyoto University, 606-8507 Kyoto, Japan
  • Pages: 155-159
    |
    Published online on: January 1, 2010
       https://doi.org/10.3892/ol_00000029
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The 2004 classification of the World Health Organization (WHO) has demonstrated an efficacy for prediction of the prognosis of pancreatic neuroendocrine tumors. This study aimed to assess the predictive value of preoperative 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in relation to the 2004 WHO criteria. The histology of 21 pancreatic endocrine tumors resected at our hospital was reviewed and the tumors were classified according to the 2004 WHO criteria. FDG-PET findings were analyzed by comparing the findings with CT scans. FDG uptake was positive in 10 primary endocrine tumors (47%), but no uptake was seen in 11 tumors. In relation to the 2004 WHO classification, 1 out of 8 well-differentiated tumors with benign behavior was positive by PET (12.5%), 4 out of 7 well-differentiated tumors with uncertain behavior were positive (57%) and 4 low-grade malignant tumors were positive (100%). According to the WHO criteria, the rate of positive FDG uptake increased as the malignant potential increased. The metastases of low-grade malignant tumors also showed a positive FDG uptake. In conclusion, from our limited experience, FDG-PET appears to be useful for identifying pancreatic neuroendocrine tumors with a higher malignant potential. In addition, FDG-PET can detect distant metastases and may contribute to better staging of advanced disease.
View Figures

Figure 1

View References

1 

Rha SE, Jung SE, Lee KH, Ku YM, Byun JY and Lee JM: CT and MR imaging findings of endocrine tumor of the pancreas according to WHO classification. Eur J Radiol. 62:371–377. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Modlin IM and Sandor A: An analysis of 8305 cases of carcinoid tumors. Cancer. 79:813–829. 1997. View Article : Google Scholar : PubMed/NCBI

3 

Phan GQ, Yeo CJ, Hruban RH, Lillemoe KD, Pitt HA and Cameron JL: Surgical experience with pancreatic and peripancreatic neuroendocrine tumors: review of 125 patients. J Gastrointest Surg. 2:472–482. 1998.

4 

Hochwald SN, Zee S, Conlon KC, Colleoni R, Louie O, Brennan MF and Klimstra DS: Prognostic factors in pancreatic endocrine neoplasms: an analysis of 136 cases with a proposal for low-grade and intermediate-grade groups. J Clin Oncol. 20:2633–2642. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Heitz PU, Komminoth P, Perren A, Klimstra DS, Dayal Y, Bordi C, Lechagon J, Centeno BA and Kloppel G: Tumours of the endocrine pancreas. Pathology and Genetics of Tumours of Endocrine Organs (World Health Organization Classification of Tumours). DeLellis RA, Lloyd RV, Heitz PU and Eng C: IARC Press; Lyon: pp. 177–182. 2004

6 

Capella C, Heitz PU, Hofler H, Solcia E and Kloppel G: Revised classification of neuroendocrine tumors of the lung, pancreas and gut. Digestion. 55:11–23. 1994. View Article : Google Scholar : PubMed/NCBI

7 

Bettini R, Boninsegna L, Mantovani W, Capelli P, Bassi C, Pederzoli P, Delle Fave GF, Panzuto F, Scarpa A and Falconi M: Prognostic factors at diagnosis and value of WHO classification in a mono-institutional series of 180 non-functioning pancreatic endocrine tumours. Ann Oncol. 19:903–908. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Schmitt AM, Anlauf M, Rousson V, Schmid S, Kofler A, Riniker F, Bauersfeld J, Barghorn A, Probst-Hensch NM, Moch H, Heitz PU, Kloeppel G, Komminoth P and Perren A: WHO 2004 criteria and CK19 are reliable prognostic markers in pancreatic endocrine tumors. Am J Surg Pathol. 31:1677–1682. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Ferrone CR, Tang LH, Tomlinson J, Gonen M, Hochwald SN, Brennan MF, Klimstra DS and Allen PJ: Determining prognosis in patients with pancreatic endocrine neoplasms: can the WHO classification system be simplified? J Clin Oncol. 25:5609–5615. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Reske SN and Kotzerke J: FDG-PET for clinical use. Results of the 3rd German Interdisciplinary Consensus Conference, ‘Onko-PET III’, 21 July and 19 September 2000. Eur J Nucl Med. 28:1707–1723. 2001.

11 

Bombardieri E, Aktolun C, Baum RP, Bishof-Delaloye A, Buscombe J, Chatal JF, Maffioli L, Moncayo R, Mortelmans L and Reske SN: FDG-PET: procedure guidelines for tumour imaging. Eur J Nucl Med Mol Imaging. 30:BP115–124. 2003.PubMed/NCBI

12 

Adams S, Baum R, Rink T, Schumm-Drager PM, Usadel KH and Hor G: Limited value of fluorine-18 fluorodeoxyglucose positron emission tomography for the imaging of neuroendocrine tumours. Eur J Nucl Med. 25:79–83. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Pasquali C, Rubello D, Sperti C, Gasparoni P, Liessi G, Chierichetti F, Ferlin G and Pedrazzoli S: Neuroendocrine tumor imaging: can 18F-fluorodeoxyglucose positron emission tomography detect tumors with poor prognosis and aggressive behavior? World J Surg. 22:588–592. 1998. View Article : Google Scholar

14 

Eriksson B, Bergstrom M, Orlefors H, Sundin A, Oberg K and Langstrom B: Use of PET in neuroendocrine tumors. In vivo applications and in vitro studies. Q J Nucl Med. 44:68–76. 2000.PubMed/NCBI

15 

Eriksson B, Bergstrom M, Sundin A, Juhlin C, Orlefors H, Oberg K and Langstrom B: The role of PET in localization of neuroendocrine and adrenocortical tumors. Ann NY Acad Sci. 970:159–169. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Pawlikowski M and Melen-Mucha G: Somatostatin analogs from new molecules to new applications. Curr Opin Pharmacol. 4:608–613. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Pacak K, Eisenhofer G and Goldstein DS: Functional imaging of endocrine tumors: role of positron emission tomography. Endocr Rev. 25:568–580. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Sperti C, Pasquali C, Chierichetti F, Ferronato A, Decet G and Pedrazzoli S: 18-Fluorodeoxyglucose positron emission tomography in predicting survival of patients with pancreatic carcinoma. J Gastrointest Surg. 7:953–959. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Vansteenkiste JF, Stroobants SG, Dupont PJ, De Leyn PR, Verbeken EK, Deneffe GJ, Mortelmans LA and Demedts MG: Prognostic importance of the standardized uptake value on (18)F-fluoro-2-deoxy-glucose-positron emission tomography scan in non-small-cell lung cancer: An analysis of 125 cases. Leuven Lung Cancer Group. J Clin Oncol. 17:3201–3206. 1999.

20 

Downey RJ, Akhurst T, Gonen M, Vincent A, Bains MS, Larson S and Rusch V: Preoperative F-18 fluorodeoxyglucose-positron emission tomography maximal standardized uptake value predicts survival after lung cancer resection. J Clin Oncol. 22:3255–3260. 2004. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Masui T, Doi R, Ito T, Kami K, Ogawa K, Harada D and Uemoto S: Diagnostic value of 18F-fluorodeoxyglucose positron emission tomography for pancreatic neuroendocrine tumors with reference to the World Health Organization classification . Oncol Lett 1: 155-159, 2010.
APA
Masui, T., Doi, R., Ito, T., Kami, K., Ogawa, K., Harada, D., & Uemoto, S. (2010). Diagnostic value of 18F-fluorodeoxyglucose positron emission tomography for pancreatic neuroendocrine tumors with reference to the World Health Organization classification . Oncology Letters, 1, 155-159. https://doi.org/10.3892/ol_00000029
MLA
Masui, T., Doi, R., Ito, T., Kami, K., Ogawa, K., Harada, D., Uemoto, S."Diagnostic value of 18F-fluorodeoxyglucose positron emission tomography for pancreatic neuroendocrine tumors with reference to the World Health Organization classification ". Oncology Letters 1.1 (2010): 155-159.
Chicago
Masui, T., Doi, R., Ito, T., Kami, K., Ogawa, K., Harada, D., Uemoto, S."Diagnostic value of 18F-fluorodeoxyglucose positron emission tomography for pancreatic neuroendocrine tumors with reference to the World Health Organization classification ". Oncology Letters 1, no. 1 (2010): 155-159. https://doi.org/10.3892/ol_00000029
Copy and paste a formatted citation
x
Spandidos Publications style
Masui T, Doi R, Ito T, Kami K, Ogawa K, Harada D and Uemoto S: Diagnostic value of 18F-fluorodeoxyglucose positron emission tomography for pancreatic neuroendocrine tumors with reference to the World Health Organization classification . Oncol Lett 1: 155-159, 2010.
APA
Masui, T., Doi, R., Ito, T., Kami, K., Ogawa, K., Harada, D., & Uemoto, S. (2010). Diagnostic value of 18F-fluorodeoxyglucose positron emission tomography for pancreatic neuroendocrine tumors with reference to the World Health Organization classification . Oncology Letters, 1, 155-159. https://doi.org/10.3892/ol_00000029
MLA
Masui, T., Doi, R., Ito, T., Kami, K., Ogawa, K., Harada, D., Uemoto, S."Diagnostic value of 18F-fluorodeoxyglucose positron emission tomography for pancreatic neuroendocrine tumors with reference to the World Health Organization classification ". Oncology Letters 1.1 (2010): 155-159.
Chicago
Masui, T., Doi, R., Ito, T., Kami, K., Ogawa, K., Harada, D., Uemoto, S."Diagnostic value of 18F-fluorodeoxyglucose positron emission tomography for pancreatic neuroendocrine tumors with reference to the World Health Organization classification ". Oncology Letters 1, no. 1 (2010): 155-159. https://doi.org/10.3892/ol_00000029
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team