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Article

Erlotinib treatment in pretreated patients with non-small cell lung cancer: A Phase II study

  • Authors:
    • G. P. Stathopoulos
    • D. Trafalis
    • J. Dimitroulis
    • A. Athanasiou
    • J. Koutantos
    • A. Anagnostopoulos
  • View Affiliations / Copyright

    Affiliations: First Oncology Clinic, Errikos Dunant Hospital, Athens, Greece
  • Pages: 335-338
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/ol_00000059
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Abstract

Erlotinib is an oral, small-molecule targeting therapy that inhibits epidermal growth factor tyrosine kinase receptors. Erlotinib has been administered for the treatment of advanced pancreatic cancer and non-small cell lung cancer. In the present trial, erlotinib was administered as second-line monotherapy in pretreated patients with advanced non-small cell lung cancer. Our objectives were to determine response, survival and toxicity. Fifty-four patients pretreated with cisplatin or its analogue-based combinations were evaluated. The disease stage of the patients was IIIB and IV. Thirty-eight patients were male, 16 were female, the median age was 65 years, and the WHO performance status was 0-2. Twenty-five cases were adenocarcinomas, 19 squamous cell carcinomas and 10 were undifferentiated. Erlotinib was administered at a dose of 150 mg daily. In case of intolerable adverse reactions, the dose was either reduced to 100 mg daily or treatment was interrupted for a maximum of two weeks. A partial response was observed in 10 (18.52%) and stable disease in 40 (74.07%) patients. The median time to disease progression was 3 months (95% CI 1.7-10.3), and the median survival was 6 months. Concerning toxicity, 53 patients (98.15%) developed a grade 1-2 skin rash, and 1 (1.85%) grade 3. Diarrhea occurred in 9 (16.67%) patients, nausea and vomiting in 4 (7.41%) and gastritis in 2 (3.70%). The majority of patients tolerated the erlotinib treatment. Of note were the 18.52% response rate and 74.07% stable disease.
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Copy and paste a formatted citation
Spandidos Publications style
Stathopoulos GP, Trafalis D, Dimitroulis J, Athanasiou A, Koutantos J and Anagnostopoulos A: Erlotinib treatment in pretreated patients with non-small cell lung cancer: A Phase II study . Oncol Lett 1: 335-338, 2010.
APA
Stathopoulos, G.P., Trafalis, D., Dimitroulis, J., Athanasiou, A., Koutantos, J., & Anagnostopoulos, A. (2010). Erlotinib treatment in pretreated patients with non-small cell lung cancer: A Phase II study . Oncology Letters, 1, 335-338. https://doi.org/10.3892/ol_00000059
MLA
Stathopoulos, G. P., Trafalis, D., Dimitroulis, J., Athanasiou, A., Koutantos, J., Anagnostopoulos, A."Erlotinib treatment in pretreated patients with non-small cell lung cancer: A Phase II study ". Oncology Letters 1.2 (2010): 335-338.
Chicago
Stathopoulos, G. P., Trafalis, D., Dimitroulis, J., Athanasiou, A., Koutantos, J., Anagnostopoulos, A."Erlotinib treatment in pretreated patients with non-small cell lung cancer: A Phase II study ". Oncology Letters 1, no. 2 (2010): 335-338. https://doi.org/10.3892/ol_00000059
Copy and paste a formatted citation
x
Spandidos Publications style
Stathopoulos GP, Trafalis D, Dimitroulis J, Athanasiou A, Koutantos J and Anagnostopoulos A: Erlotinib treatment in pretreated patients with non-small cell lung cancer: A Phase II study . Oncol Lett 1: 335-338, 2010.
APA
Stathopoulos, G.P., Trafalis, D., Dimitroulis, J., Athanasiou, A., Koutantos, J., & Anagnostopoulos, A. (2010). Erlotinib treatment in pretreated patients with non-small cell lung cancer: A Phase II study . Oncology Letters, 1, 335-338. https://doi.org/10.3892/ol_00000059
MLA
Stathopoulos, G. P., Trafalis, D., Dimitroulis, J., Athanasiou, A., Koutantos, J., Anagnostopoulos, A."Erlotinib treatment in pretreated patients with non-small cell lung cancer: A Phase II study ". Oncology Letters 1.2 (2010): 335-338.
Chicago
Stathopoulos, G. P., Trafalis, D., Dimitroulis, J., Athanasiou, A., Koutantos, J., Anagnostopoulos, A."Erlotinib treatment in pretreated patients with non-small cell lung cancer: A Phase II study ". Oncology Letters 1, no. 2 (2010): 335-338. https://doi.org/10.3892/ol_00000059
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