The human pluripotency gene NANOG/NANOGP8 is expressed in gastric cancer and associated with tumor development

Zhang,Jingyu; Wang,Xia; Chen,Bing; Xiao,Zhifeng; Li,Wenmei; Lu,Youyong; Dai,Jianwu

doi:10.3892/ol_00000081

The human pluripotency gene NANOG/NANOGP8 is expressed in gastric cancer and associated with tumor development

Authors:
- Jingyu Zhang
- Xia Wang
- Bing Chen
- Zhifeng Xiao
- Wenmei Li
- Youyong Lu
- Jianwu Dai
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Affiliations: Laboratory of Molecular Oncology, Key Laboratory of Carcinogenesis and Translational Research, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing 100142, P.R. China
Published online on: May 1, 2010 https://doi.org/10.3892/ol_00000081
Pages: 457-463

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Abstract

It is well known that cancer cells exhibit characteristics similar to normal stem cells. The majority of tumors frequently overexpress genes commonly found in embryonic stem cells. To determine whether the pluripotency gene NANOG and its retrogene, NANOGP8, play a role in gastric cancer, we analyzed the NANOG/NANOGP8 expression profile at the mRNA and protein level in primary gastric tumors. Our data demonstrated that overexpression of NANOG/NANOGP8 was consistently detected in primary tumors (75%, 30/40) compared to adjacent normal tissues (12.5%, 5/40). Furthermore, NANOG/NANOGP8 was highly expressed in the intestinal metaplasia (60%, 24/40) and dysplasia tissues (66.7%, 20/30) compared to normal tissues. These results suggest that NANOG/NANOGP8 exhibits potential as a biomarker and its expression may play an important role in gastric cancer development.

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