Evaluation of contrast-enhanced ultrasonography using perfluorobutane (Sonazoid®) in patients with small hepatocellular carcinoma: Comparison with dynamic computed tomography

Kan,Miki; Hiraoka,Atsushi; Uehara,Takahide; Hidaka,Satoshi; Ichiryu,Misa; Nakahara,Hiromasa; Ochi,Hironori; Tanabe,Atsushi; Kodama,Akihiro; Hasebe,Aki; Miyamoto,Yasuyuki; Ninomiya,Tomoyuki; Abe,Masanori; Hiasa,Yoichi; Matsuura,Bunzo; Onji,Morikazu; Shinbata,Yuki; Kameoka,Chieko; Doi,Shigekazu; Tamura,Hiromi; Furuya,Keizou; Michitaka,Kojiro

doi:10.3892/ol_00000085

May-June 2010 Volume 1 Issue 3

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

May-June 2010 Volume 1 Issue 3

Full Size Image

Article

Evaluation of contrast-enhanced ultrasonography using perfluorobutane (Sonazoid®) in patients with small hepatocellular carcinoma: Comparison with dynamic computed tomography

Authors:
- Miki Kan
- Atsushi Hiraoka
- Takahide Uehara
- Satoshi Hidaka
- Misa Ichiryu
- Hiromasa Nakahara
- Hironori Ochi
- Atsushi Tanabe
- Akihiro Kodama
- Aki Hasebe
- Yasuyuki Miyamoto
- Tomoyuki Ninomiya
- Masanori Abe
- Yoichi Hiasa
- Bunzo Matsuura
- Morikazu Onji
- Yuki Shinbata
- Chieko Kameoka
- Shigekazu Doi
- Hiromi Tamura
- Keizou Furuya
- Kojiro Michitaka
View Affiliations / Copyright

Affiliations: Department of Medical Laboratory, Ehime Prefectural Central Hospital, Ehime 790-0024, Japan
Pages: 485-488
|
Published online on: May 1, 2010

https://doi.org/10.3892/ol_00000085
Expand metrics +

Abstract

This study aimed to elucidate the efficacy of contrast-enhanced ultrasonography (CEUS) with perfluorobutane (Sonazoid®) in the diagnosis of hepatocellular carcinomas (HCCs), particularly small HCCs, by comparing the results with dynamic computed tomography (Dy-CT). Seventy-nine nodules in 69 patients with chronic liver disease, suspected as HCCs were studied. The nodules were selected based on the results of B-mode ultrasonography and/or Dy-CT conducted between January and August 2007. The nodules were divided into two groups: the S-group with tumors ≤2 cm (49 nodules), and the L-group with tumors >2 cm (30 nodules). Typical HCCs were defined, and the nodules were enhanced and shown as defects in the arterial and late phase of Dy-CT, respectively. Target lesions were scanned using CEUS, and the results were compared with those of Dy-CT. The L-group nodules diagnosed as HCCs using Dy-CT were also diagnosed as HCCs using CEUS. In the S-group, the diagnostic sensitivity of CEUS was 94.7% and the specificity was 81.8%. We diagnosed two liver tumors that were detected by CEUS but not by Dy-CT; biopsies revealed one tumor to be a well-differentiated HCC and the other to be an atypical adenomatous hyperplasia. The sensitivity and specificity of CEUS against HCC were high even in the small-size HCCs. Thus, Sonazoid is useful in the screening for small HCCs.

View Figures

View References

1	Sontum PC: Physiochemical characteristics of Sonazoid, a new contrast agent for ultrasound imaging. Ultrasound Med Biol. 34:824–833. 2008. View Article : Google Scholar : PubMed/NCBI
2	Watanabe R, Matsumura M, Chen CJ, et al: Characterization of tumor imaging with microbubble-based ultrasound contrast agent, sonazoid, in rabbit liver. Biol Pharm Bull. 28:972–977. 2005. View Article : Google Scholar : PubMed/NCBI
3	Bruix J and Sherman M: Management of hepatocellular carcinoma. Hepatology. 42:1208–1236. 2005. View Article : Google Scholar
4	Watanabe R, Matsumura M, Munrmasa T, et al: Mechanism of hepatic parenchyma-specific contrast of microbubble-based contrast agent for ultrasonography: microscopic studies in rat liver. Invest Radiol. 42:643–651. 2007. View Article : Google Scholar
5	Kindberg GM, Tolleshaug H, Roos N, et al: Hepatic clearance of Sonazoid perfluorobutane microbubbles by Kupffer cells does not reduce the ability of liver to phagocytose or degrade albumin microspheres. Cell Tissue Res. 312:49–54. 2003.
6	Kudo M: New sonographic techniques for the diagnosis and treatment of hepatocellular carcinoma. Hepatol Res. 37(Suppl 2): 193–199. 2007. View Article : Google Scholar
7	Nakashima O, Sugihara S, Kage M, et al: Pathomorphologic characteristics of small hepatocellular carcinoma: a special reference to small hepatocellular carcinoma with indistinct margins. Hepatology. 22:101–105. 1995.
8	Matsui O, Kadoya M, Kameyama T, et al: Benign and malignant nodules in cirrhotic livers: distinction based on blood supply. Radiology. 178:493–497. 1991. View Article : Google Scholar : PubMed/NCBI
9	Wang JH, Lu SN, Hung CH, et al: Small hepatic nodules (< or =2 cm) in cirrhosis patients: characterization with contrast-enhanced ultrasonography. Liver Int. 26:928–934. 2006.
10	Numata K, Morimoto M, Ogura M, et al: Ablation therapy guided by contrast-enhanced sonography with Sonazoid for hepatocellular carcinoma lesions not detected by conventional sonography. Ultrasound Med. 27:395–406. 2008.PubMed/NCBI
11	Minami Y, Chung H, Kudo M, et al: Radiofrequency ablation of hepatocellular carcinoma: value of virtual CT sonography with magnetic navigation. Am J Roentgenol. 190:W335–W341. 2008. View Article : Google Scholar : PubMed/NCBI
12	Hohmann J, Skrok J, Puls R, et al: Characterization of focal liver lesions with contrast-enhanced low MI real time ultrasound and SonoVue. Rofo. 175:835–843. 2003.PubMed/NCBI
13	Giorgio A, De Stefano G, Coppola C, et al: Contrast-enhanced sonography in the characterization of small hepatocellular carcinomas in cirrhotic patients: comparison with contrast-enhanced ultrafast magnetic resonance imaging. Anticancer Res. 27:4263–4269. 2007.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Evaluation of contrast-enhanced ultrasonography using perfluorobutane (Sonazoid®) in patients with small hepatocellular carcinoma: Comparison with dynamic computed tomography

This article is mentioned in:

Abstract

Figure 1

Figure 2

Related Articles